TIDMBNR

RNS Number : 5568G

Burning Rock Biotech Limited

16 November 2022

B urning R ock Reports Third Quarter 2022 Financial Results

GUANGZHOU, China, November 16, 2022-Burning Rock Biotech Limited (NASDAQ: BNR and LSE: BNR , the "Company" or "Burning Rock"), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months ended September 30, 2022.

Recent Business Updates

   --         Corporate 

o Listed on the Main Market of the London Stock Exchange (the "LSE") by way of a direct listing on November 1, 2022, while Burning Rock's ADSs will continue to be listed and traded on the Nasdaq Global Market, with those ADSs being fully fungible with the ADSs listed on the LSE.

   --         Therapy Selection and Minimal Residual Disease (MRD) 

o In-hospital strategy continues to drive growth uplift despite negative Covid impact. In-hospital volumes grew 24% year-over-year in the third quarter of 2022.

o MRD volumes continue to ramp up following commercial launch in March 2022, with approximately 700 tests completed in the third quarter of 2022, more than doubling the volumes in the second quarter of 2022.

   --        Early Detection 

o PROMISE study (2,035 participants) for 9-cancer test results presented at European Society for Medical Oncology (ESMO) Congress 2022 in September 2022. Overall sensitivity achieved 83.7% for 9 cancers at specificity of 98.3%, with methylation contributing majority of positive detections compared to protein and mutation. Tissue origin prediction accuracy achieved 90.9% for the top 2 organs.

o Commercialization of our blood-based, 6-cancer early detection test gaining initial traction, with product onboarding completed at a few hospitals.

   --         Pharma Services 

o The total value of new contracts we entered into from January to September 2022 amounted to RMB198 million, representing approximately 38% increase from the same period of 2021.

o Starting to work with BeiGene on initial clinical studies using our personalized MRD test brPROPHET(TM) .

o New companion diagnostics (CDx) development announced with Eli Lilly and Company in China, for the RET inhibitor selpercatinib.

Third Quarter 2022 Financial Results

Revenues were RMB154.6 million (US$21.7 million) for the three months ended September 30, 2022, representing a 22.1% increase from RMB126.6 million for the same period in 2021.

-- Revenue generated from central laboratory business was RMB90.0 million (US$12.7 million) for the three months ended September 30, 2022 , representing a 14.2% increase from RMB78.8 million for the same period in 2021, driven by revenue increase from monitoring packages that consist of multiple tests per package.

-- Revenue generated from in-hospital business was RMB49.6 million (US$7.0 million) for the three months ended September 30, 2022, representing a 13.5% increase from RMB 43.7 million for the same period in 2021 , primarily attributable to in-hosiptal sales volume growth in Shanghai and Beijing as COVID impact lessened in the third quarter of 2022.

-- Revenue generated from pharma research and development services was RMB15.0 million (US$2.1 million) for the three months ended September 30, 2022, representing a 267.4% increase from RMB4.1 million for the same period in 2021, primarily attributable to increased development and testing services performed for our pharma customers.

Cost of revenues was RMB46.0 million (US$6.5 million) for the three months ended September 30, 2022 , representing a 31.5 % increase from RMB35.0 million for the same period in 2021, primarily due to an increase in testing and selling volume as well as rental expense and renovation depreciation in relation to our new laboratory that commenced use in January 2022.

Gross profit was RMB108.6 million (US$15.3 million) for the three months ended September 30, 2022 , representing a 18.6% increase from RMB91.6 million for the same period in 2021. Gross margin was 70.2% for the three months ended September 30, 2022, which decreased from 72.3% for the same period in 2021, primarily due to an increased income from monitoring packages, offset by an increased depreciation in relation to our new laboratory.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB117.0 million (US$16.4 million) for the three months ended September 30, 2022 , representing a 25.8% increase from RMB93.0 million for the same period in 2021. Non-GAAP gross margin was 75.7% for the three months ended September 30, 2022, compared to 73.4% for the same period in 2021.

Operating expenses were RMB343.2 million (US$48.3 million) for the three months ended September 30, 2022, representing a 30.7% increase from RMB 262.6 million for the same period in 2021 .

-- Research and development expenses were RMB109.4 million (US$15.4 million) for the three months ended September 30, 2022, representing a 57.2 % increase from RMB69.6 million for the same period in 2021, primarily due to (i) an increase in clinical program expenses for early cancer detection; and (ii) an increase in amortized expense on share-based compensation, offset in part by a decrease in staff cost due to organizational restructuring.

-- Selling and marketing expenses were RMB90.3 million (US$12.7 million) for the three months ended September 30, 2022, representing a 17.7% increase from RMB 76.7 million for the same period in 2021, primarily due to (i) an increase in staff cost resulted from increase in headcount; (ii) an increase in conference fee and (iii) an increase amortized expense on share-based compensation. Sequentially, selling and marketing expenses in the third quarter decreased by 14.5% compared to the second quarter of 2022, as our sales reorganization and operating efficiency improvement initiative started to generate initial results. We will continue to focus on improving operating efficiency going forward.

-- General and administrative expenses were RMB143.5 million (US$20.2 million) for the three months ended September 30, 2022, representing a 23.4% increase from RMB116.3 million for the same period in 2021, primarily due to (i) an increase in depreciation expenses for a new building; (ii) an increase in allowance for credit loss in relation to accounts receivables; and (iii) an increase amortized expense on share-based compensation.

Net loss was RMB231.5 million (US$32.5 million) for the three months ended September 30, 2022, compared to RMB170.5 million for the same period in 2021.

Net cash used in operating activities was RMB135.5 million (US$19.0 million) for the three months ended September 30, 2022, compared to RMB133.4 million for the same period in 2021. The balance of cash, cash equivalents, restricted cash and short-term investments was RMB1,014.0 million ( US$142.5 million) as of September 30 , 2022.

Revised 2022 Financial Guidance

We believe that we have achieved strong, above-industry growth in the first nine months of 2022, generating revenues of RMB421 million, an increase of 17% compared to the same period of 2021. This is below the implied full-year growth rate of our initial guidance at the beginning of the year, primarily due to an out-sized Covid impact in Shanghai in the second quarter and to a lesser extent, Covid-related disruptions in other regions of China from time to time. We have observed another significant wave of Covid cases sweeping through many large cities in China since the start of October, particularly in Guangzhou, which is one of our key markets and where our central lab is located. We are taking a cautious view now and project a drop in revenues in the fourth quarter compard to the same period last year, which was a strong quarter and relatively free of large Covid impacts. We therefore revise our 2022 full-year revenue guidance to a growth of approxiately 5% compared to 2021.

Transition of Chief Operating Officer to Chief Scientific Officer

Effective November 2022, Shannon Chuai, our chief operating officer, is taking on a new role of chief scientific officer of Burning Rock. In her new role, Shannon will lead key projects of our pipeline development, provide senior oversight on our early cancer detection clinical programs and our engagement on product registration with the NMPA and other medical regulatory bodies. Shannon continues to serve as a director on our board. The company's respective business units will report directly to our CEO, Yusheng Han.

Conference Call Information

Burning Rock will host a conference call to discuss the third quarter 2022 financial results at 8:30 a.m. U.S. Eastern Time (9:30 p.m. Hong Kong time) on November 16, 2022.

Please register in advance of the conference using the link provided below and dial in 15 minutes prior to the call, using participant dial-in numbers and unique registrant ID which would be provided upon registering.

PRE-REGISTER LINK: https://register.vevent.com/register/BI96c581babaf44021ab6c34af9f7ce42b .

Additionally, a live and archived webcast of the conference call will also be available on the company's investor relations website at http://ir.brbiotech.com or through link https://edge.media-server.com/mmc/p/8fj2edsi .

A replay of the webcast will be available for 12 months via the same link above.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR; LSE: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute "forward-looking" statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "target," "confident" and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock's beliefs and expectations, are forward-looking statements. Such statements are based upon management's current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock's control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP"). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company's ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: IR@brbiotech.com

Selected Operating Data

 
                                            For the three months ended 
                      -------  ---------------------------------------------------  ----------- 
                                           September    December    March     June    September 
                                  June     30, 2021       31,        31,      30,     30, 2022 
                                  30,                                2022     2022 
                        March                             2021 
                         31, 
                        2021      2021 
                      -------  --------  -----------  ----------  --------  ------  ----------- 
 Central Laboratory 
  Channel: 
 Number of patients 
  tested                7,716     8,155        7,808       8,235     7,743   8,060        7,989 
                                  1,013 
 
                                    300 
                      -------  --------  -----------  ----------  --------  ------  ----------- 
 Number of ordering 
  physicians(1)         1,082     1,013          920         917       994     767          897 
                      -------  --------  -----------  ----------  --------  ------  ----------- 
 Number of ordering 
  hospitals(2)            303       300          287         306       318     264          257 
                      -------  --------  -----------  ----------  --------  ------  ----------- 
 
 
(1)  Represents physicians who on average order at least one test from us every month during a 
      relevant period in the central laboratory channel. 
(2)  Represents hospitals whose residing physicians who on average order at least one test from 
      us every month during a relevant period in the central laboratory channel.                                               A s of 
                      -------  -------------------------------------------------  ----------- 
                                          September    December    March    June    September 
                                 June     30, 2021       31,        31,     30,        30, 
                                  30,                              2022     2022      2022 
                        March                            2021 
                         31, 
                        2021      2021 
                      -------  -------  -----------  ----------  -------  ------  ----------- 
       In-hospital 
       Channel: 
       Pipeline 
        partner 
        hospitals(1)       22       22           24          23       24      25           22 
                      -------  -------  -----------  ----------  -------  ------  ----------- 
       Contracted 
        partner 
        hospitals(2)       32       34           34          41       41      43           47 
                      -------  -------  -----------  ----------  -------  ------  ----------- 
       Total number 
        of 
        partner 
        hospitals          54       56           58          64       65      68           69 
                      -------  -------  -----------  ----------  -------  ------  ----------- 
(1)  Refers to hospitals that are in the process of establishing in-hospital laboratories, laboratory 
      equipment procurement or installation, staff training or pilot testing using the Company's 
      products. 
(2)  Refers to hospitals that have entered into contracts to purchase the Company's products for 
      use on a recurring basis in their respective in-hospital laboratories the Company helped them 
      establish. Kit revenue is generated from contracted hospitals. 
 

Selected Financial Data

 
                                                For the three months ended 
                        --------  ------------------------------------------------------  ----------- 
                                              September    December    March      June      September 
                          March      June        30,                    31,        30,      30, 2022 
                           31 ,      30,        2021                    2022      2022 
                                                              31, 
  Revenues                 2021      2021                    2021 
                        --------  --------  -----------  ----------  --------  ---------  ----------- 
                                                      (RMB in thousands) 
 Central laboratory 
  channel                 74,561    79,999       78,817      85,976    74,211     78,597       89,992 
                        --------  --------  -----------  ----------  --------  ---------  ----------- 
                                                                         48 , 
 In-hospital channel      28,994    40,502       43,714      51,906       957     34,177       49,636 
                        --------  --------  -----------  ----------  --------  ---------  ----------- 
 Pharma research and 
  development channel      3,068     6,778        4,084       9,463    12,356     18,072       15,003 
                        --------  --------  -----------  ----------  --------  ---------  ----------- 
 Total revenues          106,623   127,279      126,615     147,345   135,524    130,846      154,631 
                        --------  --------  -----------  ----------  --------  ---------  ----------- 
 
 
                                              For the three months ended 
                        -------  ---------------------------------------------------  ----------- 
                                            September    December    March     June     September 
                          March    June        30,         31,        31,       30,        30, 
                          31 ,      30,       2021                    2022     2022       2022 
  Gross profit             2021     2021                   2021 
                        -------  -------  -----------  ----------  --------  -------  ----------- 
                                                    (RMB in thousands) 
 Central laboratory 
  channel                55,212   58,681       58,387      65,985    50,574   57,575       69,991 
                        -------  -------  -----------  ----------  --------  -------  ----------- 
 In-hospital channel     20,070   29,426       31,111      34,194    33,396   20,012       31,593 
                        -------  -------  -----------  ----------  --------  -------  ----------- 
 Pharma research and 
  development channel     1,658    2,124        2,098       5,200     3,610    5,015        7,010 
                        -------  -------  -----------  ----------  --------  -------  ----------- 
 Total gross profit      76,940   90,231       91,596     105,379    87,580   82,602      108,594 
                        -------  -------  -----------  ----------  --------  -------  ----------- 
 
 
 
 
 
                                                    For the three months ended 
                              -------  ----------------------------------------------------  ----------- 
                                                  September    December    March      June     September 
                                March    June        30,         31,        31,       30,      30, 2022 
                                31 ,      30,       2021                    2022      2022 
  Share-based compensation                                       2021 
  expenses                       2021     2021 
                              -------  -------  -----------  ----------  --------  --------  ----------- 
                                                          (RMB in thousands) 
 Cost of revenues                 339      406          267         492       365       441          481 
                              -------  -------  -----------  ----------  --------  --------  ----------- 
 Research and development 
  expenses                     22,404   20,825      (9,559)     (4,033)    12,299    11,923       13,978 
                              -------  -------  -----------  ----------  --------  --------  ----------- 
 Selling and marketing 
  expenses                      2,633    2,809        2,044       2,126     1,774     2,158        2,346 
                              -------  -------  -----------  ----------  --------  --------  ----------- 
 General and administrative 
  expenses                     59,382   59,369       60,803      62,126    65,715    62,615       61,041 
                              -------  -------  -----------  ----------  --------  --------  ----------- 
 Total share-based 
  compensation expenses        84,758   83,409       53,555      60,711    80,153    77,137       77,846 
                              -------  -------  -----------  ----------  --------  --------  ----------- 
 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)

 
                                                  For the three months ended 
                  ------------------------------------------------------------------------------------------ 
                                                                                                                September 
                      March        June                    December                                                30, 
                      31 ,          30,                       31,                                                  2022 
                                                                          March        June       September 
                                              September                    31,          30,          30, 
                       2021         2021      30, 2021        2021        2022         2022          2022 
                  -----------  -----------  -----------  -----------  -----------  -----------  ------------  ------------ 
                      RMB          RMB          RMB          RMB          RMB          RMB           RMB           US$ 
 Revenues             106,623      127,279      126,615      147,345      135,524      130,846       154,631        21,738 
 Cost of                                                                              ( 48,244 
  revenues           (29,683)     (37,048)     (35,019)     (41,966)     (47,944)            )      (46,037)       (6,471) 
                  -----------  -----------  -----------  -----------  -----------  -----------  ------------  ------------ 
 Gross profit          76,940       90,231       91,596      105,379       87,580       82,602       108,594        15,267 
 Operating 
 expenses: 
 Research and 
  development 
  expenses           (77,414)    (108,071)     (69,649)    (112,724)    (119,496)     (92,112)     (109,433)      (15,384) 
 Selling and 
  marketing 
  expenses           (55,130)     (68,058)     (76,687)    (103,221)     (89,211)    (105,634)      (90,275)      (12,691) 
 General and 
  administrative 
  expenses          (116,259)    (116,130)    (116,304)    (141,563)    (141,733)    (150,316)     (143,530)      (20,177) 
 Total operating 
  expenses          (248,803)    (292,259)    (262,640)    (357,508)    (350,440)    (348,062)     (343,238)      (48,252) 
 Loss from 
  operations        (171,863)    (202,028)    (171,044)    (252,129)    (262,860)    (265,460)     (234,644)      (32,985) 
 Interest income          787          681          958        1,031        1,832        2,685         2,001           281 
 Interest 
  expenses              (510)        (565)        (367)         (94)          119         (29)            12             2 
 Other income 
  (expense), 
  net                     118          433           20        (372)          298          127         (189)          (27) 
 Foreign 
  exchange 
  gain (loss), 
  net                      57        (560)          380        (731)        (777)          624         1,337           188 
 Loss before 
  income 
  tax               (171,411)    (202,039)    (170,053)    (252,295)    (261,388)    (262,053)     (231,483)      (32,541) 
 Income tax 
  (expenses) 
  benefits                  -      (1,626)        (424)        1,151            -         (84)             -             - 
                  -----------  -----------  -----------  -----------  -----------  -----------  ------------  ------------ 
 Net loss           (171,411)    (203,665)    (170,477)    (251,144)    (261,388)    (262,137)     (231,483)      (32,541) 
                  ===========  ===========  ===========  ===========  ===========  ===========  ============  ============ 
 Net loss 
  attributable 
  to Burning 
  Rock 
  Biotech 
  Limited's 
  shareholders      (171,411)    (203,665)    (170,477)    (251,144)    (261,388)    (262,137)     (231,483)      (32,541) 
 Net loss 
  attributable 
  to ordinary 
  shareholders      (171,411)    (203,665)    (170,477)    (251,144)    (261,388)    (262,137)     (231,483)      (32,541) 
 Loss per share 
 for class A and 
 class B 
 ordinary 
 shares: 
 Class A 
  ordinary 
  shares - basic 
  and 
  diluted              (1.65)       (1.96)       (1.64)       (2.40)       (2.50)       (2.50)        (2.23)        (0.31) 
 Class B 
  ordinary 
  shares - basic 
  and 
  diluted              (1.65)       (1.96)       (1.64)       (2.40)       (2.50)       (2.50)        (2.23)        (0.31) 
 Weighted 
 average 
 shares 
 outstanding 
 used in loss 
 per 
 share 
 computation: 
 Class A 
  ordinary 
  shares - basic 
  and 
  diluted          86,721,263   86,764,260   86,908,975   87,128,297   87,179,752   87,532,539    86,585,322    86,585,322 
 Class B 
  ordinary 
  shares - basic 
  and 
  diluted          17,324,848   17,324,848   17,324,848   17,324,848   17,324,848   17,324,848    17,324,848    17,324,848 
 Other 
 comprehensive 
 income (loss), 
 net 
 of tax of nil: 
 Foreign 
  currency 
  translation 
  adjustments          14,080     (34,980)        6,146     (24,726)      (3,065)       29,715        20,646         2,902 
 Total 
  comprehensive 
  loss              (157,331)    (238,645)    (164,331)    (275,870)    (264,453)    (232,422)     (210,837)      (29,639) 
 Total 
  comprehensive 
  loss 
  attributable 
  to Burning 
  Rock 
  Biotech 
  Limited's 
  shareholders      (157,331)    (238,645)    (164,331)    (275,870)    (264,453)    (232,422)     (210,837)      (29,639) 
 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)

 
                                                    For the nine months ended 
                                            ---------------------------------------- 
                                              September     September     September 
                                                 30,           30,           30, 
                                                 2021          2022          2022 
                                            ------------  ------------  ------------ 
                                                 RMB           RMB           US$ 
 Revenues                                        360,517       421,001        59,183 
 Cost of revenues                              (101,750)     (142,225)      (19,993) 
                                            ------------  ------------  ------------ 
 Gross profit                                    258,767       278,776        39,190 
 Operating expenses: 
 Research and development expenses             (255,134)     (321,041)      (45,131) 
 Selling and marketing expenses                (199,875)     (285,120)      (40,082) 
 General and administrative expenses           (348,693)     (435,579)      (61,233) 
 Total operating expenses                      (803,702)   (1,041,740)     (146,446) 
 Loss from operations                          (544,935)     (762,964)     (107,256) 
 Interest income                                   2,426         6,518           916 
 Interest expenses                               (1,442)           102            14 
 Other income, net                                   571           236            33 
 Foreign exchange loss, net                        (123)         1,184           166 
 Loss before income tax                        (543,503)     (754,924)     (106,127) 
 Income tax expenses                             (2,050)          (84)          (12) 
                                            ------------  ------------  ------------ 
 Net loss                                      (545,553)     (755,008)     (106,139) 
                                            ============  ============  ============ 
 Net loss attributable to Burning 
  Rock Biotech Limited's shareholders          (545,553)     (755,008)     (106,139) 
 Net loss attributable to ordinary 
  shareholders                                 (545,553)     (755,008)     (106,139) 
 Loss per share for class A and 
  class B ordinary shares: 
 Class A ordinary shares - basic 
  and diluted                                    (5.24 )        (7.23)        (1.02) 
 Class B ordinary shares - basic 
  and diluted                                    (5.24 )        (7.23)        (1.02) 
 Weighted average shares outstanding 
  used in loss per share computation: 
 Class A ordinary shares - basic 
  and diluted                                86, 798,854    87,097,027    87,097,027 
 Class B ordinary shares - basic 
  and diluted                                 17,324,848    17,324,848    17,324,848 
 Other comprehensive income (loss), 
  net of tax of nil: 
 Foreign currency translation adjustments       (14,754)        47,296         6,649 
 Total comprehensive loss                      (560,307)     (707,712)      (99,490) 
 Total comprehensive loss attributable 
  to Burning Rock Biotech Limited's 
  shareholders                                 (560,307)     (707,712)      (99,490) 
 

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

 
                                                          As of 
                                                        September     September 
                                                           30,           30, 
                                           December 
                                           31, 2021        2022          2022 
                                         -----------  ------------  ----------- 
                                             RMB           RMB          US$ 
 ASSETS 
 Current assets: 
 Cash and cash equivalents                 1,431,317     1,009,790      141,954 
 Restricted cash                               7,795         4,216          593 
 Short-term investments                       63,757             -            - 
 Accounts receivable, net                     92,197       102,385       14,393 
 Contract assets, net                         42,391        46,591        6,550 
 Inventories, net                            123,210       150,428       21,147 
 Prepayments and other current assets, 
  net                                         60,279        41,220        5,794 
 Total current assets                      1,820,946     1,354,630      190,431 
                                         -----------  ------------  ----------- 
 Non-current assets: 
 Equity method investment                        910           644           91 
 Convertible note receivable                       -         5,000          703 
 Property and equipment, net                 325,438       288,499       40,556 
 Operating right-of-use assets                81,007        58,379        8,207 
 Intangible assets, net                        5,150         2,774          390 
 Other non-current assets                     45,136        21,369        3,004 
 Total non-current assets                    457,641       376,665       52,951 
                                         -----------  ------------  ----------- 
 TOTAL ASSETS                              2,278,587     1,731,295      243,382 
                                         ===========  ============  =========== 
 

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

 
                                                           As of 
                                                          September     September 
                                                             30,          30 , 
                                             December 
                                             31, 2021        2022          2022 
                                          ------------  ------------  ----------- 
                                               RMB           RMB          US$ 
 LIABILITIES AND SHAREHOLDERS' EQUITY 
 Current liabilities : 
 Accounts payable                               63,080        71,045        9,988 
 Deferred revenue                              142,871       168,260       23,654 
 Accrued liabilities and other current 
  liabilities                                  127,892        82,512       11,600 
 Customer deposits                                 972           403           57 
 Short-term borrowing                            2,370             -            - 
 Current portion of operating lease 
  liabilities                                   34,999        38,632        5,431 
 Other current liabilities                           -         2,557          359 
 Total current liabilities                     372,184       363,409       51,089 
                                          ------------  ------------  ----------- 
 Non-current liabilities: 
 Non-current portion of operating lease 
  liabilities                                   49,316        22,865        3,214 
 Other non-current liabilities                  11,776        46,079        6,478 
 Total non-current liabilities                  61,092        68,944        9,692 
                                          ------------  ------------  ----------- 
 TOTAL LIABILITIES                             433,276       432,353       60,781 
                                          ============  ============  =========== 
 
   Shareholders' equity: 
 Class A ordinary shares                           116           117           16 
 Class B ordinary shares                            21            21            3 
 Additional paid-in capital                  4,280,956     4,499,491      632,528 
 Treasury stock                                      -      (57,193)      (8,040) 
 Accumulated deficits                      (2,228,713)   (2,983,721)    (419,445) 
 Accumulated other comprehensive loss        (207,069)     (159,773)     (22,461) 
 Total shareholders' equity                  1,845,311     1,298,942      182,601 
                                          ------------  ------------  ----------- 
 TOTAL LIABILITIES AND SHAREHOLDERS' 
  EQUITY                                     2,278,587     1,731,295      243,382 
                                          ============  ============  =========== 
 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

 
                                               For the three months ended 
                                           September   September   September 
                                            30, 2021    30, 2022    30, 2022 
                                          ----------  ----------  ----------- 
                                              RMB         RMB         US$ 
 Net cash used in operating activities     (133,394)   (135,467)     (19,042) 
 Net cash used in investing activities      (72,085)    (20,148)      (2,832) 
 Net cash used in financing activities      (32,995)     (2,671)        (375) 
 Effect of exchange rate on cash, cash 
  equivalents and restricted cash              4,919      19,242        2,703 
 Net decrease in cash, cash equivalents 
  and restricted cash                      (233,555)   (139,044)     (19,546) 
 Cash, cash equivalents and restricted 
  cash at the beginning of period          1,883,265   1,153,050      162,093 
 Cash, cash equivalents and restricted 
  cash at the end of period                1,649,710   1,014,006      142,547 
 
 
 
 
                                                    For the nine months ended 
                                                September   September   September 
                                                 30, 2021    30, 2022    30, 2022 
                                               ----------  ----------  ---------- 
                                                   RMB         RMB         US$ 
 Net cash used in operating activities          (365,537)   (389,101)    (54,700) 
 Net cash generated from (used in) investing 
  activities                                      148,667     (2,430)       (339) 
 Net cash used in financing activities           (46,118)    (76,164)    (10,707) 
 Effect of exchange rate on cash, cash 
  equivalents and restricted cash                (12,508)      42,589       5,986 
 Net decrease in cash, cash equivalents 
  and restricted cash                           (275,496)   (425,106)    (59,760) 
 Cash, cash equivalents and restricted 
  cash at the beginning of period               1,925,206   1,439,112     202,307 
 Cash, cash equivalents and restricted 
  cash at the end of period                     1,649,710   1,014,006     142,547 
 

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

 
                                                 For the three months ended 
                         --------  -----------------------------------------------------  ----------- 
                                               September    December    March      June     September 
                           March      June        30,         31,        31,       30,         30, 
                            31 ,      30,        2021                    2022      2022       2022 
                            2021      2021                    2021 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
                                                           (RMB in thousands) 
 Gross profit: 
 Central laboratory 
  channel                  55,212    58,681       58,387      65,985    50,574    57,575       69,991 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 In-hospital channel       20,070    29,426       31,111      34,194    33,396    20,012       31,593 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Pharma research and 
  development channel       1,658     2,124        2,098       5,200     3,610     5,015        7,010 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Total gross profit        76,940    90,231       91,596     105,379    87,580    82,602      108,594 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Add: depreciation 
  and amortization: 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Central laboratory 
  channel                     117       284        1,254         995     2,553     2,545        3,138 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 In-hospital channel           79       113          109         130        93     1,428        2,479 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Pharma research and 
  development channel          10        40           19         856     2,493     4,327        2,805 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Total depreciation 
  and amortization 
  included in cost 
  of revenues                 206       437        1,382       1,981     5,139     8,300        8,422 
 Non-GAAP gross profit 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Central laboratory 
  channel                  55,329    58,965       59,641      66,980    53,127    60,120       73,129 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 In-hospital channel       20,149    29,539       31,220      34,324    33,489    21,440       34,072 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Pharma research and 
  development channel       1,668     2,164        2,117       6,056     6,103     9,342        9,815 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Total non-GAAP gross 
  profit                   77,146    90,668       92,978     107,360    92,719    90,902      117,016 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Non-GAAP gross margin 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Central laboratory 
  channel                   74.2%     73.7%        75.7%       77.9%     71.6%     76.5%        81.3% 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 In-hospital channel        69.5%     72.9%        71.4%       66.1%     68.4%     62.7%        68.6% 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Pharma research and 
  development channel       54.4%     31.9%        51.8%       64.0%     49.4%     51.7%        65.4% 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 Total non-GAAP gross 
  margin                    72.4%     71.2%        73.4%       72.9%     68.4%     69.5%        75.7% 
                         --------  --------  -----------  ----------  --------  --------  ----------- 
 

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November 16, 2022 02:00 ET (07:00 GMT)

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