Ad Hoc Announcement Pursuant to Art. 53 LR

Geneva, Switzerland, June 5, 2024 - Addex Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders, announced today that its 2024 Annual General Meeting will take place on Friday June 28, 2024, at 11:00 am CEST at the Campus Biotech, Chemin des Mines 9, 1202 Geneva (doors open at 10:30 am).

Agenda

1.   Approval of the Annual Report, the Annual Financial Statements and the Consolidated Financial Statements for the business year 20232.   Consultative vote on the Compensation Report for the business year 20233.   Appropriation of the results4.   Discharge of the members of the Board of Directors and of the Executive Management5.   Re-elections of the members of the Board of Directors and re-election of the Chairman of the Board of Directors5.1.      Re-election of Vincent Lawton as member and Chairman of the Board of Directors5.2.      Re-election of Raymond Hill as member of the Board of Directors5.3.      Re-election of Timothy Dyer as member of the Board of Directors5.4.      Re-election of Roger Mills as member of the Board of Directors5.5.      Re-election of Jake Nunn as member of the Board of Directors5.6.      Re-election of Isaac Manke as member of the Board of Directors

6.   Re-elections of the members of the Compensation Committee6.1.      Re-election of Vincent Lawton as member of the Compensation Committee6.2.      Re-election of Raymond Hill as member of the Compensation Committee

7.   Re-election of the Auditors8.   Re-election of the Independent Voting Rights Representative9.   Amendments to the Articles of Association9.1.      Increase of the capital band (article 3b of the Articles of Association)9.2.      Increase of the conditional share capital (article 3c of the Articles of Association)9.3.      Other amendments to the Articles of Association related to the revised corporate law9.3.1.      Matters related to shareholders and general meetings9.3.1.1.       Powers of the shareholders meeting (article 8 of the Articles of Association)9.3.1.2.       Ordinary and Extraordinary Meeting of shareholders (article 9 of Articles of Association)9.3.1.3.       Agenda (article 11 of Articles of Association) 9.3.2.       Attributions of the Board of Directors (article 19 of Articles of Association)9.3.3.       Compensation and Mandates Outside of the Group9.3.3.4.       Additional amounts in case of changes in the Executive Management (article 28 of Articles of Association)9.3.3.5.       Agreements with members of the Board of Directors and of the Executive Management (article 29 of the Articles of Association)9.3.3.6.       Mandates Outside the Group (article 31 of the Articles of Association) 10.   Approval of the compensation of the members of the Board of Directors and of the Executive Management10.1.      Compensation of the members of the Board of Directors10.2.      Compensation of the members of the Executive Management

11.   MiscellaneousThe full invitation to the AGM 2024 may be found in the General Meetings section of the Company’s website here.

About Addex:Addex Therapeutics is a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders. Addex’s lead drug candidate, ADX71149 (mGlu2 positive allosteric modulator or PAM), developed in collaboration with Janssen Pharmaceuticals Inc., has recently completed a Phase 2 clinical study for the treatment of epilepsy. The Company’s second clinical program, dipraglurant (mGlu5 negative allosteric modulator or NAM), is under evaluation for future development in dyskinesia associated with Parkinson’s disease and post-stroke/TBI recovery. Addex partnership with Indivior on GABAB PAM is advancing multiple drug candidates through clinical candidate selection for substance use disorder. Under the agreement with Indivior, Addex is advancing an independent GABAB PAM program for chronic cough through clinical candidate selection. Addex also holds a 20% share in a private company, Neurosterix LLC which is advancing a portfolio of allosteric modulator programs including M4PAM for schizophrenia, mGlu7NAM for stress related disorders and mGlu2NAM for mild neurocognitive disorders. Addex shares are listed on the SIX Swiss Exchange and American Depositary Shares representing its shares are listed on the NASDAQ Capital Market, and trade under the ticker symbol “ADXN” on each exchange. For more information, visit www.addextherapeutics.com

Contacts:

Tim DyerChief Executive OfficerTelephone: +41 22 884 15 55PR@addextherapeutics.com Mike SinclairPartner, Halsin Partners+44 (0)7968 022075msinclair@halsin.com

Addex Forward Looking Statements:This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements about the intended use of proceeds of the offering. The words “may,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “target” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release, are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, uncertainties related to market conditions. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Addex Therapeutics’ Annual Report on Form 20-F for the year ended December 31, 2023, as filed with the SEC on April 18, 2024, the final prospectus supplement and accompanying prospectus and other filings that Addex Therapeutics may make with the SEC in the future. Any forward-looking statements contained in this press release represent Addex Therapeutics’ views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date. Addex Therapeutics explicitly disclaims any obligation to update any forward-looking statements.

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