FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Hernandez Rulfo Fernando 2. Date of Event Requiring Statement (MM/DD/YYYY)
7/22/2020 

3. Issuer Name and Ticker or Trading Symbol OPKO HEALTH, INC. [OPK]
(Last)       (First)       (Middle)
4400 BISCAYNE BLVD.
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
CAO, Treasurer /
(Street)
MIAMI, FL 33137      
(City)             (State)             (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock  87  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   (1) 6/11/2024  Common Stock  40000  $9.10  D   
Stock Option (Right to Buy)   (2) 3/17/2025  Common Stock  60000  $14.42  D   
Stock Option (Right to Buy)   (3) 3/31/2026  Common Stock  75000  $10.41  D   
Stock Option (Right to Buy)   (4) 6/20/2028  Common Stock  50000  $4.46  D   
Stock Option (Right to Buy)   (5) 6/30/2029  Common Stock  100000  $2.47  D   
Stock Option (Right to Buy)   (6) 6/3/2030  Common Stock  100000  $2.27  D   

Explanation of Responses:
(1)  This option will vest in four equal annual installments beginning June 12, 2015.
(2)  This option will vest in four equal annual installments beginning March 18, 2016.
(3)  This option will vest in four equal annual installments beginning April 1, 2017.
(4)  This option will vest in four equal annual installments beginning June 21, 2019.
(5)  This option will vest in four equal annual installments beginning July 1, 2020.
(6)  This option will vest in four equal annual installments beginning June 4, 2021.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Hernandez Rulfo Fernando
4400 BISCAYNE BLVD.
MIAMI, FL 33137


CAO, Treasurer

Signatures
Rulfo F. Hernandez 7/24/2020
**Signature of Reporting Person Date
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