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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549
FORM 8-K
Current Report Pursuant
to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event Reported):
January 5, 2024
THERAVANCE BIOPHARMA, INC.
(Exact Name of Registrant as Specified in
its Charter)
Cayman Islands |
|
001-36033 |
|
98-1226628 |
(State or Other Jurisdiction of |
|
(Commission File Number) |
|
(I.R.S.
Employer Identification |
Incorporation) |
|
|
|
Number) |
PO Box 309
Ugland House, South Church Street
George Town, Grand Cayman, Cayman Islands KY1-1104
(650) 808-6000
(Addresses, including zip code, and telephone
numbers, including area code, of principal executive offices)
Check the appropriate box below if the Form 8-K filing
is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
¨ Written
communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
¨ Soliciting
material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
¨ Pre-commencement
communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
¨ Pre-commencement
communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
|
Trading
Symbol(s) |
|
Name of each exchange
on which registered |
Ordinary Share $0.00001 Par Value |
|
TBPH |
|
NASDAQ Global
Market |
Indicate by check mark whether the registrant is an emerging
growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2
of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging
growth company ¨
If an emerging
growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with
any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨
Item 8.01 Other Events
The information in this Current Report (including Exhibit 99.1)
is being furnished and shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934,
as amended, or otherwise subject to the liabilities of that Section. The information in this Current Report (including Exhibit 99.1)
shall not be incorporated by reference into any registration statement or other document pursuant to the Securities Act of 1933, as amended,
except as shall be expressly set forth by specific reference in such filing.
On January 5, 2024, Theravance Biopharma, Inc. issued a press
release to announce results from the Phase 4 PIFR-2 study of YUPELRI® (revefenacin) inhalation solution. A copy of the
press release is furnished as Exhibit 99.1 to this Current Report.
Item 9.01. |
Financial Statements and Exhibits. |
(d) Exhibits.
| 104 | Cover Page Interactive Data File (cover page XBRL tags embedded within the Inline XBRL document) |
SIGNATURE
Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|
THERAVANCE BIOPHARMA, INC. |
|
|
|
Date: January 5, 2024 |
By: |
/s/ Brett Grimaud |
|
|
Brett Grimaud |
|
|
General Counsel |
Exhibit 99.1
Theravance Biopharma Announces Results from
the Phase 4 YUPELRI® PIFR-2 Study in Patients with Severe to Very Severe Chronic Obstructive Pulmonary Disease (COPD)
DUBLIN– January 5, 2024 – Theravance Biopharma,
Inc. (NASDAQ: TBPH) today announced results from the Phase 4 PIFR-2 study of YUPELRI® (revefenacin) inhalation solution,
the only once-daily, nebulized long-acting muscarinic antagonist (LAMA) approved in the U.S. for maintenance treatment of COPD.
The PIFR-2 study aimed to demonstrate greater improvement in lung
function for YUPELRI delivered via standard jet nebulizer compared to Spiriva® (tiotropium) delivered via a dry powder
inhaler (Spiriva® HandiHaler®) in adults with severe to very severe COPD and suboptimal peak inspiratory
flow rate (PIFR).
| · | The
study did not show a statistically significant difference between YUPELRI and Spiriva HandiHaler
on the primary endpoint, change from baseline in trough forced expiratory volume in one second
(FEV1) at Day 85. |
| · | Similar
lung function improvement was demonstrated in both arms of the study. |
| · | YUPELRI
demonstrated safety and tolerability consistent with its profile in previous clinical studies. |
Chief Executive Officer Rick E Winningham said: “While the
primary endpoint in the Phase 4 PIFR-2 study was not met, YUPELRI demonstrated an efficacy and safety profile consistent with its performance
in other clinical studies. We appreciate the growth opportunities that lie ahead for YUPELRI, which is an important option for COPD maintenance
care, and look forward to sharing additional details from PIFR-2 in the future, following additional data analyses.”
About the PIFR-2 Study
The Phase 4 PIFR-2 Study (NCT05165485) is
a randomized, double-blind, parallel-group study, comparing improvements in lung function in adults with severe to very severe COPD (FEV1
<50% of predicted) and suboptimal PIFR (<55 L/min) following once-daily treatment over 12 weeks with either YUPELRI (revefenacin)
inhalation solution delivered via standard jet nebulizer or Spiriva (tiotropium) delivered via a dry powder inhaler (Spiriva HandiHaler).
YUPELRI is approved in the U.S. for the maintenance treatment of patients with COPD; Spiriva HandiHaler is approved in the U.S. for the
long-term, once-daily, maintenance treatment of bronchospasm associated with COPD, and for reducing COPD exacerbations.
About YUPELRI®
YUPELRI® (revefenacin) inhalation solution is a once-daily
nebulized long-acting muscarinic antagonist (LAMA) approved for the maintenance treatment of COPD in the U.S. LAMAs are recognized by
international COPD treatment guidelines as a cornerstone of maintenance therapy for COPD, regardless of severity of disease. Our market
research indicates there is an enduring population of COPD patients in the U.S. that either need or prefer nebulized delivery for maintenance
therapy. The stability of revefenacin in both metered dose inhaler and dry powder inhaler (“MDI/DPI”) formulations suggests
that revefenacin could also serve as a foundation for novel handheld combination products.
Important Safety Information
What is YUPELRI®?
| · | YUPELRI
is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD), a
long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both. |
| · | It
is an anticholinergic medicine which helps the muscles around the airway in your lungs stay
relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath. |
| · | It
is used long-term as 1 vial of YUPELRI, 1 time each day inhaled through your nebulizer to
improve symptoms of COPD for better breathing. |
Who should not use YUPELRI?
| · | Do
not use YUPELRI if you have sudden breathing problems. Always have a rescue inhaler with
you. |
| · | Do
not use YUPELRI if you have had an allergic reaction to revefenacin, or any of the other
ingredients in YUPELRI (sodium chloride, citric acid, sodium citrate). |
| · | Do
not use in children. It is not known if YUPELRI is safe and effective in children. |
Before using YUPELRI, tell your healthcare provider about all your
medical conditions, including if you:
| · | have
eye problems such as glaucoma. YUPELRI may make your glaucoma worse. |
| · | have
prostate or bladder problems, or problems passing urine. YUPELRI may make these problems
worse. |
| · | are
allergic to any of the ingredients in YUPELRI, or any other medicines. |
| · | are
pregnant or planning to become pregnant. It is not known if YUPELRI may harm your unborn
baby. |
| · | are
breastfeeding. It is not known if the medicine in YUPELRI passes into your breast milk and
if it can harm your baby. |
Tell your healthcare provider about all the medicines you take
including prescription and over-the-counter medicines, vitamins, and herbal supplements. YUPELRI and certain other medicines may
interact with each other. This may cause serious side effects.
Especially tell your healthcare provider if you take:
| · | Other
anticholinergics (including tiotropium, ipratropium, aclidinium, umeclidinium, glycopyrrolate) |
Know the medicines you take. Keep a list of them to show your healthcare
provider and pharmacist each time you get a new medicine.
What are the possible side effects with YUPELRI?
YUPELRI can cause serious side effects, including:
| · | Sudden
breathing problems immediately after inhaling your medicine. If you have sudden breathing
problems immediately after inhaling your medicine, stop using YUPELRI and call your healthcare
provider right away. |
| · | New
or worsened eye problems including acute narrow-angle glaucoma. Acute narrow-angle glaucoma
can cause permanent loss of vision if not treated. Symptoms may include: |
| o | Seeing halos or bright colors around lights |
| · | Urinary
retention. People who take YUPELRI may develop new or worse urinary retention. Symptoms
of urinary retention may include: |
| o | urination in a weak stream or drips |
If you have any of these symptoms, call your healthcare provider right
away before taking another dose.
| · | Serious
allergic reactions. Call your healthcare provider or get emergency medical care if you
get any of the following symptoms of a serious allergic reaction: |
| o | swelling of your face, mouth, and tongue |
| o | difficulty breathing or swallowing |
If you have any of these symptoms, stop taking YUPELRI, and call your
healthcare provider right away before taking another dose.
| · | Common
side effects of YUPELRI include: |
| o | Upper respiratory tract infection |
Tell your healthcare provider if you get any side effects that bother
you or that do not go away. These are not all the possible side effects with YUPELRI. Ask your healthcare provider or pharmacist for
more information. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I use YUPELRI?
Read the step by step instructions for using YUPELRI in the FDA-approved
Prescribing Information and at the end of this Patient Information Leaflet
| · | YUPELRI
is only for use with a nebulizer. |
| · | Do
not use YUPELRI more often than prescribed. |
| · | Do
not mix YUPELRI with other medicines in your nebulizer. |
| · | Do
not use other medicines that contain an anticholinergic for any reason. |
| · | Do
not stop using YUPELRI, even if you are feeling better, unless your healthcare provider
tells you to because your symptoms might get worse. |
| · | Call
your healthcare provider or get emergency medical care right away if |
| o | your breathing problems get worse. |
| o | you need to use your rescue inhaler medicine more often than usual. |
| o | your rescue inhaler medicine does not relieve your symptoms. |
This summary does not include all the information about YUPELRI
and is not meant to take the place of a discussion with your healthcare provider about your treatment.
About Theravance Biopharma
Theravance Biopharma, Inc.’s focus is to deliver Medicines that
Make a Difference® in people’s lives. In pursuit of its purpose, Theravance Biopharma leverages decades of expertise,
which has led to the development of FDA-approved YUPELRI® (revefenacin) inhalation solution indicated for the maintenance
treatment of patients with chronic obstructive pulmonary disease (COPD). Ampreloxetine, its late-stage investigational norepinephrine
reuptake inhibitor in development for symptomatic neurogenic orthostatic hypotension, has the potential to be a first in class therapy
effective in treating a constellation of cardinal symptoms in multiple system atrophy patients. The Company is committed to creating/driving
shareholder value.
For more information, please visit www.theravance.com.
THERAVANCE BIOPHARMA®, THERAVANCE®,
and the Cross/Star logo are registered trademarks of the Theravance Biopharma group of companies (in the U.S. and certain other countries).
YUPELRI® is a registered trademark of Mylan Specialty L.P., a Viatris company. Trademarks, trade names or service marks
of other companies appearing on this press release are the property of their respective owners.
About Theravance Biopharma / Viatris Collaboration
Theravance Biopharma and Viatris Inc. and their respective affiliates
have established a strategic collaboration to develop and commercialize nebulized revefenacin products for COPD.
Theravance Biopharma Forward-Looking Statements
This press release contains certain “forward-looking”
statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements
relating to goals, plans, objectives, expectations and future events. Theravance Biopharma intends such forward-looking statements to
be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934,
as amended, and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements relating to: future
YUPELRI sales and sales growth, timing of additional details from PIFR-2, and the ability to provide value to shareholders, the Company’s
regulatory strategies and timing of clinical studies, and possible safety, efficacy or differentiation of our investigational therapy.
These statements are based on the current estimates and assumptions of the management of Theravance Biopharma as of the date of this
press release and are subject to risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual
results of Theravance Biopharma to be materially different from those reflected in the forward-looking statements. Important factors
that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks
related to: whether the milestone thresholds can be achieved, delays or difficulties in commencing, enrolling or completing clinical
studies, the potential that results from clinical or non-clinical studies indicate the Company’s product candidates or product
are unsafe, ineffective or not differentiated, risks of decisions from regulatory authorities that are unfavorable to the Company, dependence
on third parties to conduct clinical studies, delays or failure to achieve and maintain regulatory approvals for product candidates,
risks of collaborating with or relying on third parties to discover, develop, manufacture and commercialize products, and risks associated
with establishing and maintaining sales, marketing and distribution capabilities with appropriate technical expertise and supporting
infrastructure, ability to retain key personnel, the ability of the Company to protect and to enforce its intellectual property rights,
volatility and fluctuations in the trading price and volume of the Company’s shares, and general economic and market conditions.
Other risks affecting Theravance Biopharma are in the Company’s Form 10-Q filed with the SEC on November 9, 2023, and other periodic
reports filed with the SEC. In addition to the risks described above and in Theravance Biopharma’s filings with the SEC, other
unknown or unpredictable factors also could affect Theravance Biopharma’s results. No forward-looking statements can be guaranteed,
and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these
forward-looking statements. Theravance Biopharma assumes no obligation to update its forward-looking statements on account of new information,
future events or otherwise, except as required by law.
Theravance Biopharma Contact:
investor.relations@theravance.com
650-808-4045
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