Waters Introduces Faster, Reliable and Automated Solution for Mass and Purity Analysis of Biomolecules
March 22 2022 - 8:00AM
Business Wire
News Summary:
- New Intact Mass software application on waters_connect enables
simplified and significantly faster analysis of biomolecules for
mass and purity
- Intact Mass App is now available as an upgrade for new and
installed BioAccord LC-MS systems
- New line of Waters MaxPeak Premier columns further enhances the
analysis by delivering 2x to 3x greater sensitivity than
conventional steel columns
Waters Corporation (NYSE:WAT) today introduced new software and
analytical columns to aid biomolecule drug discovery and
development. The new Waters™ Intact Mass app on waters_connect™
allows scientists using the BioAccord™ LC-MS System to confirm the
mass of biomolecules and impurities made by synthetic or
recombinant processes nearly twice as fast as other commercially
available options.i
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Intact mass analysis on the Waters
BioAccord LC-MS System gives bioprocess engineers key information
about drug and process quality within minutes. (Photo: Business
Wire)
“Acquiring mass and purity data of biomolecules is time
consuming. Skilled analysis of complex mass spectrometry data is
required, typically in remote specialist analytical laboratories,”
said Jon Pratt, Waters Division Senior Vice President, Waters
Corporation. “The new Waters Intact Mass App enables bioengineers
and biochemists to accelerate drug discovery and development with
simplified technology to generate mass confirmation data on their
own in minutes/hours instead of days/weeks.”
Intact mass analysis is routinely performed during all stages of
the development of biological drugs including proteins, peptides,
oligonucleotide therapies and conjugates. In early stages of drug
discovery, biochemists must analyze hundreds or even thousands of
different samples per week. To help speed this process, the Waters
Intact Mass app provides a fast, reliable, and automated solution
to facilitate mass confirmation and purity determination of novel
biotherapeutics. The application features intelligent automated
deconvolution to process sample results within minutes of their
capture, with minimal user input.
Introducing Waters MaxPeak Premier Protein BEH C4 300Å
Columns for Intact & Subunit Protein Analyses
Complementing the introduction of the Intact Mass app is a new
line of analytical columns that are essential for analyzing intact
biomolecules and their subunits. The ACQUITY™ Premier and XBridge™
Premier Protein BEH C4 300Å Columns for the BioAccord LC-MS System
feature MaxPeak High Performance Surfaces (HPS) technology that
prevents the loss of sample analytes due to adsorption of
phosphorylated and carboxylated molecules between the sample and
metal surfaces of both the LC system and column. This enables up to
3X greater sensitivity for low-level intact mass analysis and 2X
greater sensitivity for the intact mass analysis of phosphorylated
proteins and low-level subunits of monoclonal antibodies.ii
The Intact Mass App on waters_connect is available for new
BioAccord LC-MS Systems and as an upgrade to previously installed
systems. MaxPeak Premier Protein BEH C4 300Å Columns are now
available from Waters worldwide.
Additional Resources
- Read the blog post: Automating Intact Mass Deconvolution: It’s
About Time
- See our application note: Intact Mass – A Versatile
waters_connect Application for Rapid Mass Confirmation and Purity
Assessment of Biotherapeutics
- Follow and connect with Waters via LinkedIn, Twitter, and
Facebook
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE:WAT), a global leader in analytical
instruments and software, has pioneered chromatography, mass
spectrometry, and thermal analysis innovations serving the life,
materials, and food sciences for more than 60 years. With more than
7,800 employees worldwide, Waters operates directly in more than 35
countries, including 14 manufacturing facilities, and with products
available in more than 100 countries.
Waters, BioAccord, ACQUITY, Premier, UPLC, XBridge, MaxPeak, and
waters_connect are trademarks of Waters Corporation.
_____________________ i Estimate based on obtaining the results
for 96 samples using a Waters BioAccord System and Intact Mass
parallel acquisition and processing approach as compared to the
“acquire then process” workflow of commercially available
offerings.
ii Based on a comparison of MaxPeak Premier Protein BEH C4 300Å
Columns with stainless steel ACQUITY Protein 300Å Columns
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version on businesswire.com: https://www.businesswire.com/news/home/20220322005136/en/
Brian J. Murphy PR Manager, Corporate Communications Waters
Corporation brian_j_murphy@waters.com +1 508-482-2614
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