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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported)
November 13, 2023
CARA THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
Delaware |
|
001-36279 |
|
75-3175693 |
(State or other jurisdiction
of incorporation) |
|
(Commission
File Number) |
|
(IRS Employer
Identification No.) |
|
|
|
|
|
4 Stamford Plaza
107 Elm Street, 9th Floor
Stamford, Connecticut |
|
|
|
06902 |
(Address of principal executive offices) |
|
|
|
(Zip Code) |
|
|
|
|
|
Registrant's telephone number, including area code (203) 406-3700 |
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2.):
¨ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
¨ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
¨ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
¨ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
Title
of each class |
Trading
Symbol |
Name
of each exchange on which registered |
Common Stock, par value $0.001 per share |
CARA |
The Nasdaq Stock Market LLC |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ¨
If an emerging growth company, indicate by
check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨.
Item 2.02. |
Results of Operations and Financial Condition. |
On November 13, 2023, Cara Therapeutics, Inc. (the “Company”)
issued a press release announcing its financial results for the third quarter ended September 30, 2023. A copy of the press
release is being furnished to the Securities and Exchange Commission as Exhibit 99.1 to this Current Report on Form 8-K and
is incorporated by reference to this Item 2.02.
The information furnished pursuant to this Item 2.02, including Exhibit 99.1,
shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange
Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed to be incorporated by reference into any of
the Company’s filings with the Securities and Exchange Commission under the Exchange Act or the Securities Act of 1933, as amended,
whether made before or after the date hereof, regardless of any general incorporation language in such a filing.
Item 9.01. |
Financial Statements and Exhibits. |
(d)
Exhibits
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|
CARA THERAPEUTICS, INC.
|
|
By: |
/s/ RYAN MAYNARD |
|
|
Ryan Maynard |
|
|
Chief Financial Officer |
|
|
(Principal Financial and Accounting Officer) |
Date: November 13, 2023
Exhibit 99.1
Cara Therapeutics Reports Third Quarter 2023
Financial Results
– Non-dilutive financing agreement with
HealthCare Royalty for up to $40 million expected to extend cash runway into 2025 –
– Key data readouts for all three late-stage
oral difelikefalin clinical programs anticipated within current financial runway –
– Topline results from Part A of
KIND 1 Phase 3 atopic dermatitis trial expected in December 2023 –
– 3Q23 total revenue of $4.9M including
collaborative revenue of $1.9M from the Company’s share of profit of KORSUVA® (difelikefalin) injection –
– Conference call today at 4:30 p.m. EST
–
STAMFORD, Conn., November 13, 2023
– Cara Therapeutics, Inc. (Nasdaq: CARA), a commercial-stage biopharmaceutical company leading a new treatment paradigm
to improve the lives of patients suffering from pruritus, today announced financial results and operational highlights for the third
quarter ended September 30, 2023.
“We are pleased to have closed our non-dilutive
financing transaction with HealthCare Royalty, which extends our cash runway into 2025,” said Christopher Posner, President and
Chief Executive Officer of Cara Therapeutics. “This financing will help us reach key clinical catalysts which we believe will validate
the potential of our oral difelikefalin pipeline.”
Mr. Posner continued, “We look forward
to releasing topline efficacy and safety data from Part A of our KIND 1 atopic dermatitis (AD) trial in December. Our other two
late-stage clinical programs for the treatment of pruritus associated with advanced chronic kidney disease (CKD) and notalgia paresthetica
(NP) are on track for key data readouts in 2024. We will continue to focus on maintaining a strong balance sheet and delivering on our
commitments across our wholly owned pipeline.”
3Q23 and Recent Highlights
| · | Entered
into Royalty Interest Purchase and Sale Agreement with HealthCare Royalty (HCRx) for up to
$40 million, extending Cara’s cash runway into 2025 |
| · | Topline
efficacy and safety data from Part A of the KIND 1 Phase 3 program in pruritus associated
with AD expected in December 2023 |
| · | Enrollment
on track in the KICK Phase 3 program in pruritus associated with advanced CKD, with topline
results expected in 2H24 |
| · | Enrollment
also on track in the KOURAGE Phase 2/3 program in NP, with readout from Part A targeted
in 2H24 and final topline results for the program in 1H26 |
| · | Findings
from the Neuropathic Itch Patient Survey (NIRVE) were reported in an oral presentation at
the EADV Congress 2023 |
| · | Centers
for Medicare & Medicaid Services issued the CY 2024 End Stage Renal Disease Prospective
Payment System final rule |
| · | Helen
M. Boudreau was appointed to the Company’s Board of Directors and will serve as Chair
of the Audit Committee |
| · | Harrison
M. Bains retired from the Company’s Board of Directors |
KORSUVA Injection U.S. Update: 3Q23
In the third quarter of 2023, KORSUVA injection
generated net sales of $4.4 million and the Company recorded collaborative revenue of $1.9 million, which represented the Company’s
share of the profit from sales of KORSUVA injection.
Wholesalers shipped 90,828 vials to dialysis
centers during the third quarter of 2023. Vial orders increased 36% quarter to quarter.
In October 2023, the Centers for Medicare &
Medicaid Services (CMS) issued a final rule for the End Stage Renal Disease Prospective Payment System (ESRD PPS) for calendar year
2024, which confirmed the TDAPA period for KORSUVA injection until March 31, 2024, and maintained the reimbursement methodology
from the June 2023 proposed rule.
Upcoming Meeting Activities
The Company expects to present at the following
upcoming investor conferences:
| · | Stifel
Healthcare Conference, November 15, 2023, at 10:55 a.m. EST |
| · | Jefferies
London Healthcare Conference, November 16, 2023, at 8:00 a.m. GMT |
| · | Piper
Sandler Healthcare Conference, November 29, 2023, at 4:30 p.m. EST |
Third Quarter 2023 Financial Results
Cash, cash equivalents and marketable securities
at September 30, 2023 totaled $83.3 million compared to $156.7 million at December 31, 2022. The decrease in the balance primarily
resulted from $74.7 million of cash used in operating activities.
For the third quarter of 2023, net loss was $28.0
million, or $(0.52) per basic and diluted share, compared to net loss of $23.2 million, or $(0.43) per basic and diluted share, for the
same period in 2022.
Revenues: Total revenue was $4.9 million
and $10.8 million for the three months ended September 30, 2023 and 2022, respectively. Revenue consisted of:
| · | $1.9
million and $7.4 million of collaborative revenue related to our share of the profit from
CSL Vifor’s sales of KORSUVA injection to third parties during the three months ended
September 30, 2023 and 2022, respectively. In addition, $0.5 million of collaborative
revenue was recognized during the three months ended September 30, 2023. This amount
relates to an allocated portion of the regulatory milestone payment we earned in September 2023
from Maruishi Pharmaceuticals Co. Ltd, or Maruishi, for the marketing approval in Japan for
KORSUVA injection; |
| · | $1.3
million and $3.4 million of commercial supply revenue related to sales of KORSUVA injection
to CSL Vifor during the three months ended September 30, 2023 and 2022, respectively; |
| · | Approximately
$167,000 of royalty revenue related to our royalties on the net sales of Kapruvia in Europe
during the three months ended September 30, 2023. There was no royalty revenue during
the three months ended September 30, 2022; and |
| · | $0.9
million of license and milestone fees revenue related to the remaining allocated portion
of a regulatory milestone payment we earned in September 2023 from Maruishi for the
marketing approval in Japan for KORSUVA injection. There was no license and milestone fees
revenue during the three months ended September 30, 2022. |
Cost of Goods Sold: Cost of goods sold
was $1.6 million and $3.1 million during the three months ended September 30, 2023 and 2022, respectively, related to commercial
supply revenue for KORSUVA injection sales to CSL Vifor.
Research and Development (R&D) Expenses:
R&D expenses were $25.5 million for the three months ended September 30, 2023 compared to $24.7 million in the same period
of 2022. The slightly higher R&D expenses in 2023 were primarily due to increases in clinical trial costs related to our three late-stage
development programs, partially offset by a decrease in stock-based compensation expense. R&D expenses for the three months ended
September 30, 2022 included $5.0 million related to a milestone payment due to Enteris Biopharma, Inc.
General and Administrative (G&A) Expenses:
G&A expenses were essentially flat at $6.8 million for the three months ended September 30, 2023 compared to $6.9 million
in the same period of 2022.
Other Income, net: Other income, net was
approximately $866,000 for the three months ended September 30, 2023 compared to approximately $665,000 in the same period of 2022.
The increase in other income, net was primarily due to an increase in interest income resulting from a higher yield on our portfolio
of investments during the three months ended September 30, 2023.
Financial Guidance
Cara expects that our current unrestricted cash
and cash equivalents and available-for-sale marketable securities, including the proceeds from our recently announced royalty financing
and the collaborative revenue from our share of the profit from KORSUVA injection, will be sufficient to fund our currently anticipated
operating plan into 2025.
About Cara Therapeutics
Cara Therapeutics is
a commercial-stage biopharmaceutical company leading a new treatment paradigm to improve the lives of patients suffering from pruritus.
The Company’s KORSUVA® (difelikefalin) injection is the first and only FDA-approved treatment for moderate-to-severe pruritus
associated with chronic kidney disease in adults undergoing hemodialysis. The Company is developing an oral formulation of difelikefalin
and has Phase 3 programs ongoing for the treatment of pruritus in patients with advanced chronic kidney disease and atopic dermatitis.
In addition, the Company has an ongoing Phase 2/3 program of oral difelikefalin for the treatment of moderate-to-severe pruritus in patients
with notalgia paresthetica. For more information, visit www.CaraTherapeutics.com and follow the company on X (Twitter),
LinkedIn and Instagram.
Forward-looking Statements
Statements contained in this press release regarding
matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation
Reform Act of 1995. Examples of these forward-looking statements include statements concerning the Company’s and its partners ongoing
commercialization of and ability to successfully commercialize KORSUVA injection and Kapruvia, future revenue and profit share from sales
of KORSUVA and Kapruvia, planned future regulatory submissions and potential future regulatory approvals, future product launches, the
performance of the Company’s commercial partners, including CSL Vifor, expected timing of the initiation, enrollment and data readouts
from the Company’s planned and ongoing clinical trials, the potential results of ongoing clinical trials, timing of future regulatory
and development milestones for the Company’s product candidates, the potential for the Company’s product candidates to be
alternatives in the therapeutic areas investigated and the potential for oral difelikefalin to address additional pruritic indications,
the size and growth of the potential markets for pruritus management, the receipt of potential milestone payments pursuant to the Purchase
and Sale Agreement with HealthCare Royalty and the Company’s expected cash reach. Because such statements are subject to risks
and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These risks
and uncertainties include the risks inherent in the launch of new products, including that our commercial partners, including CSL Vifor,
may not perform as expected, risks inherent in the clinical and regulatory development of pharmaceutical products, and the risks described
more fully in Cara Therapeutics’ filings with the Securities and Exchange Commission, including the “Risk Factors”
section of the Company’s Annual Report on Form 10-K for the year ending December 31, 2022 and its other documents subsequently
filed with or furnished to the Securities and Exchange Commission, including its Form 10-Q for the quarter ended September 30,
2023. All forward-looking statements contained in this press release speak only as of the date on which they were made. Cara Therapeutics
undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they
were made, except as required by law.
Financial tables follow
CARA THERAPEUTICS, INC. |
CONDENSED BALANCE SHEETS |
(in thousands) |
(unaudited) |
| |
September 30, | | |
December 31, | |
| |
2023 | | |
2022 | |
Assets | |
| | | |
| | |
Current assets: | |
| | | |
| | |
Cash and cash equivalents | |
$ | 62,875 | | |
$ | 63,741 | |
Marketable securities | |
| 15,666 | | |
| 81,658 | |
Accounts receivable, net - related party | |
| 3,351 | | |
| 3,260 | |
Inventory, net | |
| 3,266 | | |
| 2,383 | |
Income tax receivable | |
| 697 | | |
| 697 | |
Other receivables | |
| 1,682 | | |
| 496 | |
Prepaid expenses | |
| 12,658 | | |
| 16,267 | |
Restricted cash | |
| 408 | | |
| 408 | |
Total current assets | |
| 100,603 | | |
| 168,910 | |
Operating lease right-of-use assets | |
| 7,108 | | |
| 1,551 | |
Marketable securities, non-current | |
| 4,747 | | |
| 11,350 | |
Property and equipment, net | |
| 1,380 | | |
| 426 | |
Restricted cash, non-current | |
| 1,500 | | |
| - | |
Total assets | |
$ | 115,338 | | |
$ | 182,237 | |
| |
| | | |
| | |
Liabilities and stockholders’ equity | |
| | | |
| | |
Current liabilities: | |
| | | |
| | |
Accounts payable and accrued expenses | |
$ | 22,384 | | |
$ | 21,540 | |
Operating lease liabilities, current | |
| 497 | | |
| 1,918 | |
Total current liabilities | |
| 22,881 | | |
| 23,458 | |
| |
| | | |
| | |
Operating lease liabilities, non-current | |
| 6,815 | | |
| - | |
| |
| | | |
| | |
Commitments and contingencies | |
| - | | |
| - | |
| |
| | | |
| | |
Stockholders’ equity: | |
| | | |
| | |
Preferred stock | |
| - | | |
| - | |
Common stock | |
| 54 | | |
| 53 | |
Additional paid-in capital | |
| 738,435 | | |
| 726,630 | |
Accumulated deficit | |
| (652,408 | ) | |
| (566,232 | ) |
Accumulated other comprehensive loss | |
| (439 | ) | |
| (1,672 | ) |
Total stockholders’ equity | |
| 85,642 | | |
| 158,779 | |
Total liabilities and stockholders’ equity | |
$ | 115,338 | | |
$ | 182,237 | |
CARA
THERAPEUTICS, INC. |
CONDENSED STATEMENTS
OF OPERATIONS |
(amounts in thousands,
except share and per share data) |
(unaudited) |
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Revenue: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Collaborative revenue |
|
$ |
2,471 |
|
|
$ |
7,443 |
|
|
$ |
10,631 |
|
|
$ |
15,446 |
|
Commercial supply revenue |
|
|
1,252 |
|
|
|
3,370 |
|
|
|
5,843 |
|
|
|
8,160 |
|
Royalty revenue |
|
|
167 |
|
|
|
- |
|
|
|
415 |
|
|
|
- |
|
License and milestone fees |
|
|
910 |
|
|
|
- |
|
|
|
910 |
|
|
|
15,000 |
|
Clinical compound revenue |
|
|
66 |
|
|
|
- |
|
|
|
165 |
|
|
|
- |
|
Total revenue |
|
|
4,866 |
|
|
|
10,813 |
|
|
|
17,964 |
|
|
|
38,606 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cost of goods sold |
|
|
1,558 |
|
|
|
3,055 |
|
|
|
5,566 |
|
|
|
5,136 |
|
Research and development |
|
|
25,451 |
|
|
|
24,691 |
|
|
|
80,095 |
|
|
|
65,869 |
|
General and administrative |
|
|
6,755 |
|
|
|
6,912 |
|
|
|
21,191 |
|
|
|
23,829 |
|
Total operating expenses |
|
|
33,764 |
|
|
|
34,658 |
|
|
|
106,852 |
|
|
|
94,834 |
|
Operating loss |
|
|
(28,898 |
) |
|
|
(23,845 |
) |
|
|
(88,888 |
) |
|
|
(56,228 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other income, net |
|
|
866 |
|
|
|
665 |
|
|
|
2,712 |
|
|
|
1,093 |
|
Net loss |
|
$ |
(28,032 |
) |
|
$ |
(23,180 |
) |
|
$ |
(86,176 |
) |
|
$ |
(55,135 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss per share: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Basic and Diluted |
|
$ |
(0.52 |
) |
|
$ |
(0.43 |
) |
|
$ |
(1.59 |
) |
|
$ |
(1.03 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Weighted average shares: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Basic and Diluted |
|
|
54,235,695 |
|
|
|
53,726,123 |
|
|
|
54,038,239 |
|
|
|
53,616,753 |
|
MEDIA CONTACT:
Annie Spinetta
6 Degrees
973-768-2170
aspinetta@6degreespr.com
INVESTOR CONTACT:
Iris Francesconi, Ph.D.
Cara Therapeutics
203-406-3700
investor@caratherapeutics.com
v3.23.3
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