Office Depot Inc. said its fourth-quarter earnings loss widened sharply on expenses related to its recent merger with OfficeMax Inc. and other items, as well as weaker margins.

The company in November completed its merger with rival OfficeMax Inc. in a deal initially valued at $1.2 billion.

In addition to integration challenges, the new Office Depot also must tackle broader industry challenges such as heightened competition from online sellers and a shift in the use of office technology that has put pressure on sales.

The latest quarterly results include OfficeMax's operations since the closing of the merger on Nov. 5, which generated $939 million of sales.

"With our leadership team now in place, we have moved quickly to establish a lean organizational structure with the best talent from across the legacy businesses as well as adding new external leadership," Chairman and Chief Executive Roland Smith said.

"We expect to complete a comprehensive reorganization of the company by the end of February 2014," Mr. Smith said.

The company increased its cost-savings estimate related to the merger to more than $600 million by the end of 2016.

Office Depot reported a loss of $120 million, or 34 cents a share, compared with a year-earlier loss of $7 million, or six cents a share. Excluding merger-related expenses, asset write-downs and other items, the adjusted loss was three cents, compared with year-earlier adjusted break-even results.

Total sales increased 33% to $3.49 billion but fell 2.9% excluding contributions from OfficeMax.

Analysts polled by Thomson Reuters expected revenue of $4.03 billion.

Write to Tess Stynes at tess.stynes@wsj.com

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