UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )

Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐

Check the appropriate box:

F-star Therapeutics, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

LOGO online Go to www.envisionsreports.com/FSTX or scan the QR code - login details are located in the shared bar below. Notice of 2022 Annual Meeting of stockholders to be Held on June 16, 2022. Under securities and exchange commission rules, you are receiving this notice that the proxy materials for the annual meeting of stockholders are available on the internet. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important! This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The proxy statement, our form of proxy card, and our 2021 annual report to stockholders are available at: www.envisionreports.com/FSTX Easy Online Access — View your proxy materials and vote. Step 1: Go to www.envisionreports.com/FSTX. Step 2: Click on Cast Your Vote or Request Materials. Step 3: Follow the instructions on the screen to log in. Step 4: Make your selections as instructed on each screen for your delivery preferences. Step 5: Vote your shares. When you go online, you can also help the environment by consenting to receive electronic delivery of future materials. Obtaining a Copy of the Proxy Materials – If you want to receive a copy of the proxy materials, you must request one. There is no charge to you for requesting a copy. Please make your request as instructed on the reverse side on or before June 6, 2022 to facilitate timely delivery. 2NOT

Notice of 2022 Annual Meeting of Shareholders The 2022 Annual Meeting of Stockholders of F-Star Therapeutics, Inc., will be held on Thursday, June 16, 2022, 9:00am EST, virtually via the internet at meetnow.global/MFY57C6. To access the virtual meeting, you must have the information that is printed in the shaded bar located on the reverse side of this form. Proposals to be voted on at the meeting are listed below along with the Board of Directors’ recommendations. The Board of Directors recommend a vote FOR all the nominees listed and FOR Proposals 2 and 4 and 1 YEAR for Proposal 3: 1. To elect two (2) Class I directors of the Corporation to serve three-year terms expiring in 2025. 01—Pamela Klein, M.D. 02—Geoffrey Race 2. To consider a non-binding advisory vote on compensation of the Corporation's named executive officers. 3. To consider a non-binding advisory vote on the frequency of holding an advisory cover on compensation of the Corporation's named executive officers. 4. To ratify the appointment of RSM US LLP as the company's independent registered public accounting firm for fiscal year ending December 31, 2022. 5. To transact such other business that is properly presented at the annual meeting and any adjournments or postponements thereof. PLEASE NOTE – YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. Here’s how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials. PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials. — Internet – Go to www.envisionreports.com/FSTX. Click Cast Your Vote or Request Materials. — Phone – Call us free of charge at 1-866-641-4276. — Email – Send an email to investorvote@computershare.com with “Proxy Materials F-Star Therapeutics, Inc.” in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, all requests for a paper copy of proxy materials must be received by June 6, 2022.

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