Medgenics, Inc.
                         ('Medgenics' or the 'Company')
                                        
17 December 2008

Medgenics is pleased to announce that it is implementing a warrant repricing
programme (the "Programme" or "Transaction") to encourage the exercise of existing 
warrants provided that such exercise is completed by 30 January 2009.  The Programme, 
which allows existing warrant holders to exercise warrants on advantageous terms, 
follows on from the Company's announcement of positive key early results from its 
Phase I/II Clinical Trial of EPODURE as presented at a major medical congress in 
November 2008. This Programme aims to strengthen the Company's cash position to 
support its operations and its business development activities while increasing the 
share base and reducing the number of outstanding warrants.

To encourage existing warrant holders to exercise their warrants for cash before
30 January 2009, the following terms will be offered:

1.   Reduced Exercise Price :  $0.0375/share (2.5 pence/share)  or the current
     exercise price, whichever is lower; and
     
2.   Bonus Warrants:  for every one dollar ($1.00) or 0.667 GBP paid for
     exercise of warrants during this program, a new bonus warrant to purchase three
     (3) shares of common stock in the Company of $0.0001 par value per share
     ("Common Shares"), which will be immediately exercisable for three (3) years at
     an exercise price $0.25 per share, will be issued. For example, a total
     exercise price of $10,000 will result in a bonus warrant for 30,000 Common
     Shares at an exercise price of $0.25 per share.

The exercise price of any warrants that are not exercised before 30 January 2009 will
revert to the original price as stated in the warrant prior to this incentive programme.

The current warrants outstanding in the Company are as follows:

Warrant      Date of       No. of    Exercise     Expiry Date
Type           Issue       Common   Price per
                           Shares      Common
                                        Share
RS          31.03.06   15,680,818   US $0.0005       31.03.11
RS          31.03.06   36,481,902   US $0.071        31.03.11
RW          31.03.06    1,609,325   US $0.000005     31.03.11
X           31.03.06    4,278,298   US $0.071        24.03.10
X            2.01.06      533,183   US $0.071         2.01.11
W           31.03.06   26,809,141   US $0.071        31.03.11
W           10.04.06    1,026,792   US $0.071        10.04.11
W           14.06.06    1,069,575   US $0.071        14.06.11
W           23.10.06   21,094,940   US $0.117        23.10.11
W            9.02.07      705,919   US $0.071        31.03.11
W           13.03.07    2,042,887   US $0.071        31.03.11
W           13.03.06    2,117,758   US $0.071        21.06.11
W           31.05.07    1,329,310   US $0.071        31.05.12
W           13.08.07      654,580   US $0.164        13.08.12
W           17.08.07      369,773   US $0.164        17.08.12
W            4.12.08    1,067,287   US $0.164         4.12.12
W            4.12.08      192,523         7.8p        4.12.12
W            4.12.08    6,563,398   US $0.194         4.12.12
W            4.12.08      458,308        9.22p        4.12.12
W            4.12.08      570,992          10p        4.12.12
Platinum    13.03.07    1,909,619   US $0.164        31.03.11
Platinum     4.12.08    1,604,362   US $0.164         4.12.12
Platinum     4.12.08       23,183         10p         4.12.12

Total                 128,193,873                            
                         
The current number and details of warrants held (both directly and indirectly)
by the Directors are as follows:

Name       Warrant  Number   Issue   Expiry  Exercise  Discount  Discount Discount
            name             date    date    price     price     per      US$
                                             US$       US$       warrant
                                                                 US$
                                                        
Lord Leonard  W   4,832,423  4/12/07  4/12/12  0.194     0.0375    0.1565   756,274
Steinberg     W   1,145,964  31/5/12  31/5/07  0.164     0.0375    0.1265   144,525
              W     763,997  4/12/07  4/12/12  0.164     0.0375    0.1265    96,646
           ------------------------------------------------------------------------
                  6,742,384                                                 997,445
                                                              
                                                                  
Andrew       RS  31,681,652  31/3/06  31/3/11  0.071     0.0375    0.0335 1,057,195
Pearlman     RW   1,260,451  31/3/06  31/3/11  0.000005  0.0375      0.00         -
           ------------------------------------------------------------------------
                 32,942,103                                               1,057,195
                                                            
Joel          W   7,059,192  31/3/06  31/3/11  0.071     0.0375    0.0335   235,560
Kanter        W   1,069,575 23/10/06 23/10/11  0.117     0.0375    0.0795    84,891
              W     857,007 23/10/06 23/10/11  0.117     0.0375    0.0795    68,020
             RW     197,914  31/3/06  31/3/11  0.000005  0.0375      0.00         -
             RS  14,080,734  31/3/06  31/3/11  0.023634  0.0375      0.00         -
           ------------------------------------------------------------------------
                 23,264,422                                                 388,471
                                                             
                                                                 
Gary Brukardt W   2,117,758  13/3/06  13/3/11  0.071     0.0375    0.0335    70,668
                                          
Stephen       W   1,069,575  14/6/06  14/6/11  0.071     0.0375    0.0335    35,691
McMurray                                          
                                                                 
Eugene       RS   3,000,156  31/3/06  31/3/11  0.071     0.0375    0.0335   100,505
Bauer                                                   
           ------------------------------------------------------------------------
Total            66,136,241                                               2,549,469
           ========================================================================

Joel Kanter and Lord Leonard Steinberg have stated that, as a result of this incentive
programme, they will exercise warrants at the reduced exercise price of $0.0375
to an aggregate value of US$150,000 each. The remaining directors (the "Independent 
Directors") have decided not to exercise their warrants as a result of the Programme 
so that they are able to remain independent in their assessment of whether the 
Transaction is in the interest of all shareholders of the Company.

In view of the interests and intended exercise of warrants at the reduced price
by Joel Kanter and Lord Leonard Steinberg, this Transaction is deemed to be a related 
party transaction under the AIM rules and therefore Joel Kanter and Lord Leonard 
Steinberg are precluded, in accordance with the AIM rules, from expressing an opinion 
that the Transaction is fair and reasonable insofar as the shareholders are concerned.

The Independent Directors consider, having consulted with Blomfield Corporate 
Finance Limited, the Company's nominated adviser, that the terms of the Transaction are 
fair and reasonable insofar as the Company's shareholders are concerned.

The Independent Directors make this assessment based on the rationale for the
Programme and in particular the Company's cash flow requirements, the
current share price and lack of availability at this time of alternative viable
short-term fund-raising methods especially given the current economic climate.

The Company anticipates that the exercise of warrants between this announcement
and 30 January 2009 will have a positive impact on the Company, both in terms of cash 
flow and in reducing the total number of outstanding warrants.

Warrant holders will be required to execute certain documents and make certain
representations in order to participate in the warrant repricing program.
Further details regarding the program and the procedures to exercise the
warrants have been posted to Warrant Holders and are also available on the
Company's website (www.medgenics.com).

On 13 November 2008, 18,271,007 Common Shares which are no longer subject to
restrictions on transfer under the US Securities Act began trading under the
ISIN US58436Q1040 and the TIDM (ticker) MEDU. These unrestricted securities may
generally be sold to any purchaser, regardless of their nationality and is
capable of being held and transferred within CREST.

The Company is pleased to announce that, further to the announcement on 12
November 2008, the application for these shares Common Shares to be settled
within CREST was formally submitted to Euroclear on 9 December 2008 and CREST
settlement is expected to be enabled on Thursday 18 December 2008.

The  Common  Shares will not themselves be admitted to CREST  but,  instead, a
depository  service provider approved by the Company will issue depository
interests ("DIs") representing the  underlying unrestricted Common Shares, which
will be transferred to the  DI provider  and held on trust for the holders of
the DIs. The DIs themselves are independent securities constituted under
English law, which may be held and transferred within the CREST system. CREST
is a voluntary system and holders of unrestricted Common Shares who wish to
retain share certificates shall be able to do so.


For further information, contact:

Medgenics, Inc.                                               Phone: +972 4 902 8900
Dr. Andrew L. Pearlman                     

Grayling Global (Financial PR, UK)                            Phone: +44 207 255 5406
Jonathan Shillington                                          jonathan.shillington@uk.grayling.com
Alistair Scott                             

Blomfield Corporate Finance Limited (Nominated Adviser)       Phone: +44 207 489 4500
James Pinner
Alan MacKenzie

SVS Securities plc (Broker)                                   Phone: +44 207 638 5600
Peter Manfield                             
Ian Callaway

United States contacts:                    
                                           
Grayling Global (Investor Relations)                          Phone: +1 646 284 8472
Leslie Wolf-Creutzfeldt                                       lwolf-creutzfeldt@hfgcg.com
                                           
                                           
Grayling Global (Media Relations)                             Phone: +1 646 284 9455
Ivette Almeida                                                ialmeida@hfgcg.com

NOTES TO EDITORS:

Medgenics, Inc. is a clinical-stage biopharmaceutical company  developing  its
unique  tissue-based  Biopump  platform technology to  provide  sustained-action
protein therapy for the treatment of a range of chronic diseases.

Medgenics currently has two products in development based on this technology:

*    EPODURE - producing erythropoietin (EPO) to treat anemia
*    INFRADURE - producing interferon-alpha (IFN-a) to treat hepatitis C

The  Company  has  demonstrated  proof of principle  of  the  Biopump  treatment
procedure in a clinical trial using a short-acting version of EPODURE in  anemic
subjects.  The  Company announced positive initial results  in  its  Phase  I/II
clinical  trial for its long-acting version of EPODURE, designed to produce  and
deliver  a  therapeutic dose of EPO steadily for three to six  months  or  more,
which  commenced  in August 2008. The Company plans to follow  with  a  clinical
trial of INFRADURE in 2009.

Medgenics  intends to develop its innovative products and bring them  to  market
via  multiple  strategic partnerships with major pharmaceutical  and/or  medical
device companies, starting with EPODURE and INFRADURE.

Beyond these, Medgenics plans to develop and/or out-license a pipeline of future
Biopump  products targeting the large and rapidly growing global protein therapy
market, which is forecast to reach US $87 billion by 2010. Other potential areas
include multiple sclerosis (interferon-a), haemophilia (Factor XIII), paediatric
growth hormone deficiency (human growth hormone) and diabetes (insulin).

Founded in 2000, Medgenics is a US-incorporated company with major operations in
Misgav,  Israel.  Medgenics was admitted to AIM in December 2007  and  currently
trades  under  two  separate  lines  on the AIM  market;  the  Reg.S  restricted
securities  trade  under  the TIDM (AIM: MEDG) and the  unrestricted  securities
trade under the TIDM (AIM:MEDU).

www.medgenics.com

CAUTIONARY NOTICE REGARDING FORWARD-LOOKING STATEMENTS
This  release contains forward-looking statements, which include all  statements
other  than statements of historical fact, including (without limitation)  those
regarding  the  Company's  financial  position,  business  strategy,  plans  and
objectives  of  management  for future operations. These  statements  relate  to
future   events,   prospects,   developments  and  strategies.   Forward-looking
statements  are sometimes identified by their use of the terms and phrases  such
as "estimate," "project," "intend," "forecast," "anticipate," "plan," "planning,
"expect," "believe," "will," "will likely," "should," "could," "would," "may" or
the  negative of such terms and other comparable terminology. All such  forward-
looking  statements are based on current expectations and are subject  to  risks
and  uncertainties. Should any of these risks or uncertainties  materialize,  or
should  any  of  the Company's assumptions prove incorrect, actual  results  may
differ  materially from those included within these forward-looking  statements.
Accordingly,  no  undue  reliance  should be  placed  on  these  forward-looking
statements,  which  speak  only  as  of the date  made.  The  Company  expressly
disclaims  any obligation or undertaking to disseminate any updates or revisions
to  any forward-looking statements contained herein to reflect any change in the
Company's  expectations with regard thereto or any change in events,  conditions
or  circumstances on which any such statements are based. As a result  of  these
factors,  the  events described in the forward-looking statements  contained  in
this release may not occur.


-END-


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