Arno Therapeutics, Inc. (OTCQB:ARNI), a clinical stage
biopharmaceutical company focused on the development of oncology
therapeutics, today announced data from a preclinical study
supporting further evaluation of its lead compound onapristone as a
potential treatment for castration-resistant prostate cancer
(CRPC). Results were presented during a poster session on Thursday,
October 24 and in an oral presentation on Saturday, October 26 at
the 20th Annual 2013 Prostate Cancer Foundation (PCF) Scientific
Retreat, held October 24-26, 2013 in National Harbor, Md.
This year there will be more than 238,000 estimated new cases
and 29,000 deaths from prostate cancer in the United
States.i Due to initial steroid hormone-dependence, androgen
deprivation is the main treatment for advanced disease. However,
despite advances in targeting the androgen receptor (AR) pathway
leading to significant survival benefit for patients with CRPC,
resistance inevitably emerges. Research has shown that the
progesterone receptor (PR) becomes overexpressed during prostate
cancer progression on hormonal treatments.ii
Onapristone is an oral, anti-progestin hormone blocker that has
been shown to have considerable anti-tumor activity in breast
cancer. Onapristone appears to have a unique ability to block the
activated progesterone receptor (APR), which is believed to be a
mechanism that may inhibit the growth of breast, endometrial and
other tumors. The APR has the potential to function as a biomarker
of anti-progestin activity.
"Overall, these data suggest that the progesterone receptor is
present and is potentially active in a subset of castrate-resistant
prostate cancers tumors, further supporting the activated form of
progesterone receptor as a target for treatment with an
anti-progestin like onapristone," said Alex Zukiwski, Chief Medical
Officer of Arno Therapeutics and the lead author of the poster.
"Prostate cancer is the most frequently diagnosed cancer in
men and we plan to evaluate onapristone as a potential personalized
therapy for patients in this population who will most likely
benefit."
Title: Investigation of the activated form of
the progesterone receptor (APR) in castrate-resistant prostate
cancer
Authors: Alex Zukiwski, Jacques Bosq, Erard M. Gilles,
Arie Belldegrun
As an exploratory analysis of activated androgen receptor (AR),
the preclinical study evaluated five CRPC specimens processed with
standard immunohistochemistry (IHC) techniques to determine the PR
sub-nuclear distribution. APR positive was defined as any tumor
with more than 5 percent APR cells (shown as aggregate or foci
pattern). The study aimed to detect activated PR in archived
castrate-resistant prostate cancers and determine the proportion of
cases with activated PR, which would have the potential to respond
to anti-progestins.
The analysis illustrated that the activated form of the AR
subnuclear distribution pattern was observed. In the initial series
of CRPC specimens examined, four were AR positive and two had the
aggregated pattern consistent with the activated form of the AR.
PR was expressed in three of the five CRPC tumors tested to
date and activated PR was detected in two of the five CRPC
tumors.
These data suggest that PR is present and is potentially active
in a subset of castrate-resistant prostate cancers tumors. In such
cases, investigation of an anti-progestin treatment, such as
onapristone, is warranted as it could inhibit tumor PR activity to
disrupt any PR-driven proliferation. The findings suggest
that activated PR detection in prostate cancer is potentially
valuable to identify patients who may benefit from anti-progestin
treatment.
To investigate onapristone in this patient population, Arno is
planning a Phase I study in male patients with androgen-independent
prostate cancer which has progressed on either abiraterone or
enzalutamide, to determine the safety profile and the recommended
dose for further study and evaluate preliminary efficacy in
PR-positive and activated PR-positive CRPC.
Glenn Mattes, President and Chief Executive Officer of Arno
Therapeutics, said, "We are encouraged by these findings as they
further support the evaluation of onapristone as a potentially
effective hormone treatment in both men's and women's cancers. Data
we have presented to date collectively point to the significance of
the role of anti-progestins and using APR as a biomarker in solid
tumors. To build upon these results, we are planning a Phase I
trial to investigate onapristone in men with castrate resistant
prostate cancer."
About Arno Therapeutics
Arno Therapeutics is a clinical stage biopharmaceutical company
developing innovative products for the treatment of cancer.
Arno has exclusive worldwide rights to develop and market three
innovative anti-cancer product candidates. These compounds
are in clinical or preclinical development as product candidates to
treat hematologic malignancies and solid tumors. For more
information about the company, please
visit www.arnothera.com.
Forward-Looking Statements
This press release contains forward-looking statements that
involve substantial risks and uncertainties. These statements are
often, but not always, made through the use of words or phrases
such as "anticipates," "expects," "plans," "believes," "intends,"
and similar words or phrases. These forward-looking statements
include, without limitation, statements regarding Arno's belief
about the ability of onapristone to treat prostate and other
cancers, statements regarding Arno's plans to initiate clinical
trials of onapristone in men with prostate cancer, statements
regarding the timing, progress and anticipated results of the
clinical development of onapristone, as well as statements
regarding Arno's strategy, future operations, outlook, milestones,
future financial position, future financial results, plans and
objectives. We may not actually achieve these plans, intentions or
expectations and Arno cautions investors not to place undue
reliance on our forward-looking statements. Actual results or
events could differ materially from the plans, intentions and
expectations disclosed in the forward-looking statements we make.
Various important factors could cause actual results or events to
differ materially from the forward-looking statements that we make.
Such factors include, among others, risks that the results of
clinical trials will not support our claims or beliefs concerning
the effectiveness of onapristone or any of our other product
candidates, our ability to finance the development of our product
candidates, regulatory risks, and our reliance on third party
researchers and other collaborators. Additional risks are described
in the company's Annual Report on Form 10-K for the year
ended December 31, 2012. Arno is providing this information as
of the date of this press release and does not undertake any
obligation to update any forward-looking statements as a result of
new information, future events or otherwise.
i American Cancer Society. Cancer Facts &
Figures 2013. Available at:
http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf
ii Bonkhoff 2001, Lange 2007.
CONTACT: The Ruth Group
Stephanie Carrington (investors)
scarrington@theruthgroup.com
(646) 536-7017
Kirsten Thomas (media)
kthomas@theruthgroup.com
(646) 536-7014
Arno Therapeutics
Glenn Mattes
gm@arnothera.com
(862) 703-7176
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