Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Foster Alan Charles

2. Date of Event Requiring Statement (MM/DD/YYYY) 4/16/2021

3. Issuer Name and Ticker or Trading Symbol

OTONOMY, INC. [OTIC]

(Last) (First) (Middle)

C/O OTONOMY, INC., 4796 EXECUTIVE DRIVE

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director _____ 10% Owner
___X___ Officer (give title below) _____ Other (specify below)
Chief Scientific Officer /

(Street)

SAN DIEGO, CA 92121

(City) (State) (Zip)

5. If Amendment, Date Original Filed(MM/DD/YYYY)

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	51403 ⁽¹⁾	D

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Option (right to buy)	⁽²⁾	1/19/2028	Common Stock	35000	$5.675	D
Stock Option (right to buy)	⁽²⁾	1/19/2028	Common Stock	15000	$5.675	D
Stock Option (right to buy)	⁽²⁾	1/19/2028	Common Stock	17000	$5.675	D
Stock Option (right to buy)	⁽²⁾	1/19/2028	Common Stock	20000	$5.675	D
Stock Option (right to buy)	2/1/2019 ⁽³⁾	2/1/2028	Common Stock	70000	$5.80	D
Stock Option (right to buy)	1/15/2020 ⁽³⁾	1/15/2029	Common Stock	80000	$2.02	D
Stock Option (right to buy)	1/15/2021 ⁽³⁾	1/15/2030	Common Stock	80000	$3.54	D
Stock Option (right to buy)	1/15/2022 ⁽³⁾	1/15/2031	Common Stock	60000	$5.20	D

Explanation of Responses:
(1)	Includes 50,000 Restricted Stock Units ("RSUs"). Twenty-five percent (25%) of the RSUs will vest on the one (1) year anniversary of March 23, 2021 (the "Vesting Commencement Date") and seventy-five percent (75%) of the RSUs will vest on the two-year anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service as of each such vesting date.
(2)	The shares subject to the option are fully vested and exercisable.
(3)	One-fourth (1/4) of the shares subject to the option vest on the one (1) year anniversary of the Vesting Commencement Date, and one forty-eighth (1/48) of the shares vest monthly thereafter, subject to the Reporting Person's continued service as of each such vesting date.

Remarks:
Exhibit 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Foster Alan Charles C/O OTONOMY, INC. 4796 EXECUTIVE DRIVE SAN DIEGO, CA 92121			Chief Scientific Officer