The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.
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Report for the Calendar Year or Quarter Ended:
Check here if Amendment:      Amendment Number:
This Amendment (Check only one.):      is a restatement.
       adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name: Banco Santander, S.A. 
Address: Ciudad Grupo Santander 
  Boadilla Del Monte 
  Madrid  U3  28660 
Form 13F File Number:   028-04177 

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name: Jose Galiana Guiu 
Title: Deputy Chief Accounting Officer 
Phone: 34-615-900-262 

Signature, Place, and Date of Signing:

/s/ Jose Galiana Guiu  Madrid,  SPAIN 05-05-2021 
[Signature] [City, State] [Date]

Do you wish to provide information pursuant to Special Instruction 5?        Yes     X  No

Report Type (Check only one.):

X  13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)

     13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)

     13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)

Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
Form 13F Information table Entry Total: 681 
Form 13F Information table Value Total: 14,189,260 

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F number(s) of all institutional investement managers with respect to which this report is filed, other than the manager filing this report.

   No. Form 13F File Number Name CIK
028-17923  Banco Santander International, S.A.   
028-17917  Banco Santander International   
028-17920  Santander Holdings USA, Inc.   
028-18759  SAM Investment Holdings, S.L.   
028-20720  Grupo Empresarial Santander, S.L.   
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