FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Squeri Stephen J 2. Issuer Name and Ticker or Trading Symbol AMERICAN EXPRESS CO [ AXP ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chairman and CEO
(Last)         (First)         (Middle)
200 VESEY STREET, AMERICAN EXPRESS TOWER
3. Date of Earliest Transaction (MM/DD/YYYY)
1/26/2021
(Street)
NEW YORK, NY 10285-5001
(City)       (State)       (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  1/26/2021    A(1)    61236  A $121.15  61236  D   
Common Stock  1/26/2021    F(2)    29951  D $121.15  31285  D   
Common Stock                 205877 (3) I  by GRAT 
Common Stock                 123.37 (4) I  401(k) Trust 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (Right to Buy)  $97.98  1/26/2021    A (5)    66225      1/26/2021  1/26/2028  Common Stock  66225  $0  66225  D   

Explanation of Responses:
(1)  Represents shares acquired pursuant to vesting of Restricted Stock Units that were granted to the reporting person in January 2018 and have vested based on the Company's 2018-20 average return on equity performance.
(2)  The reported disposition represents the surrender of shares to satisfy tax obligations arising from the vesting of Restricted Stock Units.
(3)  Includes shares acquired pursuant to dividend reinvestment.
(4)  Shares held in reporting person's account under the Company's Retirement Savings Plan. This plan uses unit accounting, and the number of shares that a participant is deemed to hold varies with the unit price of the Company pooled stock fund.
(5)  The reported acquisition represents the vesting of Stock Options that were granted to the reporting person in January 2018. These options became exercisable on January 26, 2021.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Squeri Stephen J
200 VESEY STREET, AMERICAN EXPRESS TOWER
NEW YORK, NY 10285-5001
X
Chairman and CEO

Signatures
/s/ Kristina V. Fink, attorney-in-fact 1/28/2021
**Signature of Reporting Person Date