31st March 2005

               TEPNEL LIFE SCIENCES PLC ("the Company", AIM:TED)               

                                www.tepnel.com                                 

      Tepnel's preliminary results for the year ended 31st December 2004       

   Tepnel Life Sciences provides research products and services to the fast    
    growing pharmaceutical and biotechnology markets and provides molecular    
                       diagnostic products and services                        

Highlights

  * Completion of Tepnel Lifecodes acquisition at a favourable price
   
  * Increase in annual sales from �3.9 million (2003) to �10.2 million (2004)
   
  * Reduction in annual operating losses (pre-exceptional items) from �2.17
    million (2003) to �1.73 million
   
  * Secured new equity funding of �4.2 million (before expenses)
   
  * Completion of Diaclone acquisition
   
Chairman's Statement

2004 was a year of significant change and growth for Tepnel, with the
completion of two international acquisitions, Tepnel Lifecodes Corporation
(formerly Orchid Diagnostics) in January and Diaclone Research SAS in December.
These marked the Group's entrance into the strategically important markets of
molecular diagnostics and monoclonal antibody development and production.

The acquisition of Tepnel Lifecodes based in Stamford, Connecticut USA, was
completed in January 2004 for an initial consideration of $3.45m. Following a
review of the completion accounts, the consideration was revised downwards to
$2.49m. We are pleased to report that this important new addition to our Group
performed in line with management's expectations for the year under review. A
rapid integration of the business has allowed us to commence the sale and
distribution of our existing Tepnel DNA purification products and Tepnel
Biosystems food safety tests into continental USA.

Tepnel's second acquisition in 2004 was Diaclone Research SAS in December for a
consideration of Euro2.37 million. The company, located in Besancon, France,
produces monoclonal antibodies for in vitro studies and diagnostic purposes.
Diaclone has strong historical relationships with several major pharmaceutical
companies and this is expected to create cross-selling opportunities for both
our TSS Division and for Diaclone to build incremental revenues in the future.

Tepnel also secured significant new funding in 2004. A successful round of �
4.2m (before expenses) in November was used to raise the funds required for the
acquisition of Diaclone Research SAS. In addition the funds will be used for
the construction of a biopharmaceutical facility for the Tepnel Scientific
Services business in Livingston, Scotland. The Company also issued 74.4 million
warrants to subscribe for shares at 6.98 pence per share and raised �0.6
million of equity funding at the beginning of the year through Cornell Capital
Partners Offshore L.P.

Poor progress in sales of our Nucleoplex and Nucleopure systems during the year
was a major disappointment. The Board has decided that these products would
have a better chance of success with a specialist instrument business and we
are actively searching for appropriate opportunities to sell the instruments
operation to such a company. Alternatively we may choose a partner through whom
we would retain the right to sell reagents to end-users. The Group has since
the year-end ceased the research, development, sales and marketing activities
associated with these two projects and the benefits of this decision are
expected to contribute positively to our financial results in 2005.

Financial results

Turnover for the twelve months ended 31st December 2004 reached �10.2 million
from �5.7 million in the 18 months to 31st December 2003. Turnover in the
calendar year 2004 from activities owned in 2003, grew 4.5% to �4.04 million
(2003 - �3.87 million). Turnover from acquisitions in the year contributed �
6.15 million (2003: � nil)

Operating losses for the twelve months were �2.28 million (2003 18 months: �
5.94 million) after taking account of exceptional items totalling �0.55 million
(2003 18 months: �2.35 million). An exceptional loss was recognised in the
following area during the final six months of the year:

  * The lack of progress in sales of the Nucleoplex and Nucleopure instruments
    systems has resulted in cessation of continued research, development, sales
    and marketing activities associated with these products. The Company has
    provided at year-end a total of �547,000, comprising �506,000 for
    write-down of stocks of these two instruments systems and �41,000 for
    redundancy costs for people employed directly or indirectly on these
    projects.
   
Operating losses pre-exceptional items in calendar year 2004, from activities
owned in 2003, were �1.64 million, a reduction of 24.3% from the calendar year
2003 loss of �2.17 million. Acquisitions during the year made an operating loss
of �0.09 million (2003: �nil)

The basic loss per share for the year was 1.5 pence (2003 18 months: 5.6
pence).

Following the completion of the acquisition of Diaclone Research, cash balances
at 31st December 2004 amounted to �2.54 million. Net assets at year-end
totalled � 7.56 million (2003: � 5.90 million)

Overall, during the last year for Tepnel has once again demonstrated increased
sales and increased gross profits. In addition, losses before interest, tax and
exceptional items were reduced.

Board additions

Dr. Andrew Clark joined the Company as Non-Executive Director in May and brings
a wealth of experience to the Company. Andrew acts as a consultant for
Reabourne Technology Investment Management Ltd, which he co-founded in 1995.
Prior to this role he held several positions including UK and European
Biotechnology Analyst at Barings.

Post balance-sheet events

Our new subsidiary in France began the year well by securing a valuable
comprehensive research collaboration with Boehringer Ingelheim of Germany to
develop antibodies for research and possibly for therapeutic use. Under the
terms of the agreement Diaclone will generate murine monoclonal antibodies that
recognise human immune regulatory cells. The terms of the collaboration also
allow Tepnel to market for research and diagnostic applications those
monoclonal antibodies generated by Diaclone which are not developed for
therapeutic indications by Boehringer Ingelheim.

Future Prospects

Following the acquisition of Diaclone Research SAS in December 2004, our
businesses have been restructured into two divisions:

  * Research Products and Services; and
   
  * Molecular Diagnostics.
   
The Molecular Diagnostics division comprises the Tepnel Lifecodes and Tepnel
Diagnostics businesses acquired from Orchid Biosciences in January 2004,
whereas the Research Products and Services division comprises all our other
activities including the newly acquired Diaclone Research SAS.

These two divisions and their related markets we believe offer excellent growth
prospects. Resources for organic growth and further strategic M&A will be
directed towards these markets.

All of our UK companies, with the exception of Tepnel Life Sciences plc, traded
profitably during 2004. Certain ongoing annual payroll costs estimated to be
around �250,000 associated with the instrument side of Tepnel Life Sciences plc
have now been eliminated. This is expected to have a positive impact on
financial results for the year ended 31st December 2005.

Acquisitions during the year, whilst loss-making, are expected to achieve
operating profitability in 2005.

The key objective for the Tepnel Group is to reach sustainable profitability at
the earliest opportunity. Both of the new divisions and their constituent parts
are committed to further improvements in financial performance in 2005.

Current Trading

Tepnel has made a solid start to the year. The Board is confident of reporting
further progress towards profitability in 2005.

Alec Craig
Non-Executive Chairman
31st March 2005

References to the figures for the calendar year ended 31 December 2003 are
contained within note 6.


Consolidated Profit & Loss account for the year ended 31 December 2004


                                                  Unaudited              Audited
                                                                                
                                     Continuing Activities       Consolidated    
                                                                                
                                     Acquisitions           Year ended 18 Months
                                                                    31     ended
                                                              December        31
                                                                  2004  December
                                                                            2003
                             Notes                                              
                                                                                
                                            �'000     �'000      �'000     �'000
                                                                                
Turnover                       1            6,149     4,044     10,193     5,676
                                                                                
Cost of sales                             (3,687)   (1,780)    (5,467)   (3,041)
                                                                                
Gross profit                                2,462     2,264      4,726     2,635
                                                                                
Other administrative                        (443)   (2,279)    (2,722)   (3,320)
expenses                                                                        
                                                                                
Exceptional items              2                -     (547)      (547)   (2,348)
                                                                                
Total administrative                        (443)   (2,826)    (3,269)   (5,668)
expenses                                                                        
                                                                                
Sales and marketing                       (1,293)     (892)    (2,185)   (1,295)
                                                                                
Research and development                    (820)     (733)    (1,553)   (1,613)
                                                                                
Total expenses                            (2,556)   (4,451)    (7,007)   (8,576)
                                                                                
Operating loss                               (94)   (2,187)    (2,281)   (5,941)
                                                                                
Bank interest receivable                                            43       100
                                                                                
Interest payable                                                  (23)      (41)
                                                                                
Loss on ordinary                                               (2,261)   (5,882)
activities before taxation                                                      
                                                                                
Taxation on loss on                                                 19       221
ordinary activities                                                             
                                                                                
Loss on ordinary                                               (2,242)   (5,661)
activities after taxation                                                       
                                                                                
Basic loss per share           5                                  1.5p      5.6p
                                                                                
Diluted loss per share         5                                  1.5p      5.6p



Consolidated Balance Sheet as at 31 December 2004

                                     Unaudited    Audited         
                             Notes          31         31         
                                      December   December         
                                          2004       2003         
                                                                  
                                         �'000      �'000         
                                                                  
Fixed assets                                                      
                                                                  
Intangible                               1,882          -         
                                                                  
Tangible                                 1,851      1,171         
                                                                  
                                         3,733      1,171         
                                                                  
Current assets                                                    
                                                                  
Stocks                                   2,279        995         
                                                                  
Debtors                                  2,932      1,481         
                                                                  
Cash at bank and in hand                 2,542      4,244         
                                                                  
                                         7,753      6,720         
                                                                  
Creditors: amounts falling             (3,927)    (1,859)         
due within one year                                               
                                                                  
Net current assets                       3,826      4,861         
                                                                  
Total assets less current                7,559      6,032         
liabilities                                                       
                                                                  
Creditors: amounts falling                   -      (137)         
due after more than one                                           
year                                                              
                                                                  
Net Assets                               7,559      5,895         
                                                                  
Represented by:                                                   
                                                                  
Called up share capital                  2,129      1,337         
                                                                  
Share premium                           33,588     30,438         
                                                                  
Profit and loss account               (28,158)   (25,880)         
                                                                  
                               4         7,559      5,895         


Consolidated Statement of Total Recognised Gains and Losses

                                              Unaudited        Audited
                                                                      
                                             Year ended      18 months
                                            31 December       ended 31
                                                   2004  December 2003
                                                                      
                                                  �'000          �'000
                                                                      
Loss for the period                             (2,242)        (5,661)
                                                                      
Currency translation differences on                (36)              -
foreign currency net investments                                      
                                                                      
Total losses recognised                         (2,278)        (5,661)

Consolidated Cash Flow Statement for the year ended

31 December 2004

                                         Unaudited       Audited
                                                                
                                     Year ended 31     18 months
                                     December 2004      ended 31
                                                   December 2003
                                                                
                                             �'000         �'000 
                                                                
Net cash outflow from operating            (1,107)       (3,089)
activities                                                      
                                                                
Return on investments and servicing             20            59
of                                                              
finance                                                         
                                                                
Corporation tax refund                         180           323
                                                                
Capital expenditure                          (317)         (223)
                                                                
Acquisitions                               (3,838)             -
                                                                
Net cash outflow before financing          (5,062)       (2,930)
                                                                
Management of liquid resources                   -         2,802
                                                                
Financing                                    3,310         3,875
                                                                
(Decrease) / Increase in cash              (1,752)         3,747
                                                                

                                         Unaudited       Audited
                                                                
                                     Year ended 31     18 months
                                     December 2004      ended 31
                                                   December 2003
                                                                
Reconciliation of operating loss to          �'000         �'000
net cash outflow from operating                                 
activities:                                                     
                                                                
Operating loss                             (2,281)       (5,941)
                                                                
Depreciation                                   596         1,022
                                                                
Amortisation                                    56         1,783
                                                                
Decrease/(Increase) in stocks                  572         (155)
                                                                
Decrease/(Increase) in debtors                 228          (73)
                                                                
(Decrease)/Increase in creditors             (227)           255
                                                                
Decrease in current asset investment             -            20
                                                                
Other non-cash movements                      (51)             -
                                                                
Net cash outflow from operating            (1,107)       (3,089)
activities                                                      
                                                                

                                         Unaudited       Audited
                                                                
                                     Year ended 31     18 months
                                     December 2004      ended 31
                                                   December 2003
                                                                
Reconciliation of net cash flow to           �'000         �'000
movement in net funds:                                          
                                                                
(Decrease)/Increase in cash                (1,752)         3,747
                                                                
Cash inflow from short term deposits             -       (2,802)
                                                                
Cash outflow from lease financing              142           250
                                                                
Exchange differences on                       (37)             -
retranslation                                                   
                                                                
Change in net funds resulting from         (1,647)         1,195
cash flow                                                       
                                                                
New finance leases                               -         (499)
                                                                
Net funds at beginning of period             3,968         3,272
                                                                
Net funds at end of period                   2,321         3,968

Notes

1 Consolidated turnover for the year ended 31 December 2004

                                     Unaudited    Audited
                                                         
                                    Year ended  18 months
                                   31 December   ended 31
                                          2004   December
                                                     2003
                                                         
                                         �'000      �'000
                                                         
United Kingdom                           3,577      4,137
                                                         
Rest of Europe                           2,400        831
                                                         
Americas                                 3,350        472
                                                         
Asia                                       472        156
                                                         
Rest of World                              394         80
                                                         
                                        10,193      5,676
                                                         

Segmental analysis

Following the acquisition of Tepnel Lifecodes, Tepnel Diagnostics and Diaclone
Research, the Board believe there to be two distinct business classes being,
Research Products and Services, and Molecular Diagnostics. The businesses
included in the comparative figures form part of Research, Products and
Services.

Class of business                                                                 
                                                                                  
                               Unaudited                        Audited           
                                                                                  
                         2004 Class of business          2003 Class of business   
                                                                                  
                      Research                        Research                    
                      Products                        Products                    
                           and   Molecular                 and   Molecular        
                      Services Diagnostics   Total    Services Diagnostics   Total
                                                                                  
                         �'000       �'000   �'000       �'000       �'000   �'000
                                                                                  
TURNOVER                                                                          
                                                                                  
Total sales to third     4,068       6,125  10,193       5,676           -   5,676
parties                                                                           
                                                                                  
LOSS BEFORE TAXATION   (2,196)        (65) (2,261)     (5,882)           - (5,882)
                                                                                  
NET ASSETS                                                                        
                                                                                  
Segment net assets       7,689       (130)   7,559       5,895           -   5,895
                                                                                  

Geographical segments



                               Unaudited                                 Audited              
                                                                                            
                         2004 Geographical segments              2003 Geographical segments     
                                                                                            
                    UK    EU    US  Asia  Rest   Group         UK    EU    US  Asia  Rest   Group
                                            of                                         of        
                                         World                                      World        
                                                                                            
                 �'000 �'000 �'000 �'000 �'000   �'000      �'000 �'000 �'000 �'000 �'000   �'000
                                                                                            
TURNOVER                                                                                    
                                                                                            
Sales to third   3,577 2,400 3,350   472   394  10,193      4,137   831   472   156    80   5,676
parties by                                                                                  
geographical                                                                                
destination                                                                                 
                                                                                            
Sales to third   5,295    25 4,873     -     -  10,193      5,676     -     -     -     -   5,676
parties by                                                                                  
geographical                                                                                
origin                                                                                      
                                                                                            
LOSS BEFORE                                                                                 
TAXATION                                                                                    
                                                                                            
Segmental loss (2,094)  (29) (138)     -     - (2,261)    (5,882)     -     -     -     - (5,882)
                                                                                            
NET ASSETS                                                                                  
                                                                                            
Segment net      7,889  (30) (300)     -     -   7,559      5,895     -     -     -     -   5,895
assets                                                                                      
                                                                                            

2 Exceptional items

                                        Unaudited       Audited
                                                               
                                    Year ended 31     18 months
                                    December 2004      ended 31
                                                  December 2003
                                                               
                                            �'000         �'000
                                                               
Fixed asset impairment                          -           528
                                                               
Goodwill impairment                             -         1,642
                                                               
Foreign currency exchange loss                  -           178
                                                               
Redundancy costs1                              41             -
                                                               
Costs relating to restructuring and           506             -
relocation1                                                    
                                                               
                                              547         2,348

1 The lack of progress in sales of the Nucleoplex and Nucleopure instruments
systems has resulted in cessation of continued research, development, sales and
marketing activities associated with these products. The Company has provided
at year-end a total of �547,000, comprising �506,000 for write down of stocks
of the Nucleopure and Nucleoplex instruments systems held at 31 December 2004
and �41,000 for redundancy costs for people employed directly or indirectly on
these projects.

3 Fair value of assets acquired

Tepnel Life Sciences PLC acquired Tepnel Lifecodes and Tepnel Diagnostics,
formerly Orchid Diagnostics, on 21 January 2004 and Diaclone on 15 December
2004.

                                                   Unaudited            
                                                                        
Purchase of subsidiary                     Orchid    Diaclone      Total
undertakings                          Diagnostics                       
                                                                        
                                            �'000       �'000      �'000
                                                                        
Tangible fixed assets                         929          18        947
                                                                        
Stocks                                      1,321         534      1,855
                                                                        
Debtors                                       953         223      1,176
                                                                        
Prepayments                                   146          43        189
                                                                        
Cash at bank and in hand                       13          37         50
                                                                        
Creditors                                 (1,920)       (378)    (2,298)
                                                                        
Net assets acquired                         1,442         477      1,919
                                                                        
Goodwill                                      616       1,353      1,969
                                                                        
                                            2,058       1,830      3,888
                                                                        
less costs of acquisition                   (598)        (81)      (679)
                                                                        
Satisfied by cash                           1,460       1,749      3,209
                                                                        

                                                 Unaudited                     
                                                                               
Provisional fair value of                 Fair value adjustments               
assets acquired (Orchid                                                        
Diagnostics):                                                                  
                                                                               
                             Book value  Revaluations    Accounting  Fair value
                                                             policy            
                                                          alignment            
                                                                               
                                  �'000         �'000         �'000       �'000
                                                                               
Tangible fixed assets             1,897             -         (968)         929
                                                                               
Stocks                            1,395             -          (74)       1,321
                                                                               
Debtors                             982             -          (29)         953
                                                                               
Prepayments                         171             -          (25)         146
                                                                               
Cash at bank and in hand             13             -             -          13
                                                                               
Creditors                       (1,748)             -         (172)     (1,920)
                                                                               
                                  2,710             -       (1,268)       1,442
                                                                               
                                                 Unaudited                     
                                                                               
Provisional fair value of                 Fair value adjustments               
assets acquired (Diaclone):                                                    
                                                                               
                             Book value  Revaluations    Accounting  Fair value
                                                             policy            
                                                          alignment            
                                                                               
                                  �'000         �'000         �'000       �'000
                                                                               
Tangible fixed assets                18             -             -          18
                                                                               
Stocks                              807             -         (273)         534
                                                                               
Debtors                             223             -             -         223
                                                                               
Prepayments                          43             -             -          43
                                                                               
Cash at bank and in hand             37             -             -          37
                                                                               
Creditors                         (378)             -             -       (378)
                                                                               
                                    750             -         (273)         477
                                                                               
                                                 Unaudited                     
                                                                               
Total provisional fair                    Fair value adjustments               
value of assets acquired:                                                      
                                                                               
                             Book value Revaluations     Accounting  Fair value
                                                             policy            
                                                          alignment            
                                                                               
                                  �'000          �'000        �'000       �'000
                                                                               
Tangible fixed assets             1,915              -        (968)         947
                                                                               
Stocks                            2,202              -        (347)       1,855
                                                                               
Debtors                           1,205              -         (29)       1,176
                                                                               
Prepayments                         214              -         (25)         189
                                                                               
Cash at bank and in hand             50              -            -          50
                                                                               
Creditors                       (2,126)              -        (172)     (2,298)
                                                                               
                                  3,460              -      (1,541)       1,919

4 Reconciliation of movement of shareholders funds

                                        Unaudited         Audited
                                                                 
                                    Year ended 31 18 months ended
                                    December 2004     31 December
                                                             2003
                                                                 
                                            �'000           �'000
                                                                 
Loss for the year/period and net          (2,242)         (5,661)
increase in shareholders' deficit                                
                                                                 
Other recognised losses for the              (36)               -
year                                                             
                                                                 
Issue of shares (including premium)         3,942           4,224
                                                                 
Net additions/(reduction) to equity         1,664         (1,437)
shareholders' funds                                              
                                                                 
Opening equity shareholders funds           5,895           7,332
                                                                 
Closing equity shareholders funds           7,559           5,895
                                                                 

5 Loss per share

                                       Unaudited        Audited
                                                               
                                   Year ended 31      18 months
                                   December 2004       ended 31
                                                  December 2003
                                                               
Shares in issue (weighted average)   148,403,632    101,402,875
                                                               
Loss for period                       �2,242,000     �5,661,000
                                                               
Loss per share                           1.5p           5.6p
                                                              
Diluted loss per share                   1.5p           5.6p

6 Reconciliation of results for the 12 months ended 31 December 2003

                                   Unaudited           Audited        Unaudited
                              6 months ended   18 months ended  12 months ended
                                 31 December       31 December      31 December
                                        2002              2003             2003
                                                                               
                                       �000s             �000s            �000s
                                                                               
Sales                                  1,805             5,676            3,871
                                                                               
Cost of Sales                        (1,096)           (3,041)          (1,945)
                                                                               
                                                                               
                                                                               
Gross Profit                             709             2,635            1,926
                                                                               
Operating Expenses:                                                            
                                                                               
Research and Development               (515)           (1,613)          (1,098)
                                                                               
Sales and Marketing                    (469)           (1,295)            (826)
                                                                               
Administrative expenses              (1,153)           (3,320)          (2,167)
(excluding exceptional items)                                                  
                                                                               
Exceptional items                          -           (2,348)          (2,348)
(Administrative expenses)                                                      
                                                                               
                                                                               
                                                                               
Total Operating Expenses             (2,137)           (8,576)          (6,439)
                                                                               
                                                                               
                                                                               
Operating loss before interest       (1,428)           (5,941)          (4,513)
                                                                               
Interest                                  54               100               46
receivable                                                                     
                                                                               
Interest payable                         (1)              (41)             (40)
                                                                               
                                                                               
                                                                               
Loss before tax                      (1,375)           (5,882)          (4,507)
                                                                               
Taxation                                  57               221              164
                                                                               
Loss after tax                       (1,318)           (5,661)          (4,343)
                                                                               
Operating Loss before                (1,428)           (3,593)          (2,165)
exceptional items                                                              

7 The preliminary results for the year ended 31 December 2004 have been
approved by the Directors. Our Auditors have not issued a report on the results
for the year ended 31 December 2004 under Section 235 of the Companies Act
1985. The accounts for the year ended 31 December 2004 will be delivered to the
Registrar of Companies in due course. The financial information set out above
does not constitute statutory accounts within the meaning of Section 240 of the
Companies Act 1985. The audited information as at 31 December 2003 has been
extracted from the statutory accounts for the period ended 31st December 2003,
which have been delivered to the Registrar of Companies and whilst the audit
opinion was unqualified, the Auditors included an explanatory paragraph
regarding going concern.

8 The directors do not recommend the payment of a final dividend.

9 The operating loss is arrived at after writing off research and development
expenditure and exceptional items to the profit and loss account in the period
in which it was incurred

10 The accounting policies used are consistent with those applied in the latest
published company accounts.



END



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