National Institutes of Health Awards Grant to SINTX Technologies for Development of 3D Printed Craniomaxillofacial Devices
March 10 2022 - 9:00AM
SINTX Technologies, Inc. (www.sintx.com) (NASDAQ: SINT) (“SINTX” or
the “Company”), an original equipment manufacturer of advanced
ceramics, announced today a Phase 1 grant of $300k awarded by the
National Institutes of Health (NIH) to develop, design and
characterize 3D printed implants for craniomaxillofacial (CMF)
applications using a composite of silicon nitride and
polyetherketoneketone (SN-PEKK). The Phase I grant represents the
second grant awarded to SINTX by the NIH in the past six months.
SINTX will collaborate with Drexel University,
Thomas Jefferson University, and the University of Pennsylvania
over the next 9-11 months to develop and test a new composite
material for implants that combines the flexibility and durability
of PEKK with the antibacterial and bone-integrating properties of
silicon nitride. If successful, the new material could be used in
place of other implant materials with higher failure rates and
greatly improve patient outcomes and reduce healthcare costs.
“The continued need for medical imaging
compatible 3D printed biomaterials for CMF osteoplasty that can be
personalized, promote integration, and prevent infection is
significant,” said Dr. Ryan Bock, Vice President of Research &
Development, SINTX Technologies. “We believe that this
high-performance silicon nitride PEKK material is a promising
biomaterial for CMF applications because of its antibacterial
activity, osseointegration, radiographic imaging, and durability.
We’re eager to demonstrate proof of concept through this NIH Phase
I grant.”
The U.S. government funded research grant aims
to provide a strong rationale and preliminary data to support the
further study and commercialization of 3D printable silicon nitride
PEKK composite for CMF implants which could substantially reduce
implant failures due to infection and poor bone integration. Today,
more than 235,000 Americans undergo CMF surgery annually, with
implant failure rates averaging 5.5 percent. Failures are often
attributed to infections, poor osseointegration, corrosion, and
fracture. Most can be linked to implant materials that underperform
in bioactivity, infection control, osseous integration, or
mechanical stability.
Americans undergo reconstructive surgery to
repair CMF damage due to injury or disease and receive treatment
for severe cranial and facial bone injuries using medical implants.
Pre-shaped metal, polymer, or bioactive implants are used in cases
that require bone repair or replacement; however, those materials
often fail due to poor osseointegration; prosthetic infections and
material degradation and fracture which often lead to revision
surgery, hardware removal, debridement, long-term antibiotic use,
and implant replacement. A better material is needed to overcome
these problems and SINTX believes its materials have the potential
to accelerate bone healing, reduce potential of infections,
eliminate metal toxicity, and enhance radiographic imaging.
Research reported in the “Development and
Pre-Clinical Testing of PEKK/Silicon Nitride Composite
Craniomaxillofacial Implants” proposal was supported by the
Department of Health and Human Sciences of the National Institutes
of Health under award number 1R43DE031456-01.
The content included in this release is solely
the responsibility of the authors and does not necessarily
represent the official views of the National Institutes of
Health.
About SINTX Technologies, Inc.
SINTX Technologies is an OEM ceramics company
that develops and commercializes advanced ceramics for medical and
non-medical applications including armor. The core strength of
SINTX Technologies is the manufacturing, research, and development
of ceramics for external partners. The Company presently
manufactures silicon nitride materials and components in its FDA
registered, ISO 13485:2016 certified, and ASD9100D certified
manufacturing facility and advanced ceramic materials in its SINTX
Armor facility both located in Salt Lake City, Utah.
For more information on SINTX Technologies
or its advanced ceramics material platforms, please
visit www.sintx.com.
Forward-Looking Statements
This press release contains forward-looking
statements within the meaning of the Private Securities Litigation
Reform Act of 1995 (PSLRA) that are subject to a number of risks
and uncertainties. Risks and uncertainties that may cause such
differences to include, among other things: our products may not
prove to be as effective as other products currently being
commercialized or to be commercialized in the future by
competitors; risks inherent in manufacturing and scaling up to
commercial quantities while maintaining quality controls;
volatility in the price of SINTX’s common stock; the uncertainties
inherent in new product development, including the cost and time
required to commercialize such product(s); market acceptance of our
products once commercialized; SINTX’s ability to raise funding and
other competitive developments. Readers are cautioned not to place
undue reliance on the forward-looking statements, which speak only
as of the date on which they are made and reflect management’s
current estimates, projections, expectations, and beliefs. There
can be no assurance that any of the anticipated results will occur
on a timely basis or at all due to certain risks and uncertainties,
a discussion of which can be found in SINTX’s Risk Factors
disclosure in its Annual Report on Form 10-K, filed with the
Securities and Exchange Commission (SEC) on March 22, 2021, and in
SINTX’s other filings with the SEC. SINTX undertakes no obligation
to publicly revise or update the forward-looking statements to
reflect events or circumstances that arise after the date of this
report.
Business Inquiries for SINTX:SINTX
Technologies801.839.3502IR@sintx.com
Media Inquiries for SINTX: Amanda Barry
Director of PR and ContentThe Summit Group abarry@summitslc.com
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