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This Schedule 13G/A is being jointly filed by Partner Fund Management, L.P. (“PFM”), Partner
Fund Management GP, LLC (“PFM-GP”), Partner Investment Management, L.P. (“PIM”), Partner Investment Management
GP, LLC (“PIM-GP”), Brian D. Grossman (“Grossman”) and Christopher M. James (“James” and, collectively
with PFM, PFM-GP, PIM, PIM-GP and Grossman, the “Reporting Persons”) with respect to shares of common stock of the
above-named issuer owned by Healthcare Emerging Growth Master Fund, L.P., a Cayman Islands limited partnership (“HEGM”),
PFM Global Long Alpha Master Fund, L.P., a Cayman Islands limited partnership (“GLAM”), PFM Global Long Alpha Institutional
Master Fund, L.P., a Cayman Islands limited partnership (“GLAI”), PFM Healthcare Master Fund, L.P., a Cayman Islands
limited partnership (“HCM”), PFM Healthcare Long Master Fund, L.P., a Cayman Islands limited partnership (“HCLM”),
PFM Thematic Growth Master Fund, L.P., a Cayman Islands limited partnership (“TGM”), PFM Thematic Growth Institutional
Master Fund, L.P., a Cayman Islands limited partnership (“TGI”), PFM Therapeutics Master Fund, L.P., a Cayman Islands
limited partnership (“TM”), PFM Healthcare Principals Fund, L.P., a Delaware limited partnership (“HCP”),
and PFM Thematic Growth Principals Fund, L.P., a Delaware limited partnership (“TGP” and, collectively with HEGM, GLAM,
GLAI, HCM, HCLM, TGM, TGI, TM and HCP, the “Funds”).
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