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Pfizer Inc. (PFE) posted a 2% drop in first-quarter net income, reflecting a stronger dollar, increased generic competition and lower sales of its star drug, cholesterol-fighter Lipitor.

The world's largest drug maker by sales also said its acquisition of rival Wyeth remains on track.

Pfizer's Wyeth acquisition, announced in January, and a deal to combine its HIV-drug businesses with GlaxoSmithKline PLC (GSK.LN), show the lengths to which drug companies are going in search of sales growth as many of their biggest products lose steam. The pharmaceutical industry is trying to cope with a revenue decline from patented products and difficulties developing new drugs.

Pfizer reported net income of $2.73 billion, or 40 cents a share, down from $2.78 billion, or 41 cents a share, a year earlier. Excluding items, including a tax rate increase and costs related to the Wyeth deal in the latest quarter, and an increased tax cost a year earlier, earnings fell to 54 cents a share from 61 cents.

Revenue fell 8.3% to $10.87 billion, with the stronger dollar contributing 5 percentage points of the decline.

Analysts polled by Thomson Reuters were expecting earnings, excluding items, of 49 cents a share, on revenue of $11.08 billion.

Shares were up 2% to $13.78 in recent premarket trading.

The stronger dollar is of special concern to Pfizer, which gets 54% of total revenue abroad. International revenue dropped 7%, reflecting a 10 percentage point hit from the dollar. U.S. revenue dropped 10%.

Gross margin rose to 87% from 83.2%.

Pfizer is under more intense competition from generic versions of such products as chemotherapy treatment Camptosar, which recently lost patent protection. Cholesterol-fighter Lipitor, which goes off patent in 2011, remains Pfizer's best-selling product.

Pharmaceutical sales dropped 7%. Sales were hurt by the loss of U.S. exclusivity for Zyrtec in January 2008 and Camptosar in February 2008.

Lipitor sales fell 13%, hurt by continued intense competition, while arthritis drug Celebrex saw an 8% sales drop.

It lowered its forecast for reported 2009 earnings, including Wyeth-related transaction and financing costs, to $1.20 to $1.35 a share, from $1.34 to $1.49 a share. It still expects earnings, excluding items, of $1.85 to $1.95 a share. In January, it forecast that the stronger dollar would reduce 2009 revenue by $3 billion from a year ago.

Signs of pharmaceutical sales weakness were evident in first-quarter financial reports issued by GlaxoSmithKline PLC (GSK), Johnson & Johnson (JNJ), Abbott Laboratories (ABT), Merck & Co. (MRK) and Schering-Plough Corp. (SGP).

-By Mike Barris, Dow Jones Newswires; 201-938-5658; mike.barris@dowjones.com