RNS Number:7403I
Tepnel Life Sciences PLC
20 August 2001

TEPNEL LIFE SCIENCES PLC ("the Company")

20 August 2001

HOLDING IN COMPANY

The Company was informed on 17 August 2001 by Framlington Investment
Management Limited that their interest as investment managers is 11,555,029
ordinary 1p shares in the Company, representing 12.34% of the Company's issued
ordinary shares capital.

These shares are registered as follows:

HSBC Nominees Limited a/c 811664      11,087,602 shares

HSBC Nominees Limited a/c 896177      467,427 shares

END
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