TIDMINS

RNS Number : 4681A

Instem plc

29 September 2015

29 September 2015

Instem plc

("Instem" or the "Group")

Half Yearly Report

Instem plc (AIM: INS.L), a leading provider of IT solutions to the global early development healthcare market, announces its unaudited interim results for the six months ended 30 June 2015.

Financial Highlights

   --     Revenues increased 31% to GBP7.5m (H1 2014: GBP5.7m) 

o Recurring revenues increased 19% to GBP5.0m representing 67% of total revenues (H1 2014: GBP4.2m representing 74% of total revenues)

   --     EBITDA increased to GBP0.9m (H1 2014: GBP0.1m) 
   --     Adjusted* earnings per share of 5.14p (H1 2014: 1.20p loss) 
   --     Basic earnings per share of 1.63p (H1 2014: 4.74p loss) 
   --     Seasonal net operating cash outflow of GBP1.0m (H1 2014: GBP1.6m) 
   --     Net cash balance as at 30 June 2015 of GBP0.1m (H1 2014: (GBP0.2m)) 

*After adjusting for the effect of foreign currency exchange on the revaluation of inter-Group balances included in finance income/(costs), non-recurring items and amortisation of intangibles on acquisitions.

Operational Highlights

   --     Demand intensified in both the pre-clinical and clinical sectors 
   --     Strong ALPHADAS order intake and market share gains 

-- SEND products and services poised for significant growth post definitive guidance from the FDA

-- Significant strengthening of the market facing team and project delivery capabilities both on and off-shore

Phil Reason, CEO of Instem plc, commented:

"Performance in the first half of 2015, from both a revenue and profit perspective, has continued the strengthening trends seen in the second half of 2014.

"Research and development pipelines in the pharma industry continue to grow, particularly in the earlier phases of development in which Instem specialises.

"With a solid backlog of existing orders, high levels of customer retention and a growing prospect pipeline, trading is expected to be in line with management expectations for the full year 2015 and we have confidence in the opportunities for 2016."

For further information, please contact:

 
 Instem plc                         +44 (0) 1785 825 600 
 Phil Reason, CEO                     www.instem.com 
 Nigel Goldsmith, CFO 
 
   N+1 Singer (Nominated Adviser 
   & Broker)                          +44 (0) 20 7496 3000 
 Richard Lindley 
  Nick Owen 
 
   Walbrook Financial PR              +44 (0) 20 7933 8000 
 Paul Cornelius                     instem@walbrookpr.com 
 Sam Allen 
 Helen Cresswell 
 

About Instem

Instem is a leading supplier of IT applications to the early development healthcare market, delivering compelling solutions for data collection, management and analysis across the R&D continuum. Instem applications are in use by customers worldwide, meeting the rapidly expanding needs of life science and healthcare organisations for data-driven decision making leading to safer, more effective products.

Instem's portfolio of software solutions increases client productivity by automating study-related processes while offering the unique ability to generate new knowledge through the extraction and harmonisation of actionable scientific information.

Instem supports over 400 clients through full service offices in the United States, the United Kingdom, India and China, with additional presence in France and Japan.

To learn more about Instem solutions and its mission, please visit www.instem.com

Chairman's Statement

I am pleased to report on the excellent financial performance achieved by the Group for the six month period to 30(th) June 2015.

We opened the year with a record order book, as a result of substantial pre-clinical business being secured towards the end of 2014. This strong financial performance resulted partly through successful execution of these contracts from this increased order book. In addition, the growth experienced in the pre-clinical market appears to be flowing through into early phase clinical trials with a consequential positive effect on sales of ALPHADAS, which added four new clients and eleven new clinical sites across Europe, Canada and the USA during the period.

Within the pre-clinical business, all Software-as-a-Service ("SaaS") Provantis(R) clients hosted from our US data centre have now upgraded to the latest version, enabling rationalisation and enhancement of the infrastructure. Increasing levels of new licensees within the small-to-mid sized contract research organisations ("CROs") industry sector demonstrates that the improving market sentiment is positively impacting all tiers of the industry. Perceptive Instruments, acquired in November 2013, also increased traction as part of the enlarged group, particularly with our clients in China and North America.

The Group has continued to invest for growth with the appointment of new senior hires within the SEND business, expansion of our Pune, India facility and recent establishment of an office in Tokyo, Japan to support our distributors and customers across the region.

The growth within the pharmaceutical industry, in terms of the number of enterprises working in the sector, the number of active substances undergoing research and the number of successful new product launches, provides one of the most positive market backdrops experienced by the Group in recent times. Consequently, the Group anticipates further growth in both its core pre-clinical and clinical markets across the second half of the year.

Finally, I would like to take this opportunity to thank all our staff, customers and partners for their ongoing support.

David Gare

Non-Executive Chairman

29 September 2015

Operational Review

Following our strong performance in the pre-clinical area at the end of 2014, we entered 2015 with a record order book and this has contributed to the financial progress of the Group in the period. The period has also seen a broadening of demand with the growth in pre-clinical being complemented by growth in the clinical business during the first half of 2015.

We have continued to invest to expand the scale and services provided from our Pune operation, which will be moving into larger premises during October 2015. Post the period end, Instem Japan was established and two experienced Japanese business development professionals have joined the Instem team. This will support a well-established Japanese client base and the increasing requirements for our regional distributors to convert a promising pipeline of opportunities.

Pre-clinical - Provantis(R) and Perceptive Instruments

Provantis client implementation projects progressed well during the period with all US-based SaaS clients now upgraded to the latest version of Provantis, enabling us to further optimise our data centre infrastructure.

The industry has continued to increase pre-clinical study volumes, which has generated additional Provantis licence sales at several of Instem's mid-sized CRO clients. There has also been a steady stream of customer upgrades and additional module purchases.

Perceptive Instruments has benefitted from being part of the enlarged Instem group with increasing cross selling during the period of its higher value AMES Study Manager and Cyto Study Manager products into existing Instem clients in China and North America.

Early Stage Clinical - ALPHADAS(TM)

2015 has been a very successful period for ALPHADAS in early phase clinical, with three significant new orders announced on 14 May 2015, involving implementation at nine additional clinics in Europe, Canada and the USA. Subsequently, we have received orders from three additional clients who will implement ALPHADAS at four further clinical sites.

Instem Scientific

As highlighted in the 2014 Annual Report, we are currently piloting a new service-based solution, 'KnowledgeScan', designed to leverage our powerful big data technology suite to answer important questions that arise during a typical drug development programme. Building on the expertise, scientific content, ontologies and vocabularies delivered on multiple prior projects, we believe this service fits well with the ongoing restructuring across the pharmaceutical industry, which has led to a significant increase in R&D outsourcing. We expect to see benefits from this industry-led change in the coming years, as demand for consulting expertise is usually a lead indicator of increasing demand for other products and services across this market segment.

Electronic Regulatory Submissions (SEND) - submit(TM)

The new business pipeline for both our software solutions and SEND data set conversion services continues to grow strongly month on month. While some of this will convert to orders and revenue in 2015, the more significant acceleration of revenue continues to be expected during 2016 and 2017, when submissions under the standard become mandatory. Management estimates that by 2019 the industry will be spending between $200m and $270m per year on software and services to generate SEND data, with much of the service work likely to be undertaken by CROs. Meanwhile, the Instem team has been extremely busy implementing the projects secured in 2014 and supporting the significant ramp up in interest generated by the publication of definitive guidance for SEND in December 2014.

We believe that submit(TM) offers the most advanced product to meet the requirements of SEND and Instem continues to secure the overwhelming majority of business placed in this area. As a consequence we have further strengthened the submit(TM) development, sales and implementation teams. In particular, we have hired two additional, highly experienced market facing consultants who have been key members on the SEND committee for over 10 years.

Market Overview

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As highlighted in our 2014 Annual Report, Citeline(R), which provides the world's most comprehensive source of real-time R&D intelligence for the pharmaceutical industry, reported that the size of the global drug pipeline had increased by 8.8% in 2014, alongside a 27% increase in market launches of new active substances. Supported by high capital inflows, the biggest growth segment was seen in the drug development activities of small to mid-tier pharma, with a year-on-year increase of more than 10% in the number of companies with an active drug development portfolio.

The growth in 2014 represented the largest annual rise in the drug pipeline on record, in absolute terms and followed on from the strong advance seen in 2013. There is further evidence that the global pharmaceutical market is now moving resources from late stage clinical development into early compound development work in order to refill the pipeline of preclinical candidates.

These drug development activities require specialist services and technologies, in particular, IT solutions, which enable organisations to improve cost efficiencies and ensure that they are able to meet the ever increasing regulatory demands of the industry. The regulatory bodies' preference for the electronic capture, storage and transfer of data for new drug submissions continues to grow. Pharmaceutical organisations are seeking tools that can help them to identify suitable drug candidates from vast volumes of historic data, in addition to managing their compliance risk with the authorities.

Pre-clinical market

In August 2015, Charles River Laboratories (CRL), a $1.3bn revenue company, which is also the world's largest preclinical CRO, reported that "Demand for outsourced early-stage service continues to intensify" with revenue for their drug safety assessment business enjoying a 3(rd) successive quarter of low double digit revenue growth. This trend is in evidence amongst many of Instem's other CRO clients and supports the continued robustness of Instem's sales pipeline.

CRL is also the world's largest supplier of laboratory research models and it is witnessing increasing customer demand, particularly in China and North America, with demand stable in Europe. This trend reflects what Instem is experiencing with regard to market expenditure on IT solutions across these territories.

Early Stage Clinical market

The recent market study from Citeline(R) reported a 4.9% increase in the early stage clinical pipeline, and this supports anecdotal evidence that the early stage clinical market is growing more slowly than pre-clinical, with some CROs reporting marked increases in study volume and others still with capacity to spare.

The early stage clinical market is immediately downstream of pre-clinical and there may therefore be a delay before the increased pre-clinical investment delivers an improved flow of drug candidates to the clinic. The restructuring of the early phase clinical CRO market, as experienced in recent years, is expected to continue with CRO performance quite variable.

Nevertheless, strong opportunities exist within the early stage clinical market for the deployment of Instem's software solutions. These opportunities are resulting from an increasing recognition of the need to control data quality and integrity and because levels of automation within the early stage environment remain low in comparison with other areas of pharma R&D.

Government and Academic Research

Funding for Government and academic institutions undertaking later stages of life sciences research in North America, China and Europe continues to grow to cover gaps that are not sufficiently attractive to commercial enterprises. This enables them to invest in both study automation solutions and in innovative approaches to the process of R&D using novel, scientific informatics and big data approaches.

Instem revenue in this sector of the market has grown, over the last 5 years, from a negligible proportion to approaching 10% of total revenue. It remains one of the target areas for further growth.

Financial Review

Instem's revenue model consists of a blend of fees for perpetual licences and annual support, SaaS subscriptions and professional services. In the period, approximately 67% (H1 2014: 74%) of revenues were recurring in nature, being derived from annual support fees, SaaS subscriptions, funded software development and upgrade services.

Earnings from operations before depreciation, amortisation, non-recurring costs, interest and tax ('EBITDA') for the period, was GBP0.9m (H1 2014: GBP0.1m). Operating expenses increased by GBP0.9m in the half year over the equivalent period in 2014, largely due to the ongoing investment in staff. Amortisation remained at GBP0.5m compared with the equivalent period in 2014.

Development expenditure in the period was GBP0.9m (H1 2014: GBP0.5m), of which GBP0.2m was capitalised (H1 2014: GBP0.1m).

The funding deficit of Instem's defined benefit pension scheme remained at GBP4.0m during the period, calculated in accordance with the provisions of IAS19.

Instem's cash flow displays some seasonality, with cash inflow being weighted towards the second half of the year, resulting from the level of annual fee renewals occurring at the year end. As a result of the normal working capital cycle, net cash at the end of June 2015 was GBP0.1m (H1 2014: GBP(0.2)m) compared with GBP1.7m at December 2014. Cash payments of GBP0.6m were also made in the period for contingent consideration relating to the acquisition of Perceptive Instruments and the settlement of a loan note, which was issued as part payment of contingent consideration relating to the acquisition of Logos (Instem Clinical).

In line with previous periods, and our current policy of retaining cash within the business to capitalise on the available growth opportunities, the Board has not recommended the payment of a dividend.

Principal risks and uncertainties

The principal risks and uncertainties remain unchanged from those described in our 2014 Annual Report.

Outlook

Performance in the first half of 2015, from both a revenue and profit perspective, has continued from the strengthening trends seen in the second half of 2014.

Research and Development pipelines in the pharma industry continue to grow, particularly in the earlier phases of development in which Instem specialises.

With a solid backlog of existing orders, high levels of customer retention and a growing prospect pipeline, trading is expected to be in line with management expectations for the full year 2015 and we have confidence in the opportunities for 2016.

Phil Reason

Chief Executive

29 September 2015

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

For the six months ended 30 June 2015

 
                                                                           Unaudited        Unaudited          Audited 
                                                                          Six months       Six months             Year 
                                                                               ended            ended         ended 31 
                                                                             30 June          30 June    December 2014 
                                                                                2015             2014           GBP000 
                                                             Note             GBP000           GBP000 
 
 REVENUE                                                                       7,479            5,701           13,429 
 Operating expenses                                                          (6,500)          (5,563)         (11,513) 
 Share based payment                                                            (85)             (41)            (108) 
 
 EARNINGS BEFORE DEPRECIATION, AMORTISATION, NON 
  RECURRING ITEMS, INTEREST AND TAX ("EBITDA")                                   894               97            1,808 
 
 Depreciation                                                                   (98)             (90)            (186) 
 Amortisation of internally generated intangibles                              (194)            (144)            (297) 
 Amortisation of acquired intangibles                                          (320)            (320)            (640) 
                                                                   -----------------  ---------------  --------------- 
 Total amortisation                                                            (514)            (464)            (937) 
                                                                   -----------------  ---------------  --------------- 
 
 
 PROFIT/(LOSS) BEFORE NON RECURRING ITEMS                                        282            (457)              685 
 
   Non-recurring costs                                       4                     -             (38)            (123) 
                                                                   -----------------  ---------------  --------------- 
 PROFIT/(LOSS) FROM OPERATIONS                                                   282            (495)              562 
 
 Finance income                                                                  108                1                9 
 Finance costs                                                                 (116)            (178)            (359) 
                                                                   -----------------  ---------------  --------------- 
 PROFIT/(LOSS) BEFORE TAXATION                                                   274            (672)              212 
 
   Income tax                                                   5               (75)              105             (62) 
                                                                   -----------------  ---------------  --------------- 
 PROFIT/(LOSS) FOR THE PERIOD/YEAR                                               199            (567)              150 

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                                                                   -----------------  ---------------  --------------- 
 
 OTHER COMPREHENSIVE EXPENSE 
 Actuarial loss on retirement benefit obligations                              (339)            (240)            (621) 
 Deferred tax on actuarial loss                                                   68               48              124 
 
 Exchange differences on translating foreign operations                         (28)                1               34 
                                                                   -----------------  ---------------  --------------- 
 
 OTHER COMPREHENSIVE EXPENSE FOR THE PERIOD/YEAR                               (299)            (191)            (463) 
                                                                   -----------------  ---------------  --------------- 
 
 
   TOTAL COMPREHENSIVE EXPENSE FOR THE PERIOD/YEAR                             (100)            (758)            (313) 
                                                                   =================  ===============  =============== 
 
   PROFIT/(LOSS) ATTRIBUTABLE TO EQUITY HOLDERS OF THE 
   PARENT GROUP                                                                  199            (567)              150 
                                                                   =================  ===============  =============== 
 
   TOTAL COMPREHENSIVE EXPENSE ATTRIBUTABLE TO EQUITY 
   HOLDERS OF THE PARENT GROUP                                                 (100)            (758)            (313) 
                                                                   =================  ===============  =============== 
 
 Earnings per Share from continuing operations 
  - Basic                                                       3              1.63p          (4.74)p            1.24p 
                                                - 
                                                 Diluted        3              1.61p          (4.74)p            1.23p 
 

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

As at 30 June 2015

 
                                    Unaudited   Unaudited       Audited 
                                           30          30   31 December 
                                         June        June          2014 
                                         2015        2014 
                                       GBP000      GBP000        GBP000 
 ASSETS 
 NON-CURRENT ASSETS 
 Intangible assets                     11,953      12,734        12,439 
 Property, plant and equipment            392         292           263 
 Deferred tax assets                      543         395           574 
                                   ----------  ----------  ------------ 
 TOTAL NON-CURRENT ASSETS              12,888      13,421        13,276 
 
 CURRENT ASSETS 
 Inventories                              798         397           506 
 Trade and other receivables            5,595       2,508         4,432 
 Current tax assets                         -         385             - 
 Cash and cash equivalents              1,600       1,127         1,676 
                                   ----------  ----------  ------------ 
 TOTAL CURRENT ASSETS                   7,993       4,417         6,614 
 
 TOTAL ASSETS                          20,881      17,838        19,890 
                                   ==========  ==========  ============ 
 
 LIABILITIES 
 CURRENT LIABILITIES 
 Bank overdraft                         1,540       1,318             - 
 Trade and other payables               7,826       5,846         8,175 
 Current tax liabilities                  406           -           231 
 Short term borrowing                      18           -             - 
 Financial liabilities                  1,300       1,100         1,903 
                                   ----------  ----------  ------------ 
 TOTAL CURRENT LIABILITIES             11,090       8,264        10,309 
 
 NON-CURRENT LIABILITIES 
 Long term borrowing                      136           -             - 
 Financial liabilities                    299       1,557           281 
 Retirement benefit obligations         3,952       3,510         3,881 
                                   ----------  ----------  ------------ 
 TOTAL NON-CURRENT LIABILITIES          4,387       5,067         4,162 
 
 TOTAL LIABILITIES                     15,477      13,331        14,471 
                                   ----------  ----------  ------------ 
 
 EQUITY 
 Share capital                          1,221       1,200         1,221 
 Share premium                          7,892       7,892         7,892 
 Merger reserve                         (326)       (706)         (326) 
 Shares to be issued                      463         311           378 
 Translation reserve                      200         195           228 
 Retained earnings                    (4,046)     (4,385)       (3,974) 
                                   ----------  ----------  ------------ 
 
 TOTAL EQUITY ATTRIBUTABLE TO 
  EQUITY HOLDERS OF THE PARENT          5,404       4,507         5,419 
 
 TOTAL EQUITY AND LIABILITIES          20,881      17,838        19,890 
                                   ==========  ==========  ============ 
 

CONSOLIDATED STATEMENT OF CASH FLOWS

For the six months ended 30 June 2015

 
                                                              Unaudited          Unaudited                   Audited 
                                                       Six months ended   Six months ended                      Year 
                                                                30 June            30 June    ended 31 December 2014 
                                                                   2015               2014                    GBP000 
                                                                 GBP000             GBP000 
 CASH FLOWS FROM OPERATING ACTIVITIES 
 Profit/(loss) before taxation                                      274              (672)                       212 
 
 Adjustments for: 
 Depreciation                                                        98                 90                       127 
 Amortisation of intangibles                                        514                464                       937 
 Share based payments and shares to be issued                        85                 41                       108 
 Retirement benefit obligations                                   (337)              (310)                     (398) 
 Net foreign exchange loss                                            -               (65)                         - 
 Finance income                                                   (108)                (1)                       (9) 
 Finance costs                                                      116                178                       359 
 
 
   CASH FLOWS FROM OPERATIONS BEFORE MOVEMENTS IN 
   WORKING CAPITAL                                                  642              (275)                     1,336 
 
 Changes in working capital: 
 Increase in inventories                                          (297)               (99)                     (196) 
 (Increase)/decrease in trade and other receivables             (1,238)                215                   (1,436) 
 (Decrease)/increase in trade and other payables                  (267)            (1,132)                       743 
                                                     ------------------  -----------------  ------------------------ 
 
   CASH (USED IN)/GENERATED FROM OPERATIONS                     (1,160)            (1,291)                       447 
 
 Finance costs                                                     (34)               (17)                      (65) 
 Income tax received/(paid)                                         199              (246)                       100 
                                                     ------------------  -----------------  ------------------------ 
 
   NET CASH (USED IN)/GENERATED FROM OPERATING 
   ACTIVITIES                                                     (995)            (1,554)                       482 
                                                     ------------------  -----------------  ------------------------ 
 
 CASH FLOWS FROM INVESTING ACTIVITIES 
 Finance income received                                              -                  1                         9 
 Purchase of intangible assets                                     (28)              (311)                     (369) 
 Purchase of property, plant and equipment                         (72)              (119)                     (124) 
 Acquisition - Cash consideration                                 (598)              (200)                     (302) 
 
 
 
   NET CASH USED IN INVESTING ACTIVITIES                          (698)              (629)                     (786) 
                                                     ------------------  -----------------  ------------------------ 
 
 CASH FLOWS FROM FINANCING ACTIVITIES 
 Proceeds from borrowings                                             -                  -                         - 
 
 
   NET CASH GENERATED FROM FINANCING ACTIVITIES                       -                  -                         - 
                                                     ------------------  -----------------  ------------------------ 
 
 NET DECREASE IN CASH AND CASH EQUIVALENTS                      (1,693)            (2,183)                     (304) 
 Cash and cash equivalents at start of year                       1,676              2,053                     2,053 
 Effect of exchange rate changes on the balance of 
  cash held in foreign currencies                                    77               (61)                      (73) 
                                                     ------------------  -----------------  ------------------------ 
 

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   CASH AND CASH EQUIVALENTS AT END OF PERIOD/YEAR                   60              (191)                     1,676 
                                                     ==================  =================  ======================== 
 

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

For the six months ended 30 June 2015

 
                         Called up   Share Premium     Merger    Shares to be   Translation         Retained     Total 
                     share capital                    Reserve          issued       Reserve         earnings    Equity 
                            GBP000          GBP000     GBP000          GBP000        GBP000           GBP000    GBP000 
 
 Balance as at 1 
  January 2014               1,176           7,892      (932)             270           194          (3,627)     4,973 
 
 
 Loss for the 
  period                         -               -          -               -             -            (567)     (567) 
 Other 
  comprehensive 
  income/(expense)               -               -          -               -             1            (191)     (190) 
                    --------------  --------------  ---------  --------------  ------------  ---------------  -------- 
 Total 
  comprehensive 
  income                         -               -          -               -             1            (758)     (757) 
 
 Shares issued                  24               -        226               -             -                -       250 
 Share based 
  payment                        -               -          -              41             -                -        41 
                    --------------  --------------  ---------  --------------  ------------  ---------------  -------- 
 
   Balance as at 
   30 June 2014              1,200           7,892      (706)             311           195          (4,385)     4,507 
 
 Profit for the 
  period                         -               -          -               -             -              717       717 
 Other 
  comprehensive 
  income/(expense)               -               -          -               -            33            (306)     (273) 
                    --------------  --------------  ---------  --------------  ------------  ---------------  -------- 
 Total 
  comprehensive 
  income                         -               -          -               -            33              411       444 
 
 Shares issued                  21               -        380               -             -                -       401 
 Share based 
  payment                        -               -          -              67             -                -        67 
                    --------------  --------------  ---------  --------------  ------------  ---------------  -------- 
 
   Balance as at 
   31 December 
   2014                      1,221           7,892      (326)             378           228          (3,974)     5,419 
 
 
 Profit for the 
  period                         -               -          -               -             -              199       199 
 Other 
  comprehensive 
  expense                        -               -          -               -          (28)            (271)     (299) 
                    --------------  --------------  ---------  --------------  ------------  ---------------  -------- 
 Total 
  comprehensive 
  income                         -               -          -               -          (28)             (72)     (100) 
 
 
 Share based 
  payment                        -               -          -              85             -                -        85 
                    --------------  --------------  ---------  --------------  ------------  ---------------  -------- 
 
   Balance as at 
   30 June 2015              1,221           7,892      (326)             463           200          (4,046)     5,404 
                    ==============  ==============  =========  ==============  ============  ===============  ======== 
 

NOTES TO THE FINANCIAL INFORMATION

For the six months ended 30 June 2015

GENERAL INFORMATION

The principal activity of Instem plc and its subsidiaries is the provision of world class IT systems and services for the global life sciences community.

Notes to the accounts

   1.         Basis of preparation and accounting policies 

Basis of preparation

The Group's half-yearly financial information, which is unaudited, consolidates the results of Instem plc and its subsidiary undertakings made up to 30 June 2015. The Group's accounting reference date is 31 December.

The Group is a public limited liability Group incorporated and domiciled in England & Wales. The consolidated financial information is presented in Pounds Sterling (GBP) which is also the functional currency of the parent.

The financial information contained in this half-yearly financial report does not constitute statutory accounts as defined in section 434 of the Companies Act 2006. It does not therefore include all of the information and disclosures required in the annual financial statements.

The financial information for the six months ended 30 June 2014 is unaudited.

Instem plc's consolidated statutory accounts for the year ended 31 December 2014, prepared under IFRS, have been delivered to the Registrar of Companies. The report of the auditors on these accounts was unqualified and did not contain a statement under Section 498 (2) or (3) of the Companies Act 2006.

The Consolidated Statement of Comprehensive Income has been amended from prior periods to show a sub-totalled amount for Earnings before Depreciation, Amortisation, Non-recurring items, Interest and Tax ('EBITDA'). Prior period comparable figures have been restated accordingly. The Directors have made this adjustment to better reflect the underlying trading performance of the business and show a commonly used measure for comparability with other businesses and sectors.

Significant accounting policies

The accounting policies used in the preparation of the financial information for the six months ended 30 June 2015 are in accordance with the recognition and measurement criteria of International Financial Reporting Standards ('IFRS') as adopted by the European Union and are consistent with those which will be adopted in the annual statutory financial statements for the year ending 31 December 2015.

While the financial information included has been prepared in accordance with the recognition and measurement criteria of International Financial Reporting Standards (IFRS), as adopted by the European Union (EU), these financial statements do not contain sufficient information to comply with IFRS's.

Instem plc and its subsidiaries have not applied IAS 34, Interim Financial Reporting, which is not mandatory for UK AIM listed Groups, in the preparation of this half-yearly financial report.

Cash and cash equivalents

Cash and cash equivalents for the purposes of the Statement of Cash Flows comprise the net of cash and overdraft balances that are shown on the Statement of Financial Position in Cash and Cash Equivalents and Current Financial Liabilities.

   2.         Segmental Information 

The Directors consider that the Group operates in one business segment, being IT solutions to the global early development healthcare market, and that therefore there are no additional segmental disclosures to be made in these financial statements.

   3.         Earnings per Share 

(a) Basic

 
                                     Six months 
                                          ended        Six months     Year ended 
                                        30 June             ended    31 December 
                                           2015           30 June           2014 
                                      Unaudited    2014 Unaudited        Audited 
 
 Profit/(Loss) after tax (GBP000)           199             (567)            150 
                                    -----------  ----------------  ------------- 
 
 Weighted average number of 
  shares (000's)                         12,212            11,954         12,063 
                                    -----------  ----------------  ------------- 
 
 Basic earnings/(loss) per share 
  (p per share)                            1.63            (4.74)           1.24 
                                    ===========  ================  ============= 
 
             (b)   Diluted 
 
                                     Six months 
                                          ended        Six months     Year ended 
                                        30 June             ended    31 December 
                                           2015           30 June           2014 
                                      Unaudited    2014 Unaudited        Audited 
 
 Profit/(Loss) after tax (GBP000)           199             (567)            150 
                                    -----------  ----------------  ------------- 
 
 Weighted average number of 
  shares (000's)                         12,212            11,954         12,063 
 
 Adjustments for share options 
  (000's)                                   177                 -            155 
 
 Adjusted weighted average 
  number of shares (000's)               12,389            11,954         12,218 
                                    -----------  ----------------  ------------- 
 
 Diluted earnings/(loss) per 
  share (p per share)                      1.61            (4.74)           1.23 
                                    ===========  ================  ============= 
 

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