RNS Number:7700H
Tepnel Life Sciences PLC
31 July 2001


TEPNEL LIFE SCIENCES PLC ("the Company")

31 July 2001

HOLDING IN COMPANY

The Company was informed on 29 July 2001 by Close Asset Management Holdings
Limited that Close Brothers Group PLC ("Close Bros.") has a total holding of
5,654,302 ordinary 1p shares in the Company ("Shares") representing 6.03% of
the Company's issued ordinary share capital.

Close Technology & General VCT PLC           1,639,750 Shares (1.75%)

Close Brothers Protected VCT PLC               964,382 Shares (1.03%)

Close Brothers AIM VCT PLC                     870,635 Shares (0.87%)

Close Beacon Investment Fund                 1,204,400 Shares (1.29%)

Close Finsbury Global Investment Funds PLC

- Universal Life Sciences Fund               1,025,135 Shares (1.09%)


The above interests are non-beneficial to Close Bros. and arise by virtue of
the discretionary management of the above shares under written agreements
between the beneficial owners of the shares as listed above and Close Finsbury
Asset Management Limited, Close Bothers Investment Limited, Close Investment
Limited and Reabourne Technology Investment Management Limited, which are all
subsidiaries of Close Bros.

END



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