Nxera’s Partner Cancer Research UK to Present on Phase 1/2a Clinical Trial with Cancer Immunotherapy Drug HTL0039732 at ESMO
September 13 2024 - 2:30AM
- HTL0039732 (also known as NXE0039732) is Nxera’s novel oral EP4
antagonist with the potential to treat a wide range of cancers in
combination with other immunotherapies
- Cancer Research UK’s Centre for Drug Development is sponsoring
and managing the ongoing Phase 1/2a clinical trial of
HTL0039732
Tokyo, Japan and Cambridge and London,
UK, 13 September 2024 –
Nxera Pharma (TSE: 4565, “Nxera”) and Cancer Research UK announce
an upcoming presentation on the ongoing Phase 1/2a clinical trial
(NCT05944237) of Nxera’s immunotherapy drug HTL0039732 (also known
as NXE0039732) at the European Society for Medical Oncology
Congress (ESMO) 2024, taking place on 13–17 September in Barcelona,
Spain.
The trial’s co-chief investigator, Dr. Debashis
Sarker from Guy's and St Thomas’ NHS Foundation Trust, will present
a “Trial in Progress1” poster at ESMO 2024 on Saturday 14 September
(presentation 679TiP, available on the ESMO website here).
The first-in-human trial is evaluating the
safety, tolerability, pharmacokinetics, pharmacodynamics and
anti-tumor activity of HTL0039732 as a monotherapy and in
combination with the checkpoint inhibitor atezolizumab, in patients
with advanced solid tumors.
HTL0039732 is an oral small molecule drug
candidate that was rationally designed using Nxera’s NxWave™
platform and evaluated through rigorous translational and
preclinical studies. HTL0039732 works by blocking signaling through
a specific type of prostaglandin receptor, the prostaglandin E2
(PGE2)-type prostanoid receptor 4 (EP4). PGE2 acts in the tumor
microenvironment to trigger cancer cells to evade the immune
system. Targeting EP4 to block the effects of PGE2 increases the
ability of the immune system to detect and control cancer cells and
makes HTL0039732 a potential candidate to treat patients with
cancers that generally do not respond well to current
immunotherapies.
Cancer Research UK’s Centre for Drug Development
is sponsoring and managing the trial, which is led by chief
investigator Dr Bristi Basu, University of Cambridge, and Dr
Sarker. The first patient was dosed in August 2023 and the trial is
currently open for recruitment at Addenbrooke’s Hospital in
Cambridge, Guy’s Hospital in London, and the Christie Hospital in
Manchester.
Dr. Debashis Sarker says: “We
are excited to present this ‘Trials in Progress’ poster at ESMO,
outlining the scientific rationale and design of the clinical trial
of HTL0039732, given alone and in combination with immunotherapy
for patients with advanced solid cancers. HTL0039732 targets an
important protein within the tumor immune microenvironment called
EP4, triggering cancer cells to evade the immune system. Targeting
EP4 potentially increases the ability of the immune system to
detect and control cancer cells. Enrolment to the trial began in
the UK in August 2023 and is ongoing across multiple cancer
types.
“We are hopeful that this trial will identify a
novel way to target the immune system and improve treatment options
for patients with a range of different solid cancers.”
–END–
About Nxera PharmaNxera Pharma
(formerly Sosei Heptares) is a technology powered biopharma
company, in pursuit of new specialty medicines to improve the lives
of patients with unmet needs in Japan and globally.
In addition to several products being
commercialized in Japan, we are advancing an extensive pipeline of
over 30 active programs from discovery through to late clinical
stage internally and in partnership with leading pharma and biotech
companies. This pipeline is focused on addressing major unmet needs
in some of the fastest-growing areas of medicine across neurology,
GI and immunology, metabolic disorders and rare diseases, and
leverages the power of our unique and industry leading
GPCR-targeted structure-based drug discovery “NxWaveTM” platform to
provide a sustainable source of best- or first-in-class
candidates.
Nxera employs over 350 talented people at key
locations in Tokyo and Osaka (Japan), London and Cambridge (UK),
Basel (Switzerland) and Seoul (South Korea) and is listed on the
Tokyo Stock Exchange (ticker: 4565).
For more information, please visit
www.nxera.lifeLinkedIn: @NxeraPharma | X: @NxeraPharma | YouTube:
@NxeraPharma
About Cancer Research UK’s Centre for
Drug DevelopmentCancer Research UK has an impressive
record of developing novel treatments for cancer. The Cancer
Research UK Centre for Drug Development has been pioneering the
development of new cancer treatments for 30 years, taking over 160
potential new anti-cancer agents into clinical trials in patients.
Six of these new agents have made it to market, including
temozolomide for brain cancer, abiraterone for prostate cancer and
rucaparib for ovarian cancer. Two other drugs are in late
development Phase 3 trials. Thirteen agents remain in active
development with the potential to reach the market. It
currently has a portfolio of 16 projects in preclinical
development, Phase 1 or early Phase 2 clinical trials.
www.cruk.org.uk/cdd
Enquiries:
For Nxera – Media and Investor
RelationsKentaro Tahara, VP Investor Relations and
Corporate StrategyShinichiro Nishishita, VP Investor Relations,
Head of Regulatory DisclosuresMaya Bennison, Communications
Manager+81 (0)3 5210 3399 | +44 (0)1223 949390 |IR@Nxera.life
For Nxera – MEDiSTRAVA (for
International Media)Mark Swallow, Frazer Hall, Erica
Hollingsworth+44 (0)203 928 6900 | Nxera@medistrava.com
For Cancer Research UKTim
Bodicoat, Content Managertim.bodicoat@cancer.org.uk
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and commercialization of products. Various risks may cause Nxera
Pharma Group’s actual results to differ materially from those
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whether as a result of new information, future events or
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1 A “Trial in Progress” presentation describes the rationale
behind and design of a clinical trial. No data will be
presented.