TIDMTED 
 
RNS Number : 5145M 
Gen-Probe Incorporated 
30 January 2009 
 

Not for release, publication or distribution, in whole or in part, in, into or 
from any jurisdiction where to do so would constitute a violation of the 
relevant laws of such jurisdiction 
 
 
30 January 2009 
 
 
RECOMMENDED CASH OFFER FOR TEPNEL LIFE SCIENCES PLC 
 
 
Summary 
 
 
  *  The Gen-Probe Directors and Tepnel Directors are pleased to announce that they 
  have reached agreement on the terms of a recommended cash offer to be made by 
  Gen-Probe for the entire issued and to be issued share capital of Tepnel. It is 
  intended that the Offer will be effected by means of a scheme of arrangement 
  under the Companies Act 2006. 
 
 
 
  *  Under the terms of the Offer, Tepnel Shareholders will receive 27.1 pence in 
  cash for each Tepnel Share. 
 
 
 
  *  The Offer values each Tepnel Share at 27.1 pence and the fully diluted share 
  capital of Tepnel at approximately GBP92.8 million ($132.2 million). 
 
 
 
  *  The Offer represents a premium of approximately: 
 
 
 
  *  125.8 per cent. to the closing price of Tepnel Shares of 12.0 pence per Tepnel 
  Share on 21 January 2009, being the last business day immediately prior to the 
  announcement by Tepnel that it had received an approach; and 
 
 
 
  *  162.4 per cent. to 10.3 pence, being the average closing price per Tepnel Share 
  over the 12 months prior to 21 January 2009. 
 
 
 
  *  Gen-Probe (NASDAQ: GPRO), based in San Diego, California, is a global leader in 
  the development, manufacture and marketing of rapid, accurate and cost-effective 
  nucleic acid probe-based products used primarily for the clinical diagnosis of 
  human diseases and for screening donated human blood. 
 
 
 
  *  Tepnel (AIM: TED) is a UK-based international life sciences products and 
  services group with two divisions, Molecular Diagnostics and Research Products & 
  Services. The Company has laboratories, manufacturing and operations in the USA, 
  UK, France and Belgium with over 200 employees. Tepnel provides test kits, 
  reagents and services to two highly synergistic markets, Molecular Diagnostics 
  and Biomedical Research. 
 
 
 
  *  The acquisition of Tepnel will allow Gen-Probe to enter the human leukocyte 
  antigen, or HLA, and genetic testing segments. HLA testing, frequently conducted 
  prior to transplantation and in the ongoing monitoring of transplant recipients, 
  represents a significant product expansion area for Gen-Probe. In addition, 
  Tepnel brings established pharmaceutical relationships and an opportunity for 
  Gen-Probe to expand into the area of companion diagnostics. Gen-Probe further 
  anticipates that its established capabilities in the research and development of 
  novel diagnostics will help Tepnel accelerate its molecular diagnostics 
  activities, including in the area of genetic testing for inherited disorders. 
  Tepnel also contributes to Gen-Probe's goal of expansion outside the United 
  States.  On a non-GAAP basis, Gen-Probe expects the acquisition to be neutral to 
  the Company's 2009 EPS, and accretive to its 2010 EPS. 
 
 
 
  *  The Tepnel Directors, who have been so advised by Seymour Pierce, consider the 
  terms of the Offer to be fair and reasonable. In providing their advice to the 
  Tepnel Directors, Seymour Pierce have taken into account the commercial 
  assessments of the Tepnel Directors. In addition, the Tepnel Directors consider 
  the terms of the Offer to be in the best interests of Tepnel Shareholders as a 
  whole. 
 
 
 
  *  Accordingly, the Tepnel Directors intend unanimously to recommend that Tepnel 
  Shareholders vote in favour of the Scheme and the resolutions at the Court 
  Meeting and the GM as the Tepnel Directors have irrevocably undertaken to do in 
  respect of their own beneficial holdings, representing as at the date of this 
  announcement, in aggregate, approximately 4 per cent. of the existing issued 
  share capital of Tepnel. 
 
 
 
  *  Gen-Probe has received irrevocable undertakings from certain institutional 
  shareholders to vote in favour of the Scheme and the resolutions at the Court 
  Meeting and the GM in respect of their entire holdings representing, in 
  aggregate, approximately 36 per cent. of the existing issued share capital of 
  Tepnel. Gen-Probe has therefore received total irrevocable undertakings in 
  respect of Tepnel Shares representing approximately 40 per cent. of the existing 
  issued share capital of Tepnel. 
 
 
 
  *  Gen-Probe has also received irrevocable undertakings from certain Tepnel 
  Directors and certain institutional shareholders to exercise Tepnel Share 
  Warrants conditional upon the sanction of the Scheme by the Court representing 
  approximately, in aggregate, 16 per cent. of the diluted share capital of 
  Tepnel. 
 
 
 
  *  The Offer will be put to Tepnel Shareholders at the Court Meeting and at the GM. 
  In order to become effective, the Scheme must be approved by a majority in 
  number of the holders of Tepnel Shares present and voting, either in person or 
  by proxy, representing at least 75 per cent. in value of the Tepnel Shares held 
  by such Tepnel Shareholders at the Court Meeting. In addition, a special 
  resolution implementing the Scheme and approving the related reduction of 
  capital must be passed by Tepnel Shareholders representing 75 per cent. of the 
  votes cast at the GM. The special resolution proposed at the GM will also 
  approve related amendments to the articles of association of Tepnel and to 
  certain of the Tepnel Share Schemes. 
 
 
 
  *  It is expected that the Scheme Document containing further details of the Offer 
  will be posted on or around 21 February 2009. The Scheme will be subject, inter 
  alia, to the satisfaction or waiver of the conditions set out in Appendix I to 
  this announcement and in the Scheme Document. 
 
 
 
  *  It is expected that the Court Meeting and the General Meeting will be held on or 
  around 16 March 2009 and that the Scheme will become effective on or around 8 
  April 2009. 
 
 
 
Henry Nordhoff, Chairman and CEO of Gen-Probe, said: 
 
 
"We believe our acquisition of Tepnel will provide us immediate access to 
attractive growth opportunities in transplant diagnostics, genetic testing and 
pharmaceutical services, and accelerate our ongoing strategic efforts to 
strengthen our marketing and sales, distribution and manufacturing capabilities 
in Europe. We look forward to working with the employees and customers of Tepnel 
to broaden the use of their innovative technologies and expand on their many 
successes to date." 
 
 
Ben Matzilevich, CEO of Tepnel, said: 
 
 
"We believe Gen-Probe's offer represents significant value for 
Tepnel Shareholders and recognizes both our past achievements and our future 
potential in molecular diagnostics and pharmaceutical services. In addition, we 
are excited about the opportunity to accelerate our strategic plans as part of 
one of the most established and highly respected molecular diagnostics companies 
in the world." 
 
 
Merrill Lynch is acting as sole financial adviser and corporate 
broker to Gen-Probe. Seymour Pierce is acting as sole financial adviser and 
corporate broker to Tepnel. 
 
 
This summary should be read in conjunction with, and is subject to, the full 
text of the following announcement and the Appendices. The Offer will be subject 
to the conditions set out in Appendix I to this announcement. Appendix II to 
this announcement contains the bases and sources of certain information 
contained in this announcement. Appendix III to this announcement contains 
details of the irrevocable undertakings. Appendix IV to this announcement 
contains a description of the principal terms of the Implementation Agreement. 
Appendix V contains the definitions of certain terms used in this summary. 
 
 
 
 
Enquiries: 
 
 
+---------------------------------------------+----------------------------+ 
| GEN-PROBE INCORPORATED                      | Telephone: +1 858 410 8000 | 
| Herm Rosenman, Senior Vice President and    |                            | 
| Chief Financial Officer                     |                            | 
| Michael Watts, Senior Director, Investor    |                            | 
| Relations                                   |                            | 
|                                             |                            | 
+---------------------------------------------+----------------------------+ 
| MERRILL LYNCH INTERNATIONAL                 | Telephone: +1 415 676 3401 | 
| (Financial Adviser and Corporate Broker     | Telephone: +44 207 995     | 
| to Gen-Probe)                               | 2000                       | 
| San Francisco                               |                            | 
| Mark Robinson                               |                            | 
| Glenn Rewick                                |                            | 
| London                                      |                            | 
| Jamie Heath                                 |                            | 
|                                             |                            | 
+---------------------------------------------+----------------------------+ 
| TEPNEL LIFE SCIENCES PLC                    | Telephone: +44 161 946     | 
| Ben Matzilevich, Chief Executive Officer    | 2200                       | 
| Michael Slater, Group Finance Director      |                            | 
|                                             |                            | 
+---------------------------------------------+----------------------------+ 
| Seymour Pierce LIMITED                      | Telephone: +44 207 107     | 
| (Financial Adviser and Corporate Broker to  | 8000                       | 
| Tepnel)                                     |                            | 
| Mark Percy                                  |                            | 
| Tom Sheldon                                 |                            | 
| Christopher Wren                            |                            | 
+---------------------------------------------+----------------------------+ 
 
 
Merrill Lynch is acting exclusively for Gen-Probe and no one else in connection 
with the Offer and this announcement and will not be responsible to anyone other 
than Gen-Probe for providing the protections afforded to clients of Merrill 
Lynch or for providing advice in connection with the Offer or any matter 
referred to herein. 
Seymour Pierce, which is authorised and regulated by the Financial Services 
Authority, is acting exclusively for Tepnel and no one else in connection with 
the Offer and will not be responsible to anyone other than Tepnel for providing 
the protections afforded to clients of Seymour Pierce or for providing advice in 
connection with the Offer or any matter referred to herein. 
This announcement is for information purposes only and does not constitute an 
offer to sell or invitation to purchase any securities or the solicitation of 
any vote for approval in any jurisdiction, nor shall there be any sale, issue or 
transfer of the securities referred to in this announcement in any jurisdiction 
in contravention of applicable law. Any response in relation to the Offer should 
be made only on the basis of the information contained in the Scheme Document or 
any document by which the Offer is made. This announcement does not constitute a 
prospectus or prospectus equivalent document. 
This announcement has been prepared for the purpose of complying with English 
law and the City Code and the information disclosed may not be the same as that 
which would have been disclosed if this announcement had been prepared in 
accordance with the laws of jurisdictions outside the United Kingdom. The 
release, publication or distribution of this announcement in certain 
jurisdictions may be restricted by law. Persons who are not resident in the 
United Kingdom or who are subject to other jurisdictions should inform 
themselves of, and observe, any applicable requirements. 
Shareholders in the United States should note that the Scheme relates to the 
shares of a UK company and will be governed by English law. Neither the proxy 
solicitation nor the tender offer rules under the US Securities Exchange Act of 
1934, as amended, will apply to the Scheme. Moreover, the Scheme will be subject 
to the disclosure requirements and practices applicable in the UK to schemes of 
arrangement, which differ from the disclosure requirements of the US proxy 
solicitation rules and tender offer rules. Financial information included in 
this announcement and the Scheme documentation with respect to Tepnel has been 
or will have been prepared in accordance with IFRS and may not be comparable to 
financial information of US companies or companies whose financial statements 
are prepared in accordance with US GAAP. 
If the Offer is carried out by way of an offer, the Offer will not be made, 
directly or indirectly, in, into or from a Restricted Jurisdiction where to do 
so would violate the laws in that jurisdiction, and the Offer will not be 
capable of acceptance from or within a Restricted Jurisdiction. Accordingly, 
copies of this announcement and all documents relating to the Offer are not 
being, and must not be, directly or indirectly, mailed or otherwise forwarded 
(including, without limitation, by telex, facsimile transmission, telephone, 
internet or other forms of electronic communication), distributed or sent in, 
into or from a Restricted Jurisdiction where to do so would violate the laws in 
that jurisdiction, and persons receiving this announcement and all documents 
relating to the Offer (including custodians, nominees and trustees) must not 
mail or otherwise distribute or send them in, into or from such jurisdictions as 
doing so may invalidate any purported acceptance of the Offer. The availability 
of the Offer to Tepnel Shareholders who are not resident in the United Kingdom 
may be affected by the laws of the relevant jurisdictions in which they are 
resident. Persons who are not resident in the United Kingdom should inform 
themselves of, and observe, any applicable requirements. 
Tepnel will prepare the Scheme Document to be distributed to Tepnel 
Shareholders. Tepnel and Gen-Probe urge Tepnel Shareholders to read the Scheme 
Document when it becomes available because it will contain important information 
relating to the Offer. 
No listing authority or equivalent has reviewed, approved or disapproved of this 
announcement or any of the proposals described herein. 
 
 
Forward Looking Statements 
This announcement contains statements about Gen-Probe and Tepnel that are or may 
be forward looking statements. All statements other than statements of 
historical facts included in this announcement may be forward looking 
statements. Without limitation, any statements preceded or followed by or that 
include the words "targets", "plans" "believes", "expects", "aims"," intends", 
"will", "may", "anticipates", "estimates", "projects" or, words or terms of 
similar substance or the negative thereof, are forward looking statements. 
Forward looking statements include statements relating to the following: 
statements relating to the expected benefits of the acquisition to 
Gen-Probe, background and reasons for the offer, expectations of the impact of 
the acquisition on revenue and earnings of Gen-Probe, information on the 
prospects of Gen-Probe or Tepnel future capital expenditures, expenses, 
revenues, earnings, synergies, economic performance, and future prospects. 
Such forward looking statements involve risks and uncertainties that could 
significantly affect expected results and are based on certain key assumptions. 
Many factors could cause actual results to differ materially from those 
projected or implied in any forward looking statements, including risks relating 
to the successful integration of Tepnel with Gen-Probe; higher than anticipated 
costs relating to the integration of Tepnel or investment required in Tepnel to 
realise expected benefits and facts relating to Tepnel that may impact the 
timing or amount of benefit realised from the acquisition that are unknown to 
Gen-Probe. For information identifying additional factors that could cause 
Gen-Probe's actual results to differ from those anticipated in this 
announcement, see Gen-Probe's filings with the United States Securities and 
Exchange Commission (SEC) as updated from time to time, including the risk 
factors discussed in Gen-Probe's annual report on Form 10-K for the fiscal year 
ended 31 December 2007 and its other filings with the SEC. Due to such 
uncertainties and risks, readers are cautioned not to place undue reliance on 
such forward looking statements, which speak only as of the date hereof. 
Gen-Probe and Tepnel disclaim any obligation to update any forward looking or 
other statements contained herein, except as required by applicable law. 
Dealing Disclosure Requirements 
Under the provisions of Rule 8.3 of the Code, if any person is, or becomes, 
"interested" (directly or indirectly) in 1 per cent. or more of any class of 
"relevant securities" of Tepnel, all "dealings" in any "relevant securities" of 
Tepnel (including by means of an option in respect of, or a derivative 
referenced to, any such "relevant securities") must be publicly disclosed by no 
later than 3.30 p.m. (London time) on the Business Day following the date of the 
relevant transaction. This requirement will continue until the date on which the 
Scheme becomes effective or lapses or on which the "offer period" otherwise 
ends. If two or more persons act together pursuant to an agreement or 
understanding, whether formal or informal, to acquire an "interest" in "relevant 
securities" of Tepnel, they will be deemed to be a single person for the purpose 
of Rule 8.3. 
Under the provisions of Rule 8.1 of the Code, all "dealings" in "relevant 
securities" of Tepnel by Gen-Probe or Tepnel, or by any of their respective 
"associates", must be disclosed by no later than 12.00 noon (London time) on the 
Business Day following the date of the relevant transaction. 
A disclosure table, giving details of the companies in whose "relevant 
securities" "dealings" should be disclosed, and the number of such securities in 
issue, can be found on the Panel's website at www.thetakeoverpanel.org.uk. 
"Interests in securities" arise, in summary, when a person has long economic 
exposure, whether conditional or absolute, to changes in the price of 
securities. In particular, a person will be treated as having an "interest" by 
virtue of the ownership or control of securities, or by virtue of any option in 
respect of, or derivative referenced to, securities. 
Terms in quotation marks are defined in the Code, which can also be found on the 
Panel's website. If you are in any doubt as to whether or not you are required 
to disclose a "dealing" under Rule 8, please contact an independent financial 
adviser authorised under the Financial Services and Markets Act 2000, consult 
the Panel's website at www.thetakeoverpanel.org.uk or contact the Panel on 
telephone number +44 (0) 20 7638 0129; fax +44 (0) 20 7236 7013. 
 
 
Not for release, publication or distribution, in whole or in part, in, into or 
from any jurisdiction where to do so would constitute a violation of the 
relevant laws of such jurisdiction 
 
 
30 January 2009 
 
 
RECOMMENDED CASH OFFER FOR TEPNEL LIFE SCIENCES PLC 
 
 
1.  Introduction 
 
 
The Gen-Probe Directors and the Tepnel Directors are pleased to announce that 
they have reached agreement on the terms of a recommended cash offer to be made 
by Gen-Probe for the entire issued and to be issued share capital of Tepnel. It 
is intended that the Offer will be effected by means of a scheme of arrangement 
under the Companies Act 2006. 
 
 
Merrill Lynch is acting as sole financial adviser and corporate broker to 
Gen-Probe. Seymour Pierce is acting as sole financial adviser and corporate 
broker to Tepnel. 
 
 
2.  The Offer 
 
 
Under the Scheme (which will be subject to the conditions and further terms set 
out below, in Appendix I to this announcement and in the Scheme Document) Tepnel 
Shareholders will be entitled to receive: 
 
 
    for each Tepnel Share27.1 pence in cash 
 
 
The Offer values each Tepnel Share at 27.1 pence and the existing issued 
ordinary share capital of Tepnel at approximately GBP92.8 million ($132.2 
million). 
 
Tepnel Shareholders will receive 27.1 pence per Tepnel Share in cash within 
14 days of the Effective Date. The consideration each Tepnel Shareholder will 
receive pursuant to the Offer will be rounded up to the nearest penny. 
 
 
The Offer represents a premium of approximately: 
 
 
  *  125.8 per cent. to the closing price of Tepnel Shares of 12.0 pence per Tepnel 
  Share on 21 January 2009, being the last business day immediately prior to the 
  announcement by Tepnel that it had received an approach; and 
 
 
 
  *  162.4 per cent. to 10.3 pence, being the average closing price per Tepnel Share 
  over the 12 months prior to 21 January 2009. 
 
 
 
The Tepnel Shares will be acquired pursuant to the Offer fully paid and free 
from all liens, charges, equitable interests, encumbrances, rights of 
pre-emption and any other rights and interests of any nature whatsoever and 
together with all rights now and hereafter attaching thereto, including voting 
rights and the right to receive and retain in full all dividends and other 
distributions (if any) declared, made or paid on or after the date of this 
announcement. 
 
 
It is expected that the Scheme Document will be posted on or around 21 February 
2009 and that the Court Meeting and the General Meeting will be held on or 
around 16 March 2009 and that the Scheme will become effective on or around 8 
April 2009. 
 
 
3.  Background to and reasons for the Offer 
 
 
The acquisition of Tepnel allows Gen-Probe to expand into the areas of HLA 
testing, genetic testing,  pharmaceutical services and companion diagnostics, 
while allowing Tepnel to benefit from Gen-Probe's established capabilities in 
developing and commercializing novel molecular diagnostics. Tepnel also furthers 
 Gen-Probe's goal of expansion outside the United States. 
 
 
Gen-Probe anticipates that Tepnel's human leukocyte antigens testing products 
will facilitate its diversification into the transplant typing market. HLA 
testing is used to match donors and recipients in anticipation of transplant 
surgeries, as well as in the ongoing management of transplant recipients. Tepnel 
brings an established position in the segment with strong opportunities for 
continued growth. The company sells xMAP  multiplex assays in the field of 
transplant diagnostics under its development and supply agreement with Luminex. 
The worldwide market for HLA tests is estimated at $260 million in 2008, and is 
forecast to grow at a low-double-digit rate. 
 
 
Gen-Probe believes that Tepnel's genetic disease testing business is 
complementary to its molecular diagnostics activities. Tepnel sells genetic 
tests for cystic fibrosis, Down's syndrome and familial hypercholesterolemia, 
among others. The companies anticipate that Gen-Probe's proven record in the 
development of novel diagnostics, its premier commercialization capabilities, 
and its reputation within the clinical community will help accelerate Tepnel's 
molecular diagnostics activities. 
 
 
Tepnel's pharmaceutical services business has master service agreements with a 
number of major pharmaceutical clients, and Gen-Probe believes its ownership of 
Tepnel will further strengthen these relationships. In addition, Tepnel's 
activities in this segment provide Gen-Probe an opportunity to expand into the 
rapidly emerging market for companion diagnostics. 
 
 
Tepnel has a solid financial track record with a product portfolio and pipeline 
to support continued revenue growth for Gen-Probe. Tepnel experienced compound 
annual revenue growth of 20.5 per cent. from 2004 to 2007 and has been 
profitable since 2006. With approximately 60 per cent. of 2007 revenues coming 
from Europe, the combination with Tepnel is expected to accelerate Gen-Probe's 
expansion of activities outside of the US. 
 
 
The acquisition is expected to be approximately neutral to non-GAAP EPS in 2009 
without synergies, and increasingly accretive to non-GAAP EPS in 2010 and 
beyond. 
 
 
4.  Recommendation 
 
 
The Tepnel Directors, who have been so advised by Seymour Pierce, consider the 
terms of the Offer to be fair and reasonable. In providing their advice to the 
Tepnel Directors, Seymour Pierce have taken into account the commercial 
assessments of the Tepnel Directors. In addition, the Tepnel Directors consider 
the terms of the Offer to be in the best interests of Tepnel Shareholders as a 
whole. 
 
 
Accordingly, the Tepnel Directors intend unanimously to recommend that Tepnel 
Shareholders vote in favour of the Scheme and the resolutions at the Court 
Meeting and the GM as the Tepnel Directors have irrevocably undertaken to do in 
respect of their own beneficial holdings of 9,235,783 Tepnel Shares, 
representing as at the date of this announcement, in aggregate, approximately 4 
per cent. of the existing issued share capital of Tepnel. 
 
 
 
 
 
5.  Background to and reasons for the recommendation 
 
 
Following the strategic reorganisation and integration of the businesses 
acquired in 2004, the  Tepnel  management  team has transformed Tepnel through 
building leadership positions in defined markets in the Molecular Diagnostics 
and Research Products and Services sectors. 
 
 
The Molecular Diagnostics division is focused on key growth markets, principally 
organ transplant monitoring and foetal distress diagnostics, and developing 
products which utilise its technologies for new markets, including the blood 
bank market. The Tepnel Directors believe that the Research Products and 
Services division, through significant investment in a new pharmaceutical 
services facility in Livingston, Scotland, and recently launched services, is 
well placed to access the growing Biopharmaceutical and genotyping markets. 
 
 
Whilst the strategy of the Tepnel board has been successful to date, the Tepnel 
Directors are cognizant that in future years Tepnel will require additional 
capital expenditure, access to certain technologies and an expansion of its 
capabilities, particularly in sales and marketing, which the Tepnel Directors 
believe can be better provided by Gen-Probe, one of the most highly respected 
molecular diagnostics companies in the world. 
 
 
Notwithstanding the significant achievements of Tepnel over the last few years, 
having considered all relevant factors, including the views of a number of major 
Tepnel Shareholders and the advice of Seymour Pierce, Tepnel's financial 
advisers, the Tepnel Directors believe that the offer price of 27.1 pence  per 
Tepnel Share reflects Tepnel's  strong future prospects and growth opportunities 
and represents an opportunity for  Shareholders to receive a fair cash price now 
which might otherwise have been difficult to obtain in the short to medium term. 
 
 
The Offer represents a substantial premium of approximately 125.8 per cent. to 
the closing price of Tepnel Shares of 12.0 pence per Tepnel Share on 21 January 
2009, being the last business day immediately prior to the announcement by 
Tepnel that it had received an approach. 
 
 
6.  Irrevocable undertakings 
 
 
Gen-Probe has received irrevocable undertakings from each of the Tepnel 
Directors to vote in favour of the Scheme and the resolutions at the Court 
Meeting and the GM in respect of their own beneficial holdings, representing 
approximately 4 per cent. of the existing issued share capital of Tepnel. 
 
 
Gen-Probe has received irrevocable undertakings from certain institutional 
shareholders to vote in favour of the Scheme and the resolutions at the Court 
Meeting and the GM in respect of their entire holdings, representing 
approximately 36 per cent. of the existing issued share capital of Tepnel. 
Gen-Probe has therefore received total irrevocable undertakings in respect of 
Tepnel Shares representing approximately  40 per cent. of the existing issued 
share capital of Tepnel. 
 
 
Gen-Probe has also received irrevocable undertakings from certain Tepnel 
Directors and certain institutional shareholders to exercise Tepnel Share 
Warrants conditional upon the sanction of the Scheme by the Court, representing 
approximately, in aggregate, 16 per cent. of the diluted share capital of 
Tepnel. 
 
 
Further details of these irrevocable undertakings are set out in Appendix III to 
this announcement. 
 
 
7.  Information on Gen-Probe 
 
 
Gen-Probe Incorporated (NASDAQ: GPRO), based in San Diego, California, is a 
global leader in the development, manufacture and marketing of rapid, accurate 
and cost-effective nucleic acid probe-based products used primarily for the 
clinical diagnosis of human diseases and for screening donated human blood. 
 
 
For the financial year ended 31 December 2007, Gen-Probe reported revenues of 
$403.0 million (2006: $354.8 million) and net income of $86.1 million (2006: 
$59.5 million) and had total assets as at that date of $789.1 million. For the 
nine months ended 30 September 2008, Gen-Probe reported revenues of $363.6 
million and net income of $85.8 million and had total assets as of that date of 
$909.2 million. Gen-Probe is listed on the NASDAQ Global Market and as at 
29 January 2009 had a market capitalisation of approximately $2,495 million. 
Gen-Probe's financial results are reported under US generally accepted 
accounting principles (US GAAP) which differ from financial reporting standards 
adopted by the European Union (IFRS). 
 
 
8.  Information on Tepnel 
 
 
Tepnel (AIM: TED) is a UK-based international life sciences products and 
services group with two divisions, Molecular Diagnostics and Research Products & 
Services. The Company has laboratories, manufacturing and operations in the USA, 
UK, France and Belgium with over 200 employees. Tepnel provides test kits, 
reagents and services to two highly synergistic markets, Molecular Diagnostics 
and Biomedical Research.. 
 
 
For the year ended 31 December 2007, Tepnel reported revenues from continuing 
operations of GBP17.8 million (2006: GBP15.0 million) and profit on ordinary 
activities before taxation of GBP1.27 million (2006: loss of GBP0.02  million) 
and had net assets as at that date of GBP8.6 million. Tepnel is listed on AIM, a 
market operated by the London Stock Exchange. Tepnel's financial results are 
reported under IFRS, which differ from US GAAP. 
 
 
9.  Current trading and prospects of the Tepnel Group 
 
 
On 31 July 2008, Tepnel announced its unaudited interim results for the six 
months ended 30 June 2008, which disclosed profits on ordinary activities before 
tax of GBP1.4 million (GBP0.6 million for the six months ended 30 June 2007) on 
turnover of GBP11.8 million (GBP8.8 million for the six months ended 30 June 
2007). Net assets increased from GBP7.7 million as at 30 June 2007 to GBP10.1 
million as at 30 June 2008 with cash and short-term deposits of GBP3.7 million 
(2007: GBP2.4 million). 
 
 
Since 31 July 2008, Tepnel's trading has proceeded in line with existing 
management's expectations. The Board of Tepnel believes that the significant 
investment made in Tepnel's new facilities and its new product and services 
development provides a positive outlook for the business. 
 
 
10.  Structure of the Offer 
 
 
It is intended that the Offer is to be effected by means of a scheme of 
arrangement between Tepnel and its Shareholders under the Companies Act 2006. 
 
 
The purpose of the Scheme is to enable Gen-Probe to become the owner of the 
whole of the issued ordinary share capital of Tepnel. This is to be achieved 
by the cancellation of the Scheme Shares and the application of the reserve 
arising from such cancellation in paying up in full a number of new shares in 
Tepnel (which is equal to the number of Scheme Shares cancelled) and issuing 
them to Gen-Probe, in consideration for which the holders of the Scheme Shares 
will receive cash on the basis set out in paragraph 2 of this announcement. 
 
 
To become effective, the Scheme requires, amongst other things, the approval by 
a majority in number of the Tepnel Shareholders representing at least 75 per 
cent. in value of all Tepnel Shares held by such Tepnel Shareholders voted, 
either in person or by proxy, at the Court Meeting, together with the sanction 
of the Court and the passing of a special resolution necessary to implement the 
Scheme at the GM. The special resolution will also approve related amendments to 
the articles of association of Tepnel and certain of the Tepnel Share Schemes. 
Upon the Scheme becoming effective, it will be binding on all Tepnel 
Shareholders, irrespective of whether or not they attended or voted at the Court 
Meeting or the General Meeting. The Scheme is expected to be effective on or 
around 8 April 2009. 
 
 
The conditions to the Offer are set out in full in Appendix I to this 
announcement. The Scheme is conditional, inter alia, upon: 
 
 
  *  the Scheme becoming effective by not later than four months from the posting of 
  the Scheme Document or such later date as Tepnel and Gen-Probe may agree and the 
  Court may approve, failing which the Scheme will lapse; 
 
 
 
  *  the approval by a majority in number of the Scheme Shareholders who vote, 
  representing at least 75 per cent. in value of the Scheme Shares voted, either 
  in person or by proxy, at the Court Meeting; 
 
 
 
  *  the passing of the resolution(s) required to implement the Scheme and to amend 
  the articles of association of Tepnel and the terms of certain of the Tepnel 
  Share Schemes; 
 
 
 
  *  the sanction of the Scheme and subsequent confirmation of the Capital Reduction 
  by the Court (in either case, with or without modification on terms agreed by 
  Tepnel and Gen-Probe) and the delivery of office copies of the Court Orders to 
  the Registrar and, in the case of the Capital Reduction, the registration of 
  such Court Order; and 
 
 
 
  *  the conditions, set out in Appendix I to this announcement, which are not 
  otherwise identified above being satisfied or waived. 
 
 
 
It is intended that, prior to the Scheme becoming effective, and subject to 
applicable requirements of the London Stock Exchange and the Financial Services 
Authority, Gen-Probe will procure that Tepnel will apply to the London Stock 
Exchange for the Tepnel Shares to cease trading and to remove the Tepnel Shares 
from their quotation on AIM, in each case with effect from the Effective Date. 
 
 
Subject to the Scheme becoming effective, share certificates in respect of 
Tepnel Shares will cease to be valid on the Effective Date and should be 
destroyed. In addition, on the Effective Date, entitlements to Tepnel Shares 
held within the CREST system will be cancelled. It is also proposed that, 
following the Effective Date and after the Tepnel Shares are delisted, Tepnel 
will be re-registered as a private limited company. 
 
 
Further details of the Scheme will be contained in the Scheme Document. 
 
 
11.  Management and employees 
 
 
Gen-Probe attaches great importance to the skills and experience of the existing 
management and employees of Tepnel. As such, Gen-Probe expects that Tepnel 
employees will play an important role in the enlarged group. 
 
 
Gen-Probe has given the board of Tepnel assurances that, following closing of 
the Offer, the existing employment rights, including pension rights, of the 
management and employees of Tepnel will be safeguarded. Gen-Probe does not 
currently intend to make any material change in the conditions of employment of 
Tepnel employees. 
 
 
12.  Tepnel Share Schemes 
 
 
Participants in any Tepnel Share Schemes will be contacted regarding the effect 
of the Offer on their rights under those schemes and appropriate proposals will 
be made to such participants in due course. Further details of these proposals 
will be set out in separate letters to be sent to participants in the Tepnel 
Share Schemes. 
 
 
13.  Tepnel Share Warrants 
 
 
Holders of any Tepnel Share Warrants will be contacted regarding the effect of 
the Offer on their rights under those warrants and appropriate proposals will be 
made to such holders in due course. Tepnel will amend the Warrant Instrument 
constituting the Warrants to permit holders to exercise their Warrants 
conditional upon sanction of the Scheme by the Court. Further details of these 
proposals will be set out in separate letters to be sent to Tepnel Share Warrant 
holders. 
 
 
14.  Amendments to Articles of Association 
 
 
It is proposed to amend the articles of association of Tepnel at the GM to 
provide that, if the Scheme becomes effective, any Tepnel Shares issued on or 
after the Effective Date of the Capital Reduction will automatically be 
transferred to Gen-Probe in exchange for the Offer Price in cash on the same 
basis as under the Scheme. Consequently, participants in the Tepnel Share 
Schemes or holders of the Tepnel Share Warrants who exercise any options or 
warrants after the Scheme becomes effective will receive the same cash 
consideration as the holders of Scheme Shares who receive the Offer Price under 
the Scheme. 
 
 
15.  Financing 
 
 
The cash consideration payable by Gen-Probe under the terms of the Offer will be 
funded using Gen-Probe's existing cash resources. 
 
 
Merrill Lynch, financial adviser and corporate broker to Gen-Probe, is satisfied 
that sufficient resources are available to satisfy the full cash consideration 
payable to Tepnel Shareholders under the terms of the Offer. 
 
 
16.  Implementation Agreement and Inducement Fee 
 
 
Gen-Probe and Tepnel have entered into the Implementation Agreement dated 30 
January 2009 under the terms of which they have agreed to implement the Scheme. 
 
 
The principal terms of the Implementation Agreement are set out in Appendix IV 
to this Announcement. 
 
 
17.  Disclosure of interests in Tepnel 
 
 
Except as disclosed below, as at 28 January 2009, the last practicable date 
before this announcement, and save for the irrevocable undertakings referred to 
in paragraph 6 above, neither Gen-Probe nor any Gen-Probe Directors nor, so far 
as Gen-Probe is aware, any party acting in concert with Gen-Probe, has any 
interest in, or right to subscribe for, any Tepnel Shares or any Tepnel 
Securities, nor does any such person have any short position (whether 
conditional or absolute and whether in the money or otherwise) including short 
positions under derivatives or arrangement in relation to Tepnel Securities. For 
these purposes, "arrangement" includes any indemnity or option arrangement or 
any agreement or understanding, formal or informal, of whatever nature, relating 
to Tepnel Securities which may be an inducement to deal or refrain from dealing 
in such securities. In the interests of secrecy prior to this announcement, 
Gen-Probe has not made any enquiries in this respect of the matters referred to 
in this paragraph of certain parties who may be deemed by the Panel to be acting 
in concert with them for the purposes of the Scheme. Enquiries of such parties 
will be made as soon as practicable following the date of this announcement and 
any material disclosure in respect of such parties will be included in the 
Scheme Document. 
 
 
+-----------------------------------+------------------+------------------+ 
| Party                             |    Interest in Tepnel securities    | 
+-----------------------------------+-------------------------------------+ 
| Seymour Pierce                    | Long             |      22,240      | 
+-----------------------------------+------------------+------------------+ 
|                                   | Short            |        0         | 
+-----------------------------------+------------------+------------------+ 
|                                   | Net              |      22,240      | 
+-----------------------------------+------------------+------------------+ 
 
 
 18.  General 
 
 
Gen-Probe reserves the right, with the consent of the Panel, to elect to 
implement the Offer by making a takeover offer for the entire issued and to be 
issued share capital of Tepnel. 
 
 
If Gen-Probe elects to implement the Offer by a takeover offer, that offer will 
be implemented on the same terms (subject to appropriate amendments), so far as 
applicable, as those which would apply to the Scheme. Any such takeover offer 
will be subject to a 90 per cent. acceptance condition or such lesser 
percentage, being more than 50 per cent., as Gen-Probe may decide. Furthermore, 
if sufficient acceptances of such offer are received and/or sufficient Tepnel 
Shares are otherwise acquired, it is the intention of Gen-Probe to apply the 
provisions of sections 979 to 982 (inclusive) of the Companies Act 2006 to 
acquire compulsorily any outstanding Tepnel Shares to which such offer relates. 
 
 
Prior to the Scheme becoming effective, Tepnel will make an application to the 
London Stock Exchange to cancel trading in the Tepnel Shares on AIM and to 
cancel the quotation of the Tepnel Shares on the Effective Date. It is also 
proposed that, following the Effective Date and after its shares are delisted, 
Tepnel will be re-registered as a private limited company. 
 
 
The Offer will be made on the terms and subject to the conditions and further 
terms set out herein and in Appendix I to this announcement and to be set out in 
the Scheme Document and the Forms of Proxy. The Scheme Document will include 
full details of the Scheme, together with notices of the Court Meeting and the 
GM and the expected timetable of the Offer. The Scheme Document and the Forms of 
Proxy will be dispatched to Tepnel Shareholders in due course. The Offer will be 
subject to the applicable requirements of the City Code, the Panel, the London 
Stock Exchange and the Financial Services Authority. 
Appendix II to this announcement contains details of the sources of information 
and bases of calculations set out in this announcement. Appendix III to this 
announcement contains details of the irrevocable undertakings that have been 
provided to Gen-Probe. Appendix IV contains a description of the principal terms 
of the Implementation Agreement. Appendix V to this announcement contains 
definitions of certain expressions used in this announcement. 
This announcement does not constitute an offer to sell or an invitation to 
purchase or subscribe for any securities. This announcement also does not 
constitute a prospectus or prospectus equivalent document. 
 
 
Any response in relation to the Offer should be made only on the basis of the 
information contained in the Scheme Document or any document by which the Offer 
is made. The availability of the Offer to persons not resident in the United 
Kingdom may be affected by the laws of the relevant jurisdictions. Persons who 
are not resident in the United Kingdom, or who are subject to the laws of any 
jurisdiction other than the United Kingdom, should inform themselves about and 
observe any applicable requirements of those jurisdictions. 
Shareholders in the United States should note that the Scheme relates to the 
shares of a UK company and will be governed by English law. Neither the proxy 
solicitation nor the tender offer rules under the US Securities Exchange Act of 
1934, as amended, will apply to the Scheme. Moreover, the Scheme will be subject 
to the disclosure requirements and practices applicable in the UK to schemes of 
arrangement, which differ from the disclosure requirements of the US proxy 
solicitation rules and tender offer rules. Financial information included in 
this announcement and the Scheme documentation with respect to Tepnel has been 
or will have been prepared in accordance with IFRS and may not be comparable to 
financial information of US companies or companies whose financial statements 
are prepared in accordance with US GAAP. 
If the Offer is carried out by way of an offer, the Offer will not be made, 
directly or indirectly, in, into or from a Restricted Jurisdiction where to do 
so would violate the laws in that jurisdiction, and the Offer will not be 
capable of acceptance from or within a Restricted Jurisdiction. Accordingly, 
copies of this announcement and all documents relating to the Offer are not 
being, and must not be, directly or indirectly, mailed or otherwise forwarded, 
(including without limitation by telex, facsimile transmission, telephone, 
internet or other forms of electronic communication) distributed or sent in, 
into or from a Restricted Jurisdiction where to do so would violate the laws in 
that jurisdiction, and persons receiving this announcement and all documents 
relating to the Offer (including custodians, nominees and trustees) must not 
mail or otherwise distribute or send them in, into or from such jurisdictions as 
doing so may invalidate any purported acceptance of the Offer. The availability 
of the Offer to Tepnel Shareholders who are not resident in the United Kingdom 
may be affected by the laws of the relevant jurisdictions in which they are 
resident. Persons who are not resident in the United Kingdom should inform 
themselves of, and observe, any applicable requirements. 
Merrill Lynch is acting exclusively for Gen-Probe and no one else in connection 
with the Offer and will not be responsible to anyone other than Gen-Probe for 
providing the protections afforded to clients of Merrill Lynch, or for providing 
advice in connection with the Offer or any matter referred to herein. 
Seymour Pierce, which is authorised and regulated by the Financial Services 
Authority, is acting exclusively for Tepnel and no one else in connection with 
the Offer and will not be responsible to anyone other than Tepnel for providing 
the protections afforded to clients of Seymour Pierce or for providing advice in 
connection with the Offer or any matter referred to herein. 
No listing authority or equivalent has reviewed, approved or disapproved of this 
announcement or any of the proposals described herein. 
Forward Looking Statements 
This announcement contains statements about Gen-Probe and Tepnel that are or may 
be forward looking statements. All statements other than statements of 
historical facts included in this announcement may be forward looking 
statements. Without limitation, any statements preceded or followed by or that 
include the words "targets", "plans", "believes", "expects", "aims", "intends", 
"will", "may", "anticipates", "estimates", "projects" or, words or terms of 
similar substance or the negative thereof, are forward looking statements. 
Forward looking statements include statements relating to the following: 
statements relating to the expected benefits of the acquisition to 
Gen-Probe, background and reasons for the offer, expectations of the impact of 
the acquisition on revenue and earnings of Gen-Probe, information on the 
prospects of Gen-Probe or Tepnel future capital expenditures, expenses, 
revenues, earnings, synergies, economic performance, and future prospects. 
Such forward looking statements involve risks and uncertainties that could 
significantly affect expected results and are based on certain key assumptions. 
Many factors could cause actual results to differ materially from those 
projected or implied in any forward looking statements, including risks relating 
to the successful integration of Tepnel with Gen-Probe; higher than anticipated 
costs relating to the integration of Tepnel or investment required in Tepnel to 
realise expected benefits and facts relating to Tepnel that may impact the 
timing or amount of benefit realised from the acquisition that are unknown to 
Gen-Probe. For information identifying additional factors that could cause 
Gen-Probe's actual results to differ from those anticipated in this 
announcement, see Gen-Probe's filings with the United States Securities and 
Exchange Commission (SEC) as updated from time to time, including the risk 
factors discussed in Gen-Probe's annual report on Form 10-K for the fiscal year 
ended 31 December 2007 and its other filings with the SEC. Due to such 
uncertainties and risks, readers are cautioned not to place undue reliance on 
such forward looking statements, which speak only as of the date hereof. 
Gen-Probe and Tepnel disclaim any obligation to update any forward looking or 
other statements contained herein, except as required by applicable law. 
Dealing Disclosure Requirements 
Under the provisions of Rule 8.3 of the Code, if any person is, or becomes, 
"interested" (directly or indirectly) in 1 per cent. or more of any class of 
"relevant securities" of Tepnel, all "dealings" in any "relevant securities" of 
Tepnel (including by means of an option in respect of, or a derivative 
referenced to, any such "relevant securities") must be publicly disclosed by no 
later than 3.30 p.m. (London time) on the Business Day following the date of the 
relevant transaction. This requirement will continue until the date on which the 
Scheme becomes effective or lapses or on which the "offer period" otherwise 
ends. If two or more persons act together pursuant to an agreement or 
understanding, whether formal or informal, to acquire an "interest" in "relevant 
securities" of Tepnel, they will be deemed to be a single person for the purpose 
of Rule 8.3. 
Under the provisions of Rule 8.1 of the Code, all "dealings" in "relevant 
securities" of Tepnel by Gen-Probe or Tepnel, or by any of their respective 
"associates", must be disclosed by no later than 12.00 noon (London time) on the 
Business Day following the date of the relevant transaction. 
A disclosure table, giving details of the companies in whose "relevant 
securities" "dealings" should be disclosed, and the number of such securities in 
issue, can be found on the Panel's website at www.thetakeoverpanel.org.uk. 
"Interests in securities" arise, in summary, when a person has long economic 
exposure, whether conditional or absolute, to changes in the price of 
securities. In particular, a person will be treated as having an "interest" by 
virtue of the ownership or control of securities, or by virtue of any option in 
respect of, or derivative referenced to, securities. 
Terms in quotation marks are defined in the Code, which can also be found on the 
Panel's website. If you are in any doubt as to whether or not you are required 
to disclose a "dealing" under Rule 8, please contact an independent financial 
adviser authorised under the Financial Services and Markets Act 2000, consult 
the Panel's website at www.thetakeoverpanel.org.uk or contact the Panel on 
telephone number +44 (0) 20 7638 0129; fax +44 (0) 20 7236 7013. 
 
 
Enquiries: 
+---------------------------------------------+----------------------------+ 
| GEN-PROBE INCORPORATED                      | Telephone: +1 858 410 8000 | 
| Herm Rosenman, Senior Vice President and    |                            | 
| Chief Financial Officer                     |                            | 
| Michael Watts, Senior Director, Investor    |                            | 
| Relations                                   |                            | 
+---------------------------------------------+----------------------------+ 
| MERRILL LYNCH INTERNATIONAL                 | Telephone: +1 415 676 3401 | 
| (Financial Adviser and Corporate Broker     |     Telephone: +44 207 995 | 
| to Gen-Probe)                               |                       2000 | 
| San Francisco                               |                            | 
| Mark Robinson                               |                            | 
| Glenn Rewick                                |                            | 
| London                                      |                            | 
| Jamie Heath                                 |                            | 
|                                             |                            | 
+---------------------------------------------+----------------------------+ 
| TEPNEL LIFE SCIENCES PLC                    | Telephone: +44 161 946     | 
| Ben Matzilevich, Chief Executive Officer    | 2200                       | 
| Michael Slater, Group Finance Director      |                            | 
|                                             |                            | 
+---------------------------------------------+----------------------------+ 
| Seymour Pierce LIMITED                      |     Telephone: +44 207 107 | 
| (Financial Adviser and Corporate Broker to  |                       8000 | 
| Tepnel)                                     |                            | 
| Mark Percy                                  |                            | 
| Tom Sheldon                                 |                            | 
| Christopher Wren                            |                            | 
+---------------------------------------------+----------------------------+ 
 
 
  APPENDIX I 
CONDITIONS AND FURTHER TERMS OF THE OFFER 
 
 
Part A: Conditions of the Scheme 
The Offer will be conditional upon the Scheme becoming effective by not later 
than four months from the date that the Scheme Document is posted or such later 
date (if any) as Tepnel and Gen-Probe may agree and (if required) the Court and 
the Panel may allow. 
 
 
1    The Scheme will be conditional upon: 
1.1    the approval of the Scheme by a majority in number representing 75 per 
cent. or more in value of the Scheme Shareholders (or the relevant class or 
classes therof) present and voting, either in person or by proxy, at the Court 
Meeting, or at any adjournment thereof; 
1.2    the resolution(s) in connection with or required to implement the Scheme 
and set out in the notice of the GM being duly passed by the requisite majority 
at the GM, or at any adjournment thereof; and 
1.3    the sanction (with or without modification, on terms agreed by Tepnel and 
Gen-Probe) of the Scheme and confirmation of the Capital Reduction by the Court 
and office copies of the Court Orders and the minute of such Capital Reduction 
attached thereto being delivered for registration to the Registrar and, in 
relation to the Capital Reduction, being registered by the Registrar. 
2    In addition, Tepnel and Gen-Probe have agreed that, subject as stated in 
Part B below, the Scheme will also be conditional upon, and accordingly 
application to the Court to sanction the Scheme and to confirm the Capital 
Reduction will only be made upon conditions 1.1 and 1.2 above having been 
fulfilled and provided that immediately prior to the hearing of the petition to 
sanction the Scheme, the following conditions (as amended if appropriate) are 
satisfied or waived as referred to below: 
2.1    no central bank, government or governmental, quasi-governmental, state or 
local government, supranational, statutory, environmental, administrative, 
investigative or regulatory body, agency, court, association or any other person 
or body in any jurisdiction (a "Relevant Authority") having decided to 
take, having taken, instituted, implemented or threatened any action, 
proceeding, suit, investigation or enquiry, or enacted, made or proposed any 
statute, regulation order, decision, changed a published position or 
otherwise taken any other step that would or might in the opinion of Gen-Probe 
in any respect reasonably be expected to: 
2.1.1    require, prevent or delay the divestiture by any member of the Wider 
Gen-Probe Group or any member of the Wider Tepnel Group of all or any portion of 
their respective businesses, assets or properties or impose any limitation on 
the ability of any member of the Wider Gen-Probe Group or the Wider Tepnel Group 
to conduct their respective businesses (or any part of them) or to own or 
control any of their respective assets or properties or any part of them which, 
in any such case, is material in the context of the Wider Tepnel Group taken as 
a whole or in the context of the Offer; 
2.1.2other than pursuant to the implementation of the Offer require any member 
of either the Wider Gen-Probe Group or Wider Tepnel Group to make an offer to 
acquire any shares or other securities in any member of the Wider Tepnel Group 
owned by any third party; or 
2.1.3    impose any material limitation on, or result in a material delay in, 
the ability of Gen-Probe or the Wider Gen-Probe Group directly or indirectly to 
acquire or to hold or to exercise effectively directly or indirectly all or any 
rights of ownership in respect of shares or loans or securities convertible into 
shares or any other securities (or the equivalent) in Tepnel or the ability of 
Gen-Probe to hold or exercise effectively any rights of ownership of shares, 
loans or other securities in, or to exercise management control over any member 
of the Wider Tepnel Group, which, in any such case, is material in the context 
of the Wider Tepnel Group taken as a whole or in the context of the Offer; 
2.1.4    otherwise adversely affect the business, assets, liabilities, financial 
or trading position, profits or prospects of any member of the Wider Tepnel 
Group in each case to an extent which is material in the context of the Wider 
Tepnel Group taken as a whole or in the context of the Offer; 
2.1.5    result in any member of the Wider Tepnel Group ceasing to be able to 
carry on business under any name under which it presently does so which is 
material in the context of the Wider Tepnel Group taken as a whole or in the 
context of the Offer; or 
2.1.6    make the Scheme or its implementation or the acquisition of any shares 
in, or control of, Tepnel by any member of the Wider Gen-Probe Group, void, 
unenforceable, illegal and/or prohibited in or under the laws of any 
jurisdiction or otherwise directly or indirectly restrict, restrain, prohibit, 
delay or otherwise materially interfere with the implementation of, or impose 
additional conditions or obligations with respect to, or require amendment of, 
or otherwise challenge or interfere with, the Offer, 
and all applicable waiting and other time periods during which any such Relevant 
Authority could decide to take, institute, implement or threaten any such 
action, proceedings, suit, investigation, enquiry or reference or take any other 
step under the laws of any jurisdiction having expired, lapsed or been 
terminated; 
2.2    all necessary filings, applications and/or notifications which are 
necessary or reasonably considered necessary by Gen-Probe having been made and 
all appropriate waiting periods (including any extensions thereof) under any 
applicable legislation or regulation of any jurisdiction having expired, lapsed 
or been terminated in each case in respect of the Offer and the acquisition of 
any shares or other securities in, or control of, Tepnel by Gen-Probe or any 
member of the Wider Gen-Probe Group and all authorisations, orders, grants, 
recognitions, confirmations, licences, consents, clearances, permissions and 
approvals ("authorisations") necessary or appropriate in any jurisdiction for or 
in respect of the Offer and the proposed acquisition of any shares or other 
securities in, or control or management of, Tepnel by Gen-Probe or any member of 
the Wider Gen-Probe Group being obtained in terms and in a form satisfactory to 
Gen-Probe, acting reasonably, from appropriate Relevant Authorities or from any 
persons or bodies with whom any member of the Wider Gen-Probe Group or the Wider 
Tepnel Group has entered into contractual arrangements and such authorisations 
together with all authorisations necessary or appropriate for any member of the 
Wider Tepnel Group to carry on its business remaining in full force and effect 
in each case where the absence of such authorisation would have a material 
adverse effect on the Wider Tepnel Group and there being no notice or other 
intimation of any intention to revoke, suspend, restrict or modify or not to 
renew any of the same having been made and all necessary statutory or regulatory 
obligations in any jurisdiction having been complied with; 
2.3    save as fairly disclosed in the Annual Report or as Publicly Announced or 
fairly disclosed in writing to Gen-Probe or its advisers by or on behalf of 
Tepnel in the course of the negotiations relating to the Offer, in each case 
prior to the date of this announcement, there being no provision of any 
arrangement, agreement, lease, licence, permit or other instrument to which any 
member of the Tepnel Group is a party or by or to which any such member or any 
of its assets is or may be bound or be subject which, as a consequence of the 
Offer or the acquisition or the proposed acquisition by Gen-Probe or any member 
of the Wider Gen-Probe Group of any shares or other securities (or the 
equivalent) in Tepnel or because of a change in the control or management of any 
member of the Wider Tepnel Group or otherwise, would or might reasonably be 
expected to result in, in any case to an extent which is material in the context 
of the Wider Tepnel Group taken as a whole or in the context of the Offer in: 
2.3.1    any monies borrowed by, or any other indebtedness, actual or 
contingent, of, or any grant available to, any member of the Wider Tepnel Group 
being or becoming repayable, or being capable of being declared repayable 
immediately or prior to their or its stated maturity, or the ability of any such 
member to borrow monies or incur any indebtedness being withdrawn or inhibited 
or becoming capable of being withdrawn or inhibited; 
2.3.2    the creation or enforcement of any mortgage, charge or other security 
interest, over the whole or any part of the business, property or assets of any 
member of the Wider Tepnel Group or any such mortgage, charge or other security 
interest (whenever arising or having arisen) becoming enforceable; 
2.3.3    any such arrangement, agreement, lease, licence, permit or other 
instrument being, or becoming capable of being, terminated or adversely modified 
or affected or any onerous obligation or liability arising or any adverse action 
being taken thereunder; 
2.3.4    any assets or interests of any member of the Wider Tepnel Group being 
or falling to be disposed of or charged or any right arising under which any 
such asset or interest could be required to be disposed of or charged or could 
cease to be available to any member of the Wider Tepnel Group; 
2.3.5    the rights, liabilities, obligations or interests of any member of the 
Wider Tepnel Group in, or the business of any such member with, any person, firm 
or body (or any arrangement or arrangements relating to any such interest or 
business) being terminated, adversely modified or adversely affected; 
2.3.6    any such member of the Wider Tepnel Group ceasing to be able to carry 
on business under any name under which it presently does so; 
2.3.7    the value, financial or trading position, profits or prospects of 
Tepnel or any member of the Wider Tepnel Group being prejudiced or adversely 
affected; 
2.3.8the creation of any liability of any member of the Wider Tepnel Group to 
make severance, termination, bonus or other payment to any of its directors or 
officers; or 
2.3.9the creation of any liability (actual or contingent) by any member of the 
Wider Tepnel Group other than in the ordinary course of business, and no event 
having occurred which under any provision of any agreement, arrangement, 
licence, permit or other instrument to which any member of the Wider Tepnel 
Group is a party or by or to which any such member or any of its assets may be 
bound or subject, could reasonably be expected to result in any of the events or 
circumstances which are referred to in conditions 2.3.1. to 2.3.8; 
2.4save as fairly disclosed in the Annual Report or as Publicly Announced or 
fairly disclosed in writing to Gen-Probe or its advisers by or on behalf of 
Tepnel in the course of the negotiations relating to the Offer, in each case 
prior to the date of this announcement, no member of the Wider Tepnel Group 
having since 30 June 2008: 
2.4.1    issued or agreed to issue or authorised or proposed or announced its 
intention to authorise or propose the issue of additional shares of any class, 
or securities convertible into, or exchangeable for, or rights, warrants or 
options to subscribe for or acquire, any such shares or convertible securities 
(save as between Tepnel and wholly-owned subsidiaries of Tepnel and save for the 
issue of the Tepnel Shares pursuant to or in connection with rights granted 
before the date of this announcement under, or the grant of rights before such 
date under, Tepnel Share Schemes or instruments constituting Tepnel Share 
Warrants); 
2.4.2    recommended, declared, paid or made or proposed to recommend, declare, 
pay or make any bonus issue, dividend or other distribution whether payable in 
cash or otherwise other than dividends (or other distributions whether payable 
in cash or otherwise) lawfully paid or made by any wholly-owned subsidiary of 
Tepnel to Tepnel or any of its wholly-owned subsidiaries; 
2.4.3    other than pursuant to the implementation of the Offer (and save for 
transactions between Tepnel and its wholly-owned subsidiaries and transactions 
in the ordinary course of business) implemented, effected, authorised, proposed 
or announced its intention to implement, effect, authorise or propose any 
merger, demerger, reconstruction, amalgamation, scheme, commitment or 
acquisition or disposal of assets or shares (or the equivalent thereof) in any 
undertaking or undertakings, that is material in the context of the Wider Tepnel 
Group taken as a whole, its share or loan capital or in the context of the 
Offer; 
2.4.4    (save for transactions between Tepnel and its wholly-owned subsidiaries 
and save for transactions in the ordinary course of business) disposed of, or 
transferred, mortgaged or charged, or created any other security interest over, 
any asset or any right, title or interest in any asset that is material in the 
context of the Wider Tepnel Group taken as a whole or authorised, proposed or 
announced any intention to do so; 
2.4.5made, authorised, proposed or announced an intention to propose any change 
in its loan capital which is material in the context of the Wider Tepnel Group; 
2.4.6(save for transactions between Tepnel and its wholly-owned subsidiaries) 
issued, authorised or proposed or announced an intention to authorise or 
propose, the issue of any debentures or (save for transactions between Tepnel 
and its wholly-owned subsidiaries or transactions under existing credit 
arrangements or in the ordinary course of business) incurred any indebtedness or 
contingent liability which is material in the context of the Wider Tepnel Group 
as a whole or in the context of the Offer; 
2.4.7    entered into, varied or terminated, or authorised, proposed or 
announced its intention to enter into, terminate or vary any contract, 
arrangement, agreement, transaction or commitment (whether in respect of capital 
expenditure or otherwise) which is of a long term, unusual or onerous nature or 
magnitude or which involves or is reasonably likely to involve an obligation of 
such a nature or magnitude which is, in any such case, or which is or is likely 
to be restrictive on the business of any member of the Wider Tepnel Group, which 
is, in any such case, material in the context of the Wider Tepnel Group or in 
the context of the Offer; 
2.4.8    entered into or varied to a material extent or authorised, proposed or 
announced its intention to enter into or vary to a material extent the terms of, 
or make any offer (which remains open for acceptance) to enter into or vary to a 
material extent the terms of, any service agreement with any director or senior 
executive of any member of the Wider Tepnel Group; 
2.4.9    proposed, agreed to provide or modified the terms of any share option 
scheme, incentive scheme or other benefit relating to the employment or 
termination of employment of any person employed by the Wider Tepnel Group save 
as agreed by Gen-Probe in writing; 
2.4.10other than in connection with the Offer, implemented or effected, or 
authorised, proposed or announced its intention to implement or effect, any 
composition, assignment, reconstruction, amalgamation, commitment, scheme or 
other offer or arrangement otherwise than in the ordinary course of business; 
2.4.11purchased, redeemed or repaid or announced a proposal to purchase, redeem 
or repay any of its own shares or other securities (or the equivalent) or 
reduced or made any other change to or proposed the reduction or other change to 
any part of its share capital, save for any shares the allotment of shares in 
connection with the Tepnel Share Schemes or Tepnel Share Warrants pursuant to 
rights granted before the date of this announcement or as between Tepnel and 
wholly-owned subsidiaries of Tepnel; 
2.4.12(other than in respect of claims between Tepnel and wholly-owned 
subsidiaries of Tepnel) waived, compromised or settled any claim which is 
material in the context of the Wider Tepnel Group as a whole; 
2.4.13    terminated or varied the terms of any agreement or arrangement between 
any member of the Wider Tepnel Group and any other person in a manner which 
would or might reasonably be expected to have a material adverse effect on the 
financial position of the Wider Tepnel Group taken as a whole; 
2.4.14    (save as disclosed on publicly available registers prior to the date 
of the announcement or as envisaged in accordance with the terms of the 
Scheme) made any alteration to its memorandum or articles of association; 
2.4.15save to the extent agreed by Gen-Probe in writing, made or agreed or 
consented to any significant change to the terms of the trust deeds constituting 
the pension schemes established for its directors and/or employees and/or their 
dependants or any material favourable change to the benefits which accrue, or to 
the pensions which are payable (including contributions payable to any such 
Schemes), thereunder, or to the basis on which qualification for or accrual or 
entitlement to such benefits or pensions are calculated or determined or to the 
basis upon which the liabilities (including pensions) of such pension schemes 
are funded or made, or agreed or consented to any change to the trustees 
involving the appointment of a trust corporation; 
2.4.16    been unable, or admitted in writing that it is unable, to pay its 
debts or having stopped or suspended (or threatened to stop or suspend) payment 
of its debts generally or ceased or threatened to cease carrying on all or any 
part of any business compromised or settled any claim which is material in the 
context of the Wider Tepnel Group as a whole or in the context of the Offer; 
2.4.17    (other than in respect of a company which is dormant and was solvent 
at the relevant time) taken or proposed any corporate action or had any action 
or proceedings or other steps instituted against it for its winding-up 
(voluntary or otherwise), dissolution or reorganisation or for the appointment 
of a receiver, administrator, administrative receiver, trustee or similar 
officer of all or any material part of its assets or revenues or any analogous 
proceedings in any jurisdiction or appointed any analogous person in any 
jurisdiction; or 
2.4.18    entered into any contract, agreement, arrangement or commitment or 
passed any resolution or made any proposal or announcement with respect to, or 
to effect, any of the transactions, matters or events referred to in this 
condition 2.4; 
2.5    save as fairly disclosed in the Annual Report or as Publicly Announced or 
fairly disclosed in writing to Gen-Probe or its advisers by or on behalf of 
Tepnel in the course of negotiations relating to the Offer, in each case prior 
to the date of this announcement, since 30 June 2008 there having been: 
2.5.1    no adverse change or deterioration in the business, assets, financial 
or trading position or profits or prospects of any member of the Wider Tepnel 
Group which is material in the context of the Wider Tepnel Group taken as a 
whole or in the context of the Offer; 
2.5.2    no litigation, arbitration proceedings, prosecution or other legal 
proceedings having been threatened, announced or instituted by or against or 
remaining outstanding against or in respect of any member of the Wider Tepnel 
Group and which might reasonably be expected to have a material adverse effect 
on the Wider Tepnel Group taken as a whole or in the context of the Offer; 
2.5.3no enquiry or investigation by or complaint or reference to any Relevant 
Authority or other investigative body, threatened, announced, implemented or 
instituted or remaining outstanding by, against or in respect of any member of 
the Wider Tepnel Group which would or might reasonably be expected to have a 
material adverse effect on the Wider Tepnel Group taken as a whole in the 
context of the Offer; 
2.5.4no contingent or other liability having arisen or become apparent to any 
member of the Wider Gen-Probe Group which would or might reasonably be expected 
to adversely affect any member of the Wider Tepnel Group and which in any such 
case is material in the context of the Wider Tepnel Group taken as a whole or in 
the context of the Offer; and 
2.5.5    no steps taken and no omissions made which are likely to result in the 
withdrawal, cancellation, termination or modification of any licence held by any 
member of the Wider Tepnel Group which is necessary for the proper carrying on 
of its business, 
which is material in the context of the Wider Tepnel Group taken as a whole; 
2.6    save as fairly disclosed in the Annual Report or as Publicly Announced or 
fairly disclosed in writing to Gen-Probe or its advisers by or on behalf of 
Tepnel in the course of negotiations relating to the Offer, in each case prior 
to the date of this announcement, Gen-Probe not having discovered: 
2.6.1    that the financial, business or other information concerning the Wider 
Tepnel Group Publicly Announced or disclosed at any time by or on behalf of any 
member of the Wider Tepnel Group contains a misrepresentation of fact or omits 
to state a fact necessary to make the information contained therein not 
misleading and which was not subsequently corrected by 28 January 2009 by 
disclosure either publicly or otherwise to Gen-Probe, which is, in any case, 
material in the context of the Wider Tepnel Group or in the context of the 
Offer; 
2.6.2    that any member of the Wider Tepnel Group, partnership, company or 
other entity in which any member of the Wider Tepnel Group has a significant 
economic interest and which is not a subsidiary undertaking of the Wider Tepnel 
Group is, otherwise than in the ordinary course of business, subject to any 
liability, contingent or otherwise, which is material in the context of the 
Wider Tepnel Group taken as a whole or in the context of the Offer; 
2.6.3    any information which affects the import of any information disclosed 
at any time by or on behalf of any member of the Wider Tepnel Group to an extent 
which is material in the context of the Wider Tepnel Group as a whole or in the 
context of the Offer; 
2.6.4    that any past or present member of the Wider Tepnel Group has failed to 
comply in any material respect with any and/or all applicable legislation or 
regulations of any jurisdiction or any notice or requirement of any third party 
with regard to the storage, treatment, transport, handling, disposal, discharge, 
spillage, release, leak or emission of any waste or hazardous or harmful 
substance or any substance likely to impair the environment or harm human or 
animal health or otherwise relating to environmental matters or that there has 
otherwise been any such use storage, treatment, transport, handling, disposal, 
discharge, spillage, release, leak or emission (whether or not the same 
constituted non-compliance by any person with any such legislation or 
regulation, and whenever the same may have taken place), any of which 
non-compliance would be likely to give rise to any material liability (whether 
actual or contingent) or cost on the part of any member of the Wider Tepnel 
Group and which is material, in the aggregate, in the context of the Wider 
Tepnel Group taken as a whole; 
2.6.5    there is, or is reasonably likely to be, any material obligation or 
liability (whether actual or contingent) to make good, repair, reinstate or 
clean up any property now or previously owned, occupied, operated or made use of 
or controlled by any past or present member of the Wider Tepnel Group under any 
environmental legislation, regulation, notice, circular, order or other 
requirement of any Relevant Authority in any jurisdiction, in each case to an 
extent which is material in the context of the Wider Tepnel Group taken as a 
whole; or 
2.6.6    that any past or present member of the Wider Tepnel Group, partnership, 
company or entity in which any member of the Wider Tepnel Group has an economic 
interest and which is not a subsidiary undertaking of the Wider Tepnel Group, 
has breached any trade marks, service marks, trade names, domain names, logos, 
get-up, patents, inventions, registered and unregistered design rights, 
copyrights, semi-conductor topography rights, database rights and all other 
similar rights in any part of the world (including, where such rights are 
obtained or enhanced by registration, any registration of such rights and 
applications and rights to apply for such registrations) of any third party to 
an extent which is material in the context of the Wider Tepnel Group taken as a 
whole or in the context of the Offer. 
Part B: Waiver of conditions and further terms of the Offer 
Subject to the requirements of the Panel, Gen-Probe reserves the right to waive, 
in whole or in part, all or any of the above conditions 2.1 to 2.6 (inclusive). 
If Gen-Probe is required by the Panel to make an offer for Tepnel Shares under 
the provisions of Rule 9 of the City Code, Gen-Probe may make such alteration to 
any of the above conditions, including Condition 1, as are necessary to comply 
with the provisions of that Rule. 
Gen-Probe shall be under no obligation to waive (if capable of waiver), to 
determine to be or remain satisfied or to treat as fulfilled any of conditions 
2.1 to 2.6 (inclusive) by a date earlier than the latest date for the fulfilment 
of that condition notwithstanding that the other conditions of the Offer may at 
such earlier date have been waived or fulfilled and that there are at such 
earlier date no circumstances indicating that any of such conditions may not be 
capable of fulfilment. 
The Offer will lapse and the Scheme will not proceed unless all the above 
conditions have been fulfilled or, where permitted, waived or, where 
appropriate, have been determined by Gen-Probe to be or remain satisfied, by not 
later than four months from the date that the Scheme Document is posted or such 
later date (if any) as Tepnel and Gen-Probe may agree and (if required) the 
Court and the Panel may allow. 
Part C: Certain further terms of the Offer 
Gen-Probe reserves the right to elect to implement the Offer by way of a 
takeover offer. In such event, such offer will be implemented on the same terms 
(subject to appropriate amendments, including (without limitation) an acceptance 
condition set at ninety per cent. (or such less percentage, being more than 
fifty per cent., as Gen-Probe may decide) of the shares to which such offer 
relates), so far as applicable, as those which would apply to the Scheme. 
The availability of the Offer to persons not resident in the United Kingdom may 
be affected by the laws of the relevant jurisdictions. Persons who are not 
resident in the United Kingdom should inform themselves about and observe any 
applicable requirements. 
Tepnel Shares will be acquired under the Offer fully paid and free from all 
liens, equitable interests, charges, encumbrances and rights of pre-emption and 
any other rights and interests of any nature whatsoever and together with all 
rights now and hereafter attaching thereto including voting rights and the right 
to receive and retain in full all dividends and other distributions (if any) 
declared, made or paid on or after the date of this announcement. Any new Tepnel 
Shares issued to Gen-Probe or its nominee(s) pursuant to the Scheme will be 
issued on the same basis. 
The Scheme is governed by English law and will be subject to the jurisdiction of 
the English courts and the conditions set out above. 
  APPENDIX II 
SOURCES OF INFORMATION AND BASES OF CALCULATION 
 
 
(i)    The value placed by the Offer on the fully diluted share capital of 
Tepnel is based on 239,051,526 existing shares in issue, 32,371,000 share 
options outstanding and 71,167,915 share warrants outstanding representing, in 
aggregate, 342,590,441 fully diluted shares. 
(ii)    The closing share price on 21 January 2009 is the mid-market price taken 
from Bloomberg. 
(iii)    Unless otherwise stated, the financial information relating to Tepnel 
is extracted from the audited consolidated financial statements of Tepnel for 
the financial year to 31 December 2007, prepared in accordance with IFRS and 
from the unaudited consolidated financial statements of Tepnel (from its interim 
report) for the six months ended 30 June 2008, prepared in accordance with IFRS. 
(iv)Unless otherwise stated, the financial information relating to Gen-Probe is 
extracted from the audited consolidated financial statements of Gen-Probe (from 
its 10K filing) for the financial year to 31 December 2007, prepared in 
accordance with US GAAP and from the unaudited consolidated financial statements 
of Gen-Probe (from its 10Q filing) for the quarter ended 30 September 2008, 
prepared in accordance with US GAAP. 
(v)EPS accretion has been calculated on a non-GAAP basis, excluding 
acquisition-related charges and the expected increase in depreciation and 
amortization expense from acquired assets. EPS refers to earnings before 
acquisition accounting adjustments and has not been prepared in accordance with 
US GAAP. 
(vi)This announcement also contains certain financial measures that are not 
calculated in accordance with US GAAP, including pro forma EPS accretion and 
dilution expectations, as stated above. Gen-Probe's management believes that 
these US non-GAAP financial measures provide Gen-Probe investors meaningful 
supplemental information regarding the expected financial results of the 
acquisition. 
 (vii)    All US dollar figures have been converted to pounds sterling at the 
rate of GBP1 = US$1.424 being the exchange rate at 5:00p.m. in London on 29 
January 2009, as sourced from Bloomberg. 
(viii)    The International Securities Identification Number for Tepnel Shares 
is GB0008841859. 
  APPENDIX III 
DETAILS OF IRREVOCABLE UNDERTAKINGS 
 
 
The following holders of Tepnel Shares have given irrevocable undertakings to 
vote in favour of the Offer: 
Directors 
+--------------+--------------+--------------+--+--------------+-----------+ 
| Name         | Number of    | % of issued  |  | Number of    | % of      | 
|              | Tepnel       | share        |  | Tepnel       | fully     | 
|              | Shares       | capital      |  | Shares       | diluted   | 
|              |              |              |  | arising on   | share     | 
|              |              |              |  | exercise of  | capital   | 
|              |              |              |  | Tepnel Share |           | 
|              |              |              |  | Warrants(1)  |           | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| IA Craig     | 2,000,000    | 0.84%        |  | 350,000      | 0.69%     | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| B            | 5,956,783    | 2.49%        |  | 4,910,000    | 3.17%     | 
| Matzilevich  |              |              |  |              |           | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| MK Slater    | 100,000      | 0.04%        |  | -            | 0.03%     | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| DR Marvin    | 18,000       | 0.01%        |  | 1,593,326    | 0.47%     | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| M Miller     | -            | -            |  | -            | -         | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| AJM Clarke   | 1,161,000    | 0.49%        |  | 1,061,000    | 0.65%     | 
| PhD          |              |              |  |              |           | 
+--------------+--------------+--------------+--+--------------+-----------+ 
| Total        | 9,235,783    | 3.86%        |  | 7,914,326    | 5.01%     | 
+--------------+--------------+--------------+--+--------------+-----------+ 
These undertakings will remain binding in the event of a higher competing offer 
being made for Tepnel, unless the Offer lapses or is withdrawn. 
Certain Institutional Shareholders 
+-----------------+--------------+--------------+--+--------------+-----------+ 
| Name            | Number of    | % of issued  |  | Number of    | % of      | 
|                 | Tepnel       | share        |  | Tepnel       | fully     | 
|                 | Shares       | capital      |  | Shares       | diluted   | 
|                 |              |              |  | arising on   | share     | 
|                 |              |              |  | exercise of  | capital   | 
|                 |              |              |  | Tepnel Share |           | 
|                 |              |              |  | Warrants(1)  |           | 
+-----------------+--------------+--------------+--+--------------+-----------+ 
| Ignis           | 8,953,419    | 3.75%        |  | -            | 2.61%     | 
| Investment      |              |              |  |              |           | 
| Services Ltd    |              |              |  |              |           | 
+-----------------+--------------+--------------+--+--------------+-----------+ 
| Gartmore        | 22,673,355   | 9.48%        |  | -            | 6.62%     | 
| Investment      |              |              |  |              |           | 
| Limited         |              |              |  |              |           | 
+-----------------+--------------+--------------+--+--------------+-----------+ 
| Orbimed         | 47,000,000   | 19.66%       |  | 45,840,000   | 27.10%    | 
| Capital LLC     |              |              |  |              |           | 
+-----------------+--------------+--------------+--+--------------+-----------+ 
| AXA-Framlington | 8,115,943    | 3.40%        |  | 110,725      | 2.40%     | 
| Investment      |              |              |  |              |           | 
| Management      |              |              |  |              |           | 
| Limited         |              |              |  |              |           | 
+-----------------+--------------+--------------+--+--------------+-----------+ 
| Total           | 86,742,717   | 36.29%       |  | 45,950,725   | 38.73%    | 
+-----------------+--------------+--------------+--+--------------+-----------+ 
(1) The terms of these irrevocables require the relevant Tepnel Share Warrants 
to be exercised conditional upon the Court Sanctioning the Scheme. 
These undertakings cease to be binding if: (i) the Scheme Document is not posted 
by 27 February 2009 (or such later date as the Panel may agree); (ii) the Offer 
lapses or does not become effective, lapses or is withdrawn in accordance with 
its terms; or (iii) upon the announcement of a competing offer at a price of at 
least 10 per cent. above the value of the Offer in the case of Orbimed Capital 
LLC and AXA-Framlington Investment Management Limited and 15 per cent. above the 
value of the Offer in the case of Ignis Investment Services Ltd and Gartmore 
Investment Limited. 
 
 
  APPENDIX IV 
IMPLEMENTATION AGREEMENT 
 
 
The Implementation Agreement includes the following provisions: 
 
 
Inducement fee 
 
 
Tepnel has agreed to pay an inducement fee to Gen-Probe of GBP928,420 being one 
per cent. of the value of the aggregate consideration being offered for the 
Tepnel Shares by Gen-Probe under the Scheme, if: 
 
 
(i)The Scheme Document, which sets out the terms of the Offer, is not posted by 
Tepnel to the Tepnel Shareholders within 28 days of the date of this 
Announcement (unless solely due to the default of Gen-Probe or its advisers); 
 
 
(ii)The Tepnel Directors, for whatever reason, withdraw, adversely modify or 
qualify their recommendation to Tepnel Shareholders to vote in favour of the 
Scheme and/or the resolutions at the GM and the Scheme does not complete, 
provided that the recommendation ceasing to be unanimous shall not constitute an 
adverse modification or qualification; or 
 
 
(iii)An independent competing offer is announced prior to the Offer lapsing or 
being withdrawn and that independent competing offer is either: (i) recommended 
by the Tepnel Directors; or (ii) is declared unconditional in all respects or is 
completed. 
 
 
Non-solicitation 
 
 
Tepnel has undertaken that it will not, and will procure that no member of its 
Group nor any director, employee, adviser or agent of them will, directly or 
indirectly solicit, invite or encourage any enquiries, negotiations or 
discussions directly or indirectly with a view to obtaining an independent 
competing offer. 
 
 
If any third party makes an independent competing offer, Tepnel undertakes that 
it will not, and will procure that no member of its Group nor any director, 
employee, adviser or agent of Tepnel or any member of its Group will, directly 
or indirectly engage with that third party or enter into any discussions or 
negotiations with that third party in relation to such independent competing 
offer. 
 
 
Furthermore, Tepnel has agreed to notify Gen-Probe promptly, and in any event 
within 72 hours, of it becoming aware: 
 
 
(i)of any approach that is made to Tepnel or to any member of its Group (or any 
director, officer, adviser or agent of Tepnel or any member of its Group) 
regarding any independent competing offer and will inform Gen-Probe of the 
material terms of such approach and keep Gen-Probe informed of any material 
changes to the terms of such approach; or 
 
 
(ii)if any information is provided to a third party in connection with an 
independent competing offer. 
 
 
Tepnel has also agreed that it will not, and will procure that each member of 
its Group and its directors, officers and agents will not, provide any due 
diligence information to any person other than as required under Rule 20.2 of 
the Code. 
 
 
 
 
 
 
Matching Rights 
 
 
Tepnel has agreed that Gen-Probe has the right to match any competing offer of a 
third party. Provided that Gen-Probe matches any competing offer, the Tepnel 
Directors have agreed to recommend such revised offer to the Shareholders. 
 
 
Alternative means of implementing the Offer 
 
 
Gen-Probe may elect to implement the Offer as an offer provided that the offer 
is made in accordance with the terms and conditions set out in this Announcement 
and, in the opinion of Seymour Pierce, the consideration is equal to or greater 
than the consideration specified in this Announcement. 
 
 
Termination 
 
 
The Implementation Agreement will terminate with immediate effect (other than 
the provisions relating to the inducement fee) on the occurrence of the earliest 
of the following: 
 
 
(i)    if a condition of the Offer is incapable of satisfaction 
 
 
(ii)if (i) the Scheme is not sanctioned by the Tepnel Shareholders at the Court 
Meeting; the resolutions are not passed at the GM; or (iii) the Court refuses to 
grant either of the Court Orders, in each case unless Gen-Probe has within 5 
Business Days of such event elected to implement the Offer by way of an offer; 
or 
 
 
(iii)by notice in writing from Gen-Probe to Tepnel if the Tepnel Directors have 
withdrawn or adversely modified or qualified their recommendation (or intention 
to recommend) to Tepnel Shareholders to vote in favour of the Scheme and the GM 
Resolutions (or if applicable to accept an offer) and either (i) the Panel 
consents to Gen-Probe withdrawing its Offer (while structured as a Scheme) or 
(ii) an independent competing offer becomes or is declared wholly unconditional 
or is completed; or 
 
 
(iv)if Gen-Probe elects to implement the Offer by way of an offer, if the Offer 
is not announced under Rule 2.5 of the Code within 10 Business Days of the 
election or once announced, the Offer lapses in accordance with its terms or is 
withdrawn; or 
 
 
(v)if the Effective Date has not occurred within four months of the posting of 
the Scheme Document; or 
 
 
(vi)with the express written consent of Gen-Probe and Tepnel at any time prior 
to the Effective Date. 
  APPENDIX V 
DEFINITIONS 
 
 
The following definitions apply throughout this announcement unless the context 
requires otherwise. 
 
+----------------------------+---------------------------------------------+----------+ 
| "AIM"                      | the AIM market operated by the London Stock Exchange   | 
+----------------------------+--------------------------------------------------------+ 
| "Annual Report"            | the annual report and accounts of Tepnel for the year  | 
|                            | ended 31 December 2007                                 | 
+----------------------------+--------------------------------------------------------+ 
| "Business Day"             | a day (other than Saturdays, Sundays and public        | 
|                            | holidays in the UK) on which banks are open for        | 
|                            | business (other than solely for trading and settlement | 
|                            | in Euros) in the City of London                        | 
+----------------------------+--------------------------------------------------------+ 
| "Capital Reduction"        | the reduction of Tepnel's share capital provided for   | 
|                            | by the Scheme                                          | 
+----------------------------+--------------------------------------------------------+ 
| "City Code" or "Code"      | the City Code on Takeovers and Mergers                 | 
+----------------------------+--------------------------------------------------------+ 
| "Court"                    | the High Court of Justice in England and Wales         | 
+----------------------------+--------------------------------------------------------+ 
| "Court Meeting(s)"         | the meeting of Tepnel Shareholders to be convened      | 
|                            | pursuant to an order of the Court under the Companies  | 
|                            | Act 2006 for the purpose of considering and if thought | 
|                            | fit approving the Scheme (with or without              | 
|                            | modification) and any adjournment thereof              | 
+----------------------------+--------------------------------------------------------+ 
| "Court Order(s)"           | the order of the Court sanctioning the Scheme under    | 
|                            | the Companies Act 2006 and the order of the Court      | 
|                            | confirming the Capital Reduction under the Companies   | 
|                            | Act 1985 respectively or, where the context requires,  | 
|                            | either of them                                         | 
+----------------------------+--------------------------------------------------------+ 
| "CREST"                    | the system for paperless settlement of trades in       | 
|                            | securities operated by CREST Co Limited in accordance  | 
|                            | with the Uncertificated Securities Regulations 2001    | 
|                            | (SI 2001 No 3755)                                      | 
+----------------------------+--------------------------------------------------------+ 
| "Effective Date"           | the date on which the Scheme becomes effective         | 
|                            | pursuant to its terms or, should Gen-Probe elect to    | 
|                            | implement the Offer by way of an offer, the date on    | 
|                            | which the Offer becomes or is declared unconditional   | 
|                            | in all respects                                        | 
+----------------------------+--------------------------------------------------------+ 
| "Exchange Act"             | the United States Securities Exchange Act of 1934 (as  | 
|                            | amended) and the rules and regulations promulgated     | 
|                            | thereunder                                             | 
+----------------------------+--------------------------------------------------------+ 
| "Forms of Proxy"           | the forms of proxy for use at the Court Meeting and    | 
|                            | the General Meeting                                    | 
+----------------------------+--------------------------------------------------------+ 
| "FSA" or "Financial        | the Financial Services Authority in its capacity as    | 
| Services Authority"        | the competent authority for the purposes of Part VI of | 
|                            | the Financial Services and Markets Act 2000            | 
+----------------------------+--------------------------------------------------------+ 
| "General Meeting" or "GM"  | the general meeting of Tepnel Shareholders (and any    | 
|                            | adjournment thereof) to be convened in connection with | 
|                            | the Offer                                              | 
+----------------------------+--------------------------------------------------------+ 
| "Gen-Probe"                | Gen-Probe Incorporated, a company incorporated in      | 
|                            | Delaware with commission file number 001-31279, having | 
|                            | its registered office at 10210 Genetic Center Drive,   | 
|                            | San Diego, CA                                          | 
+----------------------------+--------------------------------------------------------+ 
| "Gen-Probe Directors"      | means the directors of Gen-Probe as at the date of     | 
|                            | this announcement                                      | 
+----------------------------+--------------------------------------------------------+ 
| "IFRS"                     | International Financial Reporting Standards            | 
+----------------------------+--------------------------------------------------------+ 
| "Implementation Agreement" | the implementation agreement dated on or about the     | 
|                            | date of this announcement between Tepnel and Gen-Probe | 
|                            | pursuant to which, amongst other things, the parties   | 
|                            | have agreed to implement the Scheme                    | 
+----------------------------+--------------------------------------------------------+ 
| "Irrevocable Undertakings" | the irrevocable undertakings of the Tepnel Directors   | 
|                            | and certain institutional shareholders to vote in      | 
|                            | favour of the Scheme as set out in Appendix III to     | 
|                            | this announcement                                      | 
+----------------------------+--------------------------------------------------------+ 
| "London Stock Exchange"    | the London Stock Exchange plc               |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Merrill Lynch"            | Merrill Lynch International, of Merrill     |          | 
|                            | Lynch Financial Centre, 2 King Edward       |          | 
|                            | Street, London, EC1A 1HQ                    |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Offer"                    | the proposed recommended offer of 27.1      |          | 
|                            | pence in cash per Tepnel Share to be made   |          | 
|                            | by Gen-Probe to acquire the entire issued   |          | 
|                            | and to be issued ordinary share capital of  |          | 
|                            | Tepnel by means of the Scheme or, should it |          | 
|                            | so elect, by means of an offer              |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Offer Price"              | 27.1 pence in cash per Tepnel Share         |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Panel"                    | The Panel on Takeovers and Mergers          |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Publicly Announced"       | means fairly disclosed in any public        |          | 
|                            | announcement by Tepnel to any regulatory    |          | 
|                            | information service or in its report and    |          | 
|                            | accounts for the year ended 31 December     |          | 
|                            | 2007                                        |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Registrar"                | the Registrar of Companies in England and   |          | 
|                            | Wales                                       |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Regulatory Information    | a service approved by the London Stock      |          | 
| Service"                   | Exchange for the distribution to the public |          | 
|                            | of AIM announcements and included within    |          | 
|                            | the list maintained on the London Stock     |          | 
|                            | Exchange's website,                         |          | 
|                            | www.londonstockexchange.com                 |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Restricted Jurisdiction"  | any jurisdiction where extension or         |          | 
|                            | acceptance of the Offer would violate the   |          | 
|                            | law of that jurisdiction                    |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Scheme"                   | the scheme of arrangement under the         |          | 
|                            | Companies Act 2006 to be proposed by Tepnel |          | 
|                            | to the Scheme Shareholders (with or without |          | 
|                            | modification on terms agreed by Tepnel and  |          | 
|                            | Gen-Probe), the full terms of which will be |          | 
|                            | set out in the Scheme Document              |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Scheme Document"          | the document to be sent to the Tepnel       |          | 
|                            | Shareholders, containing and setting out    |          | 
|                            | the Scheme and the notices convening the    |          | 
|                            | Court Meetings and the General Meeting      |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Scheme Record Time"       | 6.00 p.m. on the business day immediately   |          | 
|                            | prior to the Effective Date                 |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Scheme Shareholders"      | holders of Scheme Shares                    |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Scheme Shares"            | (i)         the Tepnel Shares in issue at   |          | 
|                            | the date of the Scheme;                     |          | 
+----------------------------+---------------------------------------------+----------+ 
|                            | (ii)        any Tepnel Shares issued after  |          | 
|                            | the date of the Scheme Document and before  |          | 
|                            | the Voting Record Time; and                 |          | 
+----------------------------+---------------------------------------------+----------+ 
|                            | (iii)       any Tepnel Shares issued at or  |          | 
|                            | after the Voting Record Time and before the |          | 
|                            | Scheme Record Time in respect of which the  |          | 
|                            | original or any subsequent holders thereof  |          | 
|                            | are, or shall have agreed in writing to be, |          | 
|                            | bound by the Scheme,                        |          | 
+----------------------------+---------------------------------------------+----------+ 
|                            | in each case excluding any Tepnel Shares    |          | 
|                            | registered in the name of or beneficially   |          | 
|                            | owned by members of the Wider Gen-Probe     |          | 
|                            | Group                                       |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Securities Act"           | The United States Securities Act of 1933    |          | 
|                            | (as amended) and the rules and regulations  |          | 
|                            | promulgated thereunder                      |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Seymour Pierce"           | Seymour Pierce Limited, of 20 Old Bailey,   |          | 
|                            | London EC4M 7EN                             |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel"or the "Company"   | Tepnel Life Sciences plc, a company         |          | 
|                            | incorporated in England and Wales with      |          | 
|                            | registration number 2722343 having its      |          | 
|                            | registered office at Heron House, Oaks      |          | 
|                            | Business Park, Crewe Road, Wythenshawe,     |          | 
|                            | Manchester M23 9HZ                          |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Directors"         | the directors of Tepnel as at the date of   |          | 
|                            | this announcement                           |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Group"             | Tepnel, its subsidiaries and subsidiary     |          | 
|                            | undertakings                                |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Securities"        | securities convertible or exchangeable into |          | 
|                            | Tepnel Shares                               |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Shareholders" or   | the holders of Tepnel Shares                |          | 
| "Shareholders"             |                                             |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Shares"            | the existing unconditionally allotted or    |          | 
|                            | issued and fully paid ordinary shares of 1  |          | 
|                            | pence each in the capital of Tepnel         |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Share Schemes"     | the Tepnel Executive Share Option Scheme,   |          | 
|                            | the Tepnel Unapproved Share Scheme, the     |          | 
|                            | Tepnel 2006 Long Term Incentive Plan and    |          | 
|                            | the Tepnel Enterprise Management Incentive  |          | 
|                            | Scheme                                      |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Tepnel Share Warrants"    | the warrants issued under the Warrant       |          | 
|                            | Instruments dated 1 November 2004, 31 May   |          | 
|                            | 2006 and 15 December 2006                   |          | 
+----------------------------+---------------------------------------------+----------+ 
| "UKLA"                     | the UK Listing Authority, being the         |          | 
|                            | Financial Services Authority Limited acting |          | 
|                            | in its capacity as the competent authority  |          | 
|                            | for the purposes of Part IV of the          |          | 
|                            | Financial Services and Markets Act 2000     |          | 
+----------------------------+---------------------------------------------+----------+ 
| "United Kingdom" or "UK"   | the United Kingdom of Great Britain and     |          | 
|                            | Northern Ireland                            |          | 
+----------------------------+---------------------------------------------+----------+ 
| "United States" or "US"    | the United States of America, its           |          | 
|                            | territories and possessions, any State of   |          | 
|                            | the United States of America and the        |          | 
|                            | District of Columbia                        |          | 
+----------------------------+---------------------------------------------+----------+ 
| "US dollar" or "US$"       | the lawful currency of the United States    |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Voting Record Time"       | 6.00 p.m. on the day which is two days      |          | 
|                            | before the date of the Court Meeting or, if |          | 
|                            | such Court Meeting is adjourned, 6.00 p.m.  |          | 
|                            | on the day which is two days before the day |          | 
|                            | of such adjourned meeting                   |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Wider Gen-Probe Group"    | Gen-Probe, its subsidiaries, subsidiary     |          | 
|                            | undertakings and associated undertakings    |          | 
|                            | and any other body corporate, partnership,  |          | 
|                            | joint venture or person in which Gen-Probe  |          | 
|                            | and such undertakings (aggregating their    |          | 
|                            | interests) have a direct or indirect        |          | 
|                            | interest of 20 per cent. or more of the     |          | 
|                            | voting or equity capital or equivalent      |          | 
+----------------------------+---------------------------------------------+----------+ 
| "Wider Tepnel Group"       | Tepnel, its subsidiaries, subsidiary        |          | 
|                            | undertakings and associated undertakings    |          | 
|                            | and any other body corporate, partnership,  |          | 
|                            | joint venture or person in which Tepnel and |          | 
|                            | such undertakings (aggregating their        |          | 
|                            | interests) have a direct or indirect        |          | 
|                            | interest of 20 per cent. or more of the     |          | 
|                            | voting or equity capital or the equivalent  |          | 
+----------------------------+---------------------------------------------+----------+ 
 
 
For the purposes of this announcement, "subsidiary", "subsidiary undertaking", 
"undertaking" and "associated undertaking" have the respective meanings given 
thereto by the Companies Act 1985, but for this purpose ignoring paragraph 
20(1)(b) of Schedule 4A of the Companies Act 1985. 
All the times referred to in this announcement are London times unless otherwise 
stated. 
References to the singular include the plural and vice versa. 
GBP and pence (or penny) means pounds and pence sterling, the lawful currency of 
the United Kingdom. 
 
 
 
This information is provided by RNS 
            The company news service from the London Stock Exchange 
   END 
 
 OFFURONRKWRAORR 
 

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