RNS Number:5762K
Tepnel Life Sciences PLC
25 September 2001



TEPNEL LIFE SCIENCES PLC ('the Company')

25th September 2001



HOLDING IN COMPANY

The Company received notification on 24 September 2001 that LeggMason
Investors Asset Managers hold 3,009,243 ordinary shares of 1p each in the
Company ('Shares') representing 3.21% of the company's issued ordinary share
capital.

LeggMason Investors Aim Distribution Trust plc: 2,006,162 Shares

LeggMason Investors Venture Capital Trust plc: 1,003,081 Shares



These shares are registered in the name of HSBC Global Custody Nominees (UK)
Ltd.



END
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