Major shareholder announcement

Company announcement                                                                                        Orphazyme A/SNo. 05/2023                                                                                                             Ole Maaløes Vej 3DK-2200 Copenhagen N                                                                                                                                                       www.orphazyme.comCompany Registration No. 32266355

Copenhagen, Denmark, May 9, 2023 – Orphazyme A/S (ORPHA.CO) (the “Company”), hereby announces the receipt of notification pursuant to Section 38 of the Danish Capital Markets Act from Nordic Compound Invest A/S that Nordic Compound Invest A/S holds shares, corresponding to more than 5% of the total share capital and voting rights in the Company.

For additional information, please contact

Orphazyme A/S

Anders Vadsholt, Chief Executive Officer and Chief Financial Officer: +45 28 98 90 55

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