PharmaGap Sets Time for in Vivo Tests
October 27 2011 - 8:00AM
Marketwired
PharmaGap Inc. (TSX VENTURE:GAP)(OTCBB:PHRGF)("PharmaGap" or "the
Company") reported today that in vivo ("in life") efficacy testing
of its GAP-107B8 cancer drug, in original, enhanced and liposome
formulated versions, is scheduled to begin on or about November 13,
2011. In this efficacy study, the PharmaGap drug compounds will be
tested in validated mouse models for ovarian cancer, using 3 human
ovarian cancer cell lines across a total of 168 mice including
treated and control groups. The treatment periods for the three
cell lines will be staggered, and will run through the third week
of December.
Prior to this, the Company will undertake a Maximum Tolerated
Dose ("MTD") study in order to finalize the dose level range for
the efficacy study. The MTD study will evaluate the tolerability of
PharmaGap's formulations in a repeat dosing design suitable for use
in efficacy models and is scheduled to begin on October 28.
Following the treatment period, compilation of all data,
including in-life observations along with histology and pathology
examination observations will be analyzed in order to inform the
Company as to the preferred formulation of GAP-107B8 with which to
proceed to clinical trials.
While this test program is undertaken, the Company is proceeding
aggressively in discussions with candidates for its cGMP ("current
Good Manufacturing Practices) manufacturing development program,
and with clinical trial contract research organizations for
development (and eventual delivery) of protocols for PharmaGap's
first clinical trial. These three elements (in vivo efficacy
results, manufacturing, and clinical trial protocol) will converge
to provide the basis to undertake the required GLP (Good Laboratory
Practices") Toxicology program using cGMP grade material, and to
the continued generation and compilation of all data required for
inclusion in its clinical trial application.
About PharmaGap Inc.
PharmaGap Inc. (TSX VENTURE:GAP), based in Ottawa, ON, is a
biotechnology company with a core focus on developing novel peptide
therapeutics for the treatment of cancer. PharmaGap's GAP-107B8 is
a novel peptide drug that has been shown to be highly cytotoxic to
numerous cancer types, including chemo-resistant cancers, in vitro.
For more information on PharmaGap please visit the Company's
website at www.pharmagap.com.
Forward Looking Statements
This news release contains certain statements that constitute
forward-looking statements as they relate to the Company and its
management. Forward-looking statements are not historical facts but
represent management's current expectations of future events, and
can be identified by words such as "believe", "expects", "will",
"intends", "plans", "projects", "anticipates", "estimates",
"continues", and similar expressions. Although management believes
that expectations represented in such forward-looking statements
are reasonable, there can be no assurance that they will prove to
be correct.
By their nature, forward-looking statements include assumptions
and are subject to inherent risks and uncertainties that could
cause actual future results, conditions, actions or events to
differ materially from those in the forward-looking statements. If
and when forward-looking statements are set out in this news
release, PharmaGap will also set out the material risk factors or
assumptions used to develop the forward-looking statements. Except
as expressly required by applicable securities laws, the Company
assumes no obligation to update or revise any forward-looking
statements. The future outcomes that relate to forward-looking
statements may be influenced by many factors, including, but not
limited to: results of ongoing product testing and development;
regulatory approvals required to complete development of products;
ability to manufacture product at quality and scale for human use
on an economically sound basis; patient reimbursement by private
and public health insurance programs; unintended side effects of
products; competitive products; product liability; intellectual
property; reliance on key personnel; risks of future legal
proceedings; income tax matters; availability and terms of
financing; distribution of securities; effect of market interest
rates on price of securities, and potential dilution.
Note: Neither the TSX Venture Exchange nor its Regulation
Services Provider (as that term is defined in the policies of the
TSX Venture Exchange) accepts responsibility for the adequacy or
accuracy of this release. No Securities Commission or other
regulatory authority having jurisdiction over PharmaGap has
approved or disapproved of the information contained herein. This
release contains forward looking statements that may not occur or
may change materially.
Contacts: PharmaGap Inc. Robert McInnis President & CEO
613-990-9551bmcinnis@pharmagap.com
Pharmagap Inc. (TSXV:GAP)
Historical Stock Chart
From May 2024 to Jun 2024
Pharmagap Inc. (TSXV:GAP)
Historical Stock Chart
From Jun 2023 to Jun 2024