RNS Number:0049E
Tepnel Life Sciences PLC
19 November 2002


TEPNEL LIFE SCIENCES PLC ("the Company")

19 November 2002

HOLDING IN COMPANY

The Company received notification on 15 November 2002 from Framlington
Investment Management Limited that they are interested in 11,200,000 ordinary
shares of 1p each in the Company ("Shares") representing approximately 11.51% of
the Company's issued shares.

These Shares are registered as follows:
HSBC Nominees Ltd A/C 811664                                       10,800,000
HSBC Nominees Ltd A/C 896177                                          400,000

The previously notified holding announced on 19 July 2002 was 12,475,000 Shares,
representing 12.82% of the then, number of ordinary shares issued.


                      This information is provided by RNS
            The company news service from the London Stock Exchange
END
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