UPDATE -- Pacific Biosciences Improves Key Applications on the Sequel System with New Chemistry and Software Release
January 09 2017 - 12:27PM
Pacific Biosciences of California, Inc. (Nasdaq:PACB) today
announced a new version of chemistry (V2) and software (V4) for the
Sequel™ System. The new release improves the system’s ability to
support important applications such as structural variant detection
and targeted sequencing—including metagenomics, minor variant
detection and isoform sequencing—by achieving mean read lengths of
10-18 kb, with half of the data in reads >20 kb, and throughput
of 5-8 Gb, depending on the sample type and preparation method
used. In addition to these applications, the high consensus
accuracy, uniform coverage, and long reads inherent to the Sequel
System continue to make it ideal for applications such as de
novo genome assembly. Along with the performance improvements,
the system is now capable of loading 80 kb sequencing libraries.
The Sequel System is PacBio’s latest platform based on its
Single Molecule, Real-Time (SMRT®) Sequencing technology. Since the
launch of the system in fall of 2015, PacBio has installed more
than 110 Sequel Systems globally. The latest release includes a new
version of the consumable SMRT Cells that is optimized for the new
sequencing chemistry kits. The company has also made updates to its
base calling algorithm that increase accuracy, and added new
features in the Sequel System software package to help support
clinical research applications. The V2 chemistry and V4 software
updates will be available on January 23, 2017.
This release improves users’ ability to perform low-fold
structural variant detection and key targeted sequencing
applications. For structural variant detection, customers can now
accomplish the same or better quality of results for structural
variant analysis using, on average, half the number of SMRT Cells
compared to the previously available chemistry. The increase in
read length provided by the new chemistry also enables the
detection of larger-scale structural variants; in particular, there
is a 3-fold increase in sensitivity of insertions over 5 kb. For
targeted sequencing, the new chemistry and software gives users
more flexibility. For example, for minor variant detection,
customers can either gain detection sensitivity or reduce cost per
sample with increased sample multiplexing.
“This release is part of our continued commitment to increasing
the performance of the Sequel System, and we are very pleased with
the data we are seeing both internally and at our beta-test sites,”
said Kevin Corcoran, Senior Vice President of Market Development
for Pacific Biosciences. “We are focused on improving the key
applications for our customers where SMRT Sequencing provides
unique advantages. And, by increasing throughput, we are making
projects more cost effective.”
More information about Sequel is available at:
http://www.pacb.com/sequel/.
About Pacific Biosciences
Pacific Biosciences of California, Inc. (NASDAQ:PACB)
offers sequencing systems to help scientists resolve genetically
complex problems. Based on its novel Single Molecule, Real-Time
(SMRT®) technology, Pacific Biosciences’ products enable: de novo
genome assembly to finish genomes in order to more fully identify,
annotate and decipher genomic structures; full-length transcript
analysis to improve annotations in reference genomes, characterize
alternatively spliced isoforms in important gene families, and find
novel genes; targeted sequencing to more comprehensively
characterize genetic variations; and real-time kinetic information
for epigenome characterization. Pacific Biosciences’ technology
provides high accuracy, ultra-long reads, uniform coverage, and is
the only DNA sequencing technology that provides the ability to
simultaneously detect epigenetic changes. PacBio® sequencing
systems, including consumables and software, provide a simple,
fast, end-to-end workflow for SMRT Sequencing. More information is
available at www.pacb.com.
Forward-Looking Statements
All statements in this press release that are not historical are
forward-looking statements, including, among other things,
statements relating to product improvements, updates or new
features, future availability, uses, quality or performance of, or
benefits of using, products or technologies, and other future
events. You should not place undue reliance on forward-looking
statements because they involve known and unknown risks,
uncertainties, changes in circumstances and other factors that are,
in some cases, beyond Pacific Biosciences’ control and could cause
actual results to differ materially from the information expressed
or implied by forward-looking statements made in this press
release. Factors that could materially affect actual results can be
found in Pacific Biosciences’ most recent filings with
the Securities and Exchange Commission, including Pacific
Biosciences’ most recent reports on Forms 8-K, 10-K and 10-Q, and
include those listed under the caption “Risk Factors.”
Pacific Biosciences undertakes no obligation to revise or update
information in this press release to reflect events or
circumstances in the future, even if new information becomes
available.
Contacts
Media:
Nicole Litchfield
415.793.6468
nicole@bioscribe.com
Investors:
Trevin Rard
650.521.8450
ir@pacificbiosciences.com
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