RNS Number:4358K
Tepnel Life Sciences PLC
21 September 2001


TEPNEL LIFE SCIENCES PLC ("the Company")

21 September 2001

HOLDING IN COMPANY

The Company was informed on 21 September 2001 by Close Asset Management
Holdings Limited that Close Brothers Group PLC ("Close Bros.") has a total
holding of 9,858,410 ordinary 1p shares in the Company ("Shares") representing
10.49% of the Company's issued ordinary share capital.

Close Technology & General VCT PLC 1,639,450 Shares (1.74%)

Close Brothers Protected VCT PLC 964,382 Shares (1.03%)

Close Brothers AIM VCT PLC 2,865,107 Shares (3.05%)

Close Beacon Investment Fund 3,364,336 Shares (3.58%)

Close Finsbury Global Investment Funds PLC

- Universal Life Sciences Fund 1,025,135 Shares (1.09%)

 The above interests are non-beneficial to Close Bros. and arise by virtue of
the discretionary management of the above shares under written agreements
between the beneficial owners of the shares as listed above and Close Finsbury
Asset Management Limited, Close Bothers Investment Limited, Close Investment
Limited and Reabourne Technology Investment Management Limited, which are all
subsidiaries of Close Bros.

END



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