By Denny Jacob

 

Pharvaris NV shares soared 79%, to $4.50, in early trading after the company said data on PHVS416 demonstrated statistically significant results for treatment of hereditary angioedema, a hereditary condition that causes recurrent swelling.

Top-line data from the Phase 2 study of PHVS416 for the prophylactic treatment of hereditary angioedema is expected in the second half of 2023, said Chief Executive Berndt Modig. Data from the proof-of-concept study is expected to inform the design of expected Phase 3 utilizing PHVS719, an investigational treatment currently in Phase 1 clinical development for hereditary angioedema.

The clinical-stage biopharmaceutical company also said it is continuing to work with the U.S. Food and Drug Administration to resolve holds on clinical trials for PHA121, which the company describes as a competitive antagonist of the bradykinin B2 receptor.

 

Write to Denny Jacob at denny.jacob@wsj.com

 

(END) Dow Jones Newswires

December 08, 2022 10:20 ET (15:20 GMT)

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