RNS Number:7147Q
Tepnel Life Sciences PLC
25 March 2008



                              TEPNEL LIFE SCIENCES

                               Holding in Company


TR-1 Notification of a Major Interest in Shares

1. Identity of the                
issuer or the underlying
issuer of existing
shares to which voting
rights are attached            Tepnel Life Sciences

2. Reason for Notification
An acquisition or disposal of voting rights                      X
An acquisition or disposal of financial instruments which may result in the
aquisition of shares already issued to which voting rights are attached.
An event changing the breakdown of voting rights

3. Full name of person(s) subject to the       AXA S.A, 25 Avenue Matignon, 75008
notification obligation                        Paris and its group of companies

4. Full name of shareholder(s) if different from 3.

5.Date of the transaction and date in which                   19/03/2008
thresshold is crossed or breached

6.Date on which isser notified                                20/03/2008

7. Threshold(s) that is/are crossed or reached:                    12%

8. Notified details:

A: Voting rights attached to shares

Class or     Situation Previous to    Resulting situation after the triggering
Type of      the triggering           transaction
shares       transaction

Number of    Number of    Number of  Number of voting     % of voting rights
shares       voting       shares     rights
rights       Direct       Direct     Direct    Indirect   Direct    Indirect
27,732,428   27,732,428      0          0     26,859,073   0.00     11.67

0884185

B: Financial Instruments

Resulting situation after triggering transaction

Type of      Expiration  Exercise /   Number of voting rights that may be       % of
Financial    date        conversion   acquired if the instrument is exercised / voting
Instrument               period /     converted                                 rights
date

1090161      26/11/2009   Anytime to                  8,840,000                   3.84
                          26/11/2009
1090194      26/11/2011   Anytime to                  1,774,395                   0.77
                          26/11/2011

Total A + B

Number of Voting Rights                        % of voting rights
37,473,468                                     16.27


Proxy Voting

10. Name of proxy holder:

11. Number of Voting rights Proxy Holder will
cease to hold:

12. Date on which proxy holder will cease to
hold voting rights:

13.Additional
Information:

14. Contact Name         Terry Marsh

15. Contact telephone    020 7003 2637
    number

Annex to Notification of Major Interests in shares

Identification of the person or legal entity subject to the notification obligation

Full name                  AXA S.A and its group of companies
Contact Address            25 Avenue Matignon, 75008 Paris
Phone Number

Other Useful information

Identity of the notifier, if applicable

Full name                  Terry Marsh
Contact Address            7 Newgate Street, London EC1A 7NX, UK
Phone Number               020 7003 2637
Other Useful information   AXA IM UK is a 100% direct subsiduary of AXA IM
                           S.A., which is in turn indirectly wholly owned by
                           AXA S.A.

Additional Information





                      This information is provided by RNS
            The company news service from the London Stock Exchange

END
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