Whalatane
6 days ago
Z. To correct the previous post where I mentioned VERA .
Their LN P 3 trial has been suspended
This suspension follows a previous setback with atacicept in lupus nephritis - the Phase II/III APRIL-LN trial evaluating atacicept in addition to mycophenolate mofetil was prematurely terminated due to unexpected declines in serum IgG levels and occurrence of serious infections in patients receiving atacicept.
It's worth noting that atacicept has shown more promising results in other conditions like IgA nephropathy, where it demonstrated an acceptable safety profile and improvements in proteinuria in the Phase II JANUS study. However, its development for lupus nephritis has faced challenges, with the COMPASS trial being the latest setback. The lack of safety concerns as the reason for suspension suggests there may be other factors at play, but without more information, the exact cause remains unclear.
So VERA's LN program is no longer a threat to AUPH.
Kiwi
Whalatane
6 days ago
Z. Is Lupkynis still a Tier 5 drug on formularies .
If so
For tier 5 drugs, which are typically specialty drugs, the copay structure is different from lower tiers. Instead of a fixed copay amount, you generally pay a percentage of the drug's cost, known as coinsurance.
According to the search results:
For most plans, you'll pay 25% to 33% of the retail cost for drugs in tier 5.
Tier 5 is often referred to as the "Specialty Tier" and includes unique and/or very high-cost drugs.
The coinsurance model means you pay a percentage of the total drug cost rather than a fixed copay amount.
Even if the patient makes it past the PA hurdles , they then need to deal with the copay
RMB posted the retail cost in a previous post ....how many " people of color "...or anyone else for that matter can pay 25-33% of the retail cost annually.
Other Co's like VERA also have LN drugs in clinical trials with promising data so far
https://veratx.com/science/atacicept-in-ln/
Good luck ... No position
Kiwi
zzaatt
6 days ago
Prior authorizations hurdles ...suggest you learn about them
Your source of information (your wife) gives you a very narrow perspective. I suggest you expand on your information gathering efforts.
I have personally seen VERY expensive drugs (Entyvio, $20K/month) go from very difficult to get (let all cheap drugs fail, patient suffer, long term damage, then more expensive treatment long term), and now, much easier to get as initial treatment.
I expect the same for Lupkynis, and I think we're getting very close to that point. As I said before, the fact that "communities of color" are disproportionally effected should also play some role!
See this from link:
Lupus nephritis is a serious chronic disease, one that has a disproportionately large impact on Black, Hispanic, and other communities of color in the US. Both belimumab and voclosporin are important new treatment options. Despite remaining uncertainty about both treatmentsโ longer-term outcomes, their estimated net prices appear to be aligned with their anticipated clinical benefits. More research is needed to confirm these benefits, but
for patients and clinicians to have responsibly priced options specifically indicated for lupus nephritis is a win for patients and the entire health system.
rosemountbomber
2 weeks ago
SEOUL, South Korea--(BUSINESS WIRE)--ILJIN SNT Co., Ltd. ("ILJIN"), one of the largest shareholders of Aurinia Pharmaceuticals (NASDAQ: AUPH) ("Aurinia" or the "Company"), today issued an open letter to fellow shareholders. The full text of the letter is below.
=======================
July 11, 2024
Fellow Aurinia Shareholders,
Last month, Aurinia (โCompanyโ) announced the voting results of its 2024 annual general meeting of shareholders (โAGMโ). The Company announced that four directors -- (i) Peter Greenleaf, President and CEO and a Director, (ii) Daniel G. Billen, Director and Chair of the Board, (iii) R. Hector MacKay-Dunn, J.D, Director, and (iv) Brinda Balakrishnan, Director -- received less than the majority support required under the Companyโs Majority Voting Policy.
No doubt the AGM results are a step in the right direction for the future of Aurinia. In this connection, we call on the Companyโs Board to honor the voices of shareholders as expressed through the AGM, and accept the resignations of the four directors in accordance with the AGM voting results. We fully expect the Board will change as a result of this vote and begin to serve as a strong, effective board in ensuring improved management performance and securing a breakthrough in the Company stockโs performance in the near future.
So, after months of efforts, including issuance of the three public letters, ILJIN simply wanted to express our sincere gratitude to our fellow shareholders for having the courage to step up and finally making our voices heard. Our collective actions prove that no longer can entrenched management get away with massive losses on shareholders without a consequence to their compensation from the Company, and no longer may the Companyโs management enrich themselves through the unrestrained grant of free RSUs -- irrespective of the Companyโs performance.
Now, the AGM has paved the path for a change to the Companyโs Board, we will need new directors who could help the Company forge a new strategic direction and successfully implement the strategic change. In this respect, we intend to maintain our vigilance and continue to press for the Board to listen to the constituent shareholders both in the selection of the composition of the Companyโs new Board and adoption of a new growth strategy for Aurinia. We implore the Company to take the necessary changes at the Company to restore shareholder value in the nearest future possible.
Together, we will make a difference to the future of Aurinia.
Contacts
Media:
Yoonhwa Lee
yoonhwa.lee@iljin.co.kr
ILJIN SNT CO., LTD.
Pablo Bio
2 months ago
The best news, if true, ((Advancing autoimmune pipeline with Phase 1 clinical program for AUR200,))
Dear Fellow Shareholders:
Auriniaโs Board of Directors and management team have been taking a range of actions to position the Company for sustainable success and build value for shareholders, while staying true to our core focus of delivering therapies to treat targeted patient populations with high unmet medical needs. We believe we have established strong momentum in the business based on recent actions to support our strategy in three key areas:
Focus on commercial execution after restructuring operations
Maximizing free cash flows, moving towards profitability, currently debt free with excess of $320M in cash, cash equivalents, restricted cash and investments
Advancing autoimmune pipeline with Phase 1 clinical program for AUR200, a potential next generation therapy for B-cell mediated autoimmune diseases that targets both BAFF (B-cell Activating Factor) and APRIL (A Proliferation-Inducing Ligand)