MARLBOROUGH, Mass.,
April 25, 2017 /PRNewswire/ -- RXi
Pharmaceuticals Corporation (NASDAQ: RXII), a clinical-stage RNAi
company developing innovative therapeutics that address significant
unmet medical needs, today announced that the Company's Vice
President of Research, Dr. Karen
Bulock, will present at the 19th Annual TIDES:
Oligonucleotide and Peptides Therapeutics Conference. The
TIDES forum provides access to an extensive network of industry
leaders to build successful partnerships and accelerate products
from early discovery through late-stage development and
commercialization. This year's conference will be held April 30 – May 3,
2017 at the Manchester Grand Hyatt, San Diego, California.
- Date and Time: Tuesday, May 2,
2017 9:30 am PDT
Title: Reduced in vivo Tumor Growth Using CAR T-cells
Treated ex vivo with PD-1 Targeting sd-rxRNA®
Track: Oligonucleotide Discovery, Preclinical and
Clinical
Abstract: Silencing of immunosuppressive genes, such as
PD-1, by ex vivo treatment with a self-delivering RNAi
(sd-rxRNA) may improve the efficacy of CAR-T cells for the
treatment of solid tumors. Meso-CAR-T cells (expressing antibody
fragments that target mesothelin) were treated ex vivo with
an anti-PD-1 sd-rxRNA. Direct tumor injection of these modified
CAR-T cells in a mouse model of human ovarian cancer resulted in a
statistically significant reduction of tumor growth.
The presentation will be available under the "Investors –
Presentations & Posters" section of the Company's
website, www.rxipharma.com approximately 1 hour following
the presentation.
About RXi's Proprietary Self-delivering RNAi (sd-rxRNA)
Technology Platform
RXi's proprietary sd-rxRNA technology has many advantages over
its competitors in the RNAi space. Scientists at RXi have
designed chemically-modified RNAi compounds with improved drug-like
properties that are potent, stable and specific. These
proprietary compounds have built-in delivery properties and
therefore do not require a delivery vehicle for local therapeutic
applications. The enhanced properties of sd-rxRNA
include: efficient spontaneous cellular uptake, stability,
reduced potential for immune stimulation, and potent, long-lasting
intracellular activity. All cell types tested (primary,
neuronal and non-adherent) internalize sd-rxRNA compounds uniformly
and efficiently, resulting in potent and long lasting
silencing. sd‑rxRNA compounds have the ability to selectively
block the expression of any target in the genome, thus providing
applicability to a broad spectrum of therapeutic areas.
About RXi Pharmaceuticals
RXi Pharmaceuticals Corporation (NASDAQ: RXII) is a
clinical-stage company developing innovative therapeutics that
address significant unmet medical needs. Building on the
pioneering discovery of RNAi, scientists at RXi have harnessed the
naturally occurring RNAi process which has the ability to "silence"
or down-regulate the expression of a specific gene that may be
overexpressed in a disease condition. RXi developed a robust
RNAi therapeutic platform including self-delivering RNA (sd-rxRNA)
compounds that have the ability to highly selectively block the
expression of any target in the genome, thus providing
applicability to many therapeutic areas. Our current programs
include dermatology, ophthalmology and cell-based
immunotherapy. RXi's extensive patent portfolio provides for
multiple product and business development opportunities across a
broad spectrum of therapeutic areas and we actively pursue research
collaborations, partnering and out-licensing opportunities with
academia and pharmaceutical companies. Additional information
may be found on the Company's website, www.rxipharma.com.
Forward-Looking Statements
This press release contains forward-looking statements within
the meaning of the Private Securities Litigation Reform Act of
1995. Such statements include, but are not limited to, statements
about: our ability to successfully develop RXI-109, Samcyprone™ and
our other product candidates (collectively "our product
candidates"); the future success of our clinical trials with our
product candidates; the timing for the commencement and completion
of clinical trials; our ability to enter into strategic
partnerships and the future success of these strategic
partnerships; and our ability to deploy our sd-rxRNA® technology
through partnerships, as well as the prospects of these
partnerships to provide positive returns. Forward-looking
statements about expectations and development plans of RXi's
product candidates and partnerships involve significant risks and
uncertainties, including the following: risks that we may not be
able to successfully develop and commercialize our product
candidates; risks that product development and clinical studies may
be delayed, not proceed as planned and/or be subject to significant
cost over-runs; risks related to the development and
commercialization of products by competitors; risks related to our
ability to control the timing and terms of collaborations with
third parties; and risks that other companies or organizations may
assert patent rights preventing us from developing or
commercializing our product candidates. Additional risks are
detailed in our most recent Annual Report on Form 10-K and
subsequent Quarterly Reports on Form 10-Q under the caption "Risk
Factors." Readers are urged to review these risk factors and
to not act in reliance on any forward-looking statements, as actual
results may differ from those contemplated by our forward-looking
statements. RXi does not undertake to update forward-looking
statements to reflect a change in its views, events or
circumstances that occur after the date of this release.
Contact
RXi Pharmaceuticals Corporation
Tamara McGrillen
508-929-3646
tmcgrillen@rxipharma.com
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