ST. LOUIS, July 19, 2011 /PRNewswire/ -- Sigma Life Science,
the innovative biological products and services research business
of Sigma-Aldrich Corporation (Nasdaq: SIAL) today announced the
launch of CompoZr Targeted Integration Kit – mRosa26, which can
precisely and rapidly integrate transgenes into the mouse genome at
the Rosa26 safe harbor locus. This kit follows the introduction of
the CompoZr Targeted Integration Kit – AAVS1, for transgene
integration in the human genome. For additional information on both
kits, visit sigma.com/targetedkit.
Traditional transgenic approaches rely on random integration of
a transgene. This low efficiency approach results in multiple
random integration events at off-target insertion sites, and often
requires the use of antibiotic selection strategies. In addition,
the integration event can involve multiple copies of the transgene.
Using the CompoZr ZFN technology, a single copy of a transgene can
be targeted and inserted in the Rosa26 locus, which is a
well-defined safe harbor site in the mouse genome. Sigma's CompoZr
Targeted Integration Kits use zinc finger nucleases (ZFNs) for
precise and heritable gene knockin at the target locus (Rosa26 or
AAVS1). Both Human and Mouse kits are supplied with the necessary
ZFNs and donor plasmid to successfully perform transgene
integration by ZFN-assisted homologous recombination, reducing the
timescale and complexity of engineering transgenic mouse and human
cell lines.
"ZFN mediated transgene integration using Sigma's CompoZr
Targeted Integration Kit – mRosa26 represents the most efficient
method for targeted transgene integration at the highly
characterized Rosa26 locus of the mouse genome," said Dr.
Supriya Shivakumar, Global
Commercial Marketing Manager for Functional Genomics at Sigma Life
Science. "This latest release is part of Sigma's ongoing objective
to increase the research community's access to advanced genomic
engineering strategies by offering innovative, easy-to-use products
based on our proprietary zinc finger nuclease technology."
Cautionary statement: The foregoing release contains
forward-looking statements that can be identified by terminology
such as "precisely and rapidly," "expected," "represents the most
efficient," or similar expressions, or by expressed or implied
discussions regarding potential future revenues from products
derived there from. You should not place undue reliance on these
statements. Such forward-looking statements reflect the current
views of management regarding future events, and involve known and
unknown risks, uncertainties and other factors that may cause
actual results to be materially different from any future results,
performance or achievements expressed or implied by such
statements. There can be no guarantee that CompoZr Targeted
Integration Kit – mRosa26 will assist the Company to achieve any
particular levels of revenue in the future. In particular,
management's expectations regarding products associated with that
CompoZr Targeted Integration Kit – mRosa26 could be affected by,
among other things, unexpected regulatory actions or delays or
government regulation generally; the Company's ability to obtain or
maintain patent or other proprietary intellectual property
protection; competition in general; government, industry and
general public pricing pressures; the impact that the foregoing
factors could have on the values attributed to the Company's assets
and liabilities as recorded in its consolidated balance sheet, and
other risks and factors referred to in Sigma-Aldrich's current Form
10-K on file with the US Securities and Exchange Commission. Should
one or more of these risks or uncertainties materialize, or should
underlying assumptions prove incorrect, actual results may vary
materially from those anticipated, believed, estimated or expected.
Sigma-Aldrich is providing the
information in this press release as of this date and does not
undertake any obligation to update any forward-looking statements
contained in this press release as a result of new information,
future events or otherwise.
About Sigma Life Science: Sigma Life Science is a
Sigma-Aldrich business that represents the Company's leadership in
innovative biological products and services for the global life
science market and offers an array of biologically rich products
and reagents that researchers use in scientific investigation.
Product areas include biomolecules, genomics and functional
genomics, cells and cell-based assays, transgenics, protein assays,
stem cell research, epigenetics and custom
services/oligonucleotides. Sigma Life Science also provides an
extensive range of critical bioessentials like biochemicals,
antibiotics, buffers, carbohydrates, enzymes, forensic tools,
hematology and histology, nucleotides, amino acids and their
derivatives, and cell culture media.
About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High
Technology company committed to Enabling Science to Improve the
Quality of Life. Its chemical and biochemical products and kits are
used in scientific research, including genomic and proteomic
research, biotechnology, pharmaceutical development and as key
components in pharmaceutical, diagnostic and other high technology
manufacturing. The Company has customers in life science companies,
university and government institutions, hospitals, and in industry.
Over one million scientists and technologists use its products.
Sigma-Aldrich operates in 40
countries and has 8,000 employees providing excellent service
worldwide. For more information about Sigma-Aldrich, please visit
its award-winning Web site at http://www.sigma-aldrich.com.
Sigma-Aldrich, Sigma and
CompoZr are registered trademarks of Sigma-Aldrich Co LLC.
SOURCE Sigma-Aldrich