ARIAD Pharmaceuticals, Inc. (NASDAQ: ARIA) today announced the
schedule of several data presentations on Iclusig® (ponatinib) that
will take place at the 55th Annual Meeting of the American Society
of Hematology (ASH) being held in New Orleans, December 7 to 10,
2013. The schedule and meeting location for the sessions at ASH,
together with the abstract information are listed below:
PACE Trial: Two-Year Follow Up in
Chronic Phase Patients
Title: Ponatinib in Patients with Chronic Myeloid Leukemia
(CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic
Leukemia (Ph+ ALL) Resistant or Intolerant to Dasatinib or
Nilotinib, or with the T315I BCR-ABL Mutation: 2-Year Follow-Up of
the PACE Trial Oral Session: Chronic Myeloid Leukemia – Therapy:
Emerging Aspects of Monitoring and Long Term Treatments Date &
Time: Monday, December 9, 2013, 4:45 p.m. Abstract No.: 650
Presenter: Jorge E. Cortes, M.D. (The University of Texas MD
Anderson Cancer Center) Location: Hall E, Room E3
PACE Trial: Management of Adverse
Events
Title: Ponatinib in Heavily Pretreated Patients with Chronic
Phase Chronic Myeloid Leukemia (CP-CML): Management of Adverse
Events (AEs) Poster Session: Chronic Myeloid Leukemia - Therapy:
Poster I Date & Time: Saturday, December 7, 2013, 5:30 – 7:30
p.m. Abstract No.: 1496 Author: Philipp D. Le Coutre, M.D.
(Charité-Universitätsmedizin Berlin) Location: Hall E
PACE Trial: Post-Dasatinib
Efficacy and Safety
Title: Efficacy and Safety of Ponatinib Following Failure of
Dasatinib in Patients (pts) with Chronic Phase Chronic Myeloid
Leukemia (CP-CML) in the PACE Trial Poster Session: Chronic Myeloid
Leukemia - Therapy: Poster I Date & Time: Saturday, December 7,
2013, 5:30 – 7:30 p.m. Abstract No.: 1498 Author: Andreas Hochhaus,
M.D. (University Medical Center Jena in Germany) Location: Hall E
PACE Trial: Post-Nilotinib Efficacy and
Safety
Title: Efficacy and Safety of Ponatinib Following Failure of
Nilotinib in Patients with Chronic Phase Chronic Myeloid Leukemia
(CP-CML) in the PACE Trial Poster Session: Chronic Myeloid Leukemia
- Therapy: Poster II Date & Time: Sunday, December 8, 2013,
6:30 – 8:30 p.m. Abstract No.: 2738 Author:
Hagop M. Kantarjian, M.D. (The University
of Texas MD Anderson Cancer Center)
Location: Hall E
PACE Trial: Baseline BCR-ABL Mutations
Identified by Mass Spectrometry
Title: Additional BCR-ABL1 Mutations Identified by Sensitive
Mass Spectrometry in Chronic Phase CML Patients with T315I Treated
with Ponatinib Are Associated with Relatively Inferior Responses
and Outcomes Oral Session: Chronic Myeloid Leukemia - Therapy:
Emerging Aspects of Monitoring and Long Term Treatments Date &
Time: Monday, December 9, 2013 at 5:00 p.m. Abstract No.: 651
Presenter: Wendy T. Parker, Ph.D. (Department of Genetics and
Molecular Pathology, Centre for Cancer Biology, Adelaide,
Australia) Location: Hall E, Room E3
PACE Trial: Baseline BCR-ABL Mutations
Identified by Next-Generation Sequencing
Title: Impact of Baseline (BL) Mutations, Including
Low-Level and Compound Mutations, on Ponatinib Response and End of
Treatment (EOT) Mutation Analysis in Patients (Pts) with Chronic
Phase Chronic Myeloid Leukemia (CP-CML) Oral Session: Chronic
Myeloid Leukemia - Therapy: Emerging Aspects of Monitoring and Long
Term Treatments Date & Time: Monday, December 9, 2013, 5:15
p.m. Abstract No.: 652
Presenter:
Michael Deininger, M.D., Ph.D. (University
of Utah School of Medicine Huntsman Cancer Institute)
Location: Hall E, Room E3
PACE Trial: Dose Modification
Title: Clinical Impact of Dose Modification on Response to
Ponatinib in Patients with Chronic Phase Chronic Myeloid Leukemia
(CP-CML) Poster Session: Chronic Myeloid Leukemia - Therapy: Poster
III Date & Time: Monday, December 9, 2013, 6:00 – 8:00 p.m.
Abstract No.: 4007 Presenter: Javier Pinilla-Ibarz, M.D., Ph.D. (H.
Lee Moffitt Cancer Center) Location: Hall E
Investigator Sponsored Trial: MD
Anderson’s Front Line Study
Title: Ponatinib as Initial Therapy for Patients with
Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Poster Session:
Chronic Myeloid Leukemia - Therapy: Poster I Date & Time:
Saturday, December 7, 2013, 5:30 – 7:30 p.m. Abstract No.: 1483
Presenter: Jorge E. Cortes, M.D. (The University of Texas MD
Anderson Cancer Center) Location: Hall E
Health Economics and Outcomes Research:
Comparative Efficacy after 2G TKIs
Title: Comparative Efficacy among Chronic Phase-Chronic
Myeloid Leukemia (CP-CML) Patients after Failure of 2nd Generation
Tyrosine Kinase Inhibitors (2G TKIs) Poster Session: Chronic
Myeloid Leukemia - Therapy: Poster III Date & Time: Monday,
December 9, 2013, 6:00 – 8:00 p.m. Abstract No.: 4010 Presenter:
Jeff H. Lipton, Ph.D., M.D. (Princess Margaret Hospital, Toronto)
Location: Hall E
Preclinical: Potency of Ponatinib and
Other Approved TKIs
Title: Comprehensive Analysis of the In Vitro Potency of
Ponatinib and All Other Approved BCR-ABL TKIs Against a Panel of
Clinically-Relevant Single and Compound BCR-ABL Mutants Poster
Session: Chronic Myeloid Leukemia - Therapy: Poster III Date &
Time: Monday, December 9, 2013, 6:00 – 8:00 p.m. Abstract No.: 3992
Presenter: Joseph M. Gozgit, Ph.D. (ARIAD Pharmaceuticals, Inc.)
Location: Hall E
About ARIAD
ARIAD Pharmaceuticals, Inc., headquartered in Cambridge,
Massachusetts and Lausanne, Switzerland, is an integrated global
oncology company focused on transforming the lives of cancer
patients with breakthrough medicines. ARIAD is working on new
medicines to advance the treatment of various forms of chronic and
acute leukemia, lung cancer and other difficult-to-treat cancers.
ARIAD utilizes computational and structural approaches to design
small-molecule drugs that overcome resistance to existing cancer
medicines. For additional information, visit http://www.ariad.com
or follow ARIAD on Twitter (@ARIADPharm).
ARIAD PharmaceuticalsFor InvestorsKendra Adams,
617-503-7028Kendra.adams@ariad.comorFor MediaLiza Heapes,
617-621-2315Liza.heapes@ariad.com
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