KRTX Karuna Therapeutics Inc

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES                                                                                   
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940                       

1. Name and Address of Reporting Person * Ignelzi Troy A.	2. Issuer Name and Ticker or Trading Symbol Karuna Therapeutics, Inc. [ KRTX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) Chief Financial Officer
(Last)          (First)          (Middle) C/O KARUNA THERAPEUTICS, INC., 33 ARCH ST STE 3110	3. Date of Earliest Transaction (MM/DD/YYYY) 11/6/2020
(Street) BOSTON, MA 02110-1424 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	11/6/2020		M		564	A	$9.2	5564	D
Common Stock	11/6/2020		S		564	D	$108.15	5000	D
Common Stock	11/9/2020		M		8000	A	$9.2	13000	D
Common Stock	11/9/2020		S(1)		8000	D	$105.02	5000	D
Common Stock	11/9/2020		M		1318	A	$9.2	6318	D
Common Stock	11/9/2020		S		1318	D	$108.26 (2)	5000	D
Common Stock	11/10/2020		M		118	A	$9.2	5118	D
Common Stock	11/10/2020		S		118	D	$103.48	5000	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Option (right to buy)	$9.20	11/6/2020		M			564	3/1/2020	3/21/2029	Common Stock	564	$0	235230	D
Option (right to buy)	$9.20	11/9/2020		M			8000	3/1/2020	3/21/2029	Common Stock	8000	$0	227230	D
Option (right to buy)	$9.20	11/9/2020		M			1318	3/1/2020	3/21/2029	Common Stock	1318	$0	225912	D
Option (right to buy)	$9.20	11/10/2020		M			118	3/1/2020	3/21/2029	Common Stock	118	$0	225794	D

Explanation of Responses:
(1)	The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
(2)	The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $108.05 to $109.08, inclusive. The reporting person undertakes to provide to Karuna Therapeutics, Inc., any security holder of Karuna Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Ignelzi Troy A. C/O KARUNA THERAPEUTICS, INC. 33 ARCH ST STE 3110 BOSTON, MA 02110-1424			Chief Financial Officer

Signatures
/s/ Troy Ignelzi		11/10/2020
**Signature of Reporting Person		Date