Item 1.01 Entry Into a Material Definitive
Agreement.
On November 21, 2019, Bio-Path Holdings,
Inc. (the “Company”) and several institutional investors entered into securities purchase agreements (the “Purchase
Agreements”), pursuant to which the Company agreed to sell, in a registered direct offering (the “Registered Direct
Offering”), an aggregate of 808,080 shares (the “Shares”) of its common stock, par value $0.001 per share (“Common
Stock”), and warrants to purchase up to 606,060 shares of Common Stock (the “Investor Warrants”) for a purchase
price of $9.90 per Share and accompanying Investor Warrant and gross proceeds of approximately $8.0 million. Subject to certain
ownership limitations, the Investor Warrants will be exercisable immediately upon issuance, have a term of five years from issuance
and have an exercise price of $9.90 per share. The number of shares issuable upon exercise of the Investor Warrants and the exercise
price of the Investor Warrants are adjustable in the event of stock splits, stock dividends, combinations of shares and similar
recapitalization transactions.
On November 20, 2019, the Company entered
into an engagement letter (the “Engagement Letter”) with H.C. Wainwright & Co., LLC (the “Placement Agent”),
pursuant to which the Placement Agent agreed to serve as the exclusive placement agent for the Company, on a reasonable best efforts
basis, in connection with the Registered Direct Offering. The Company has agreed to pay the Placement Agent an aggregate cash fee
equal to 7.0% of the gross proceeds received in the Registered Direct Offering. In addition, the Company has agreed to grant to
the Placement Agent warrants to purchase up to 48,485 shares of Common Stock (the “Placement Agent Warrants”). The
Placement Agent Warrants will be substantially on the same terms as the Investor Warrants, except that the Placement Agent Warrants
will have an exercise price of $12.375 per share and will have a term of five years from the effective date of the Registered Direct
Offering. The Company will also reimburse the Placement Agent $85,000 for non-accountable expenses and $10,000 for clearing expenses.
The Shares, Investor
Warrants, Placement Agent Warrants and the shares issuable upon exercise of the Investor Warrants and Placement Agent Warrants
will be issued pursuant to a prospectus supplement dated as of November 21, 2019, which was filed with the Securities and Exchange
Commission in connection with a takedown from the Company’s shelf registration statement on Form S-3 (File No. 333-231537),
which became effective on June 5, 2019, and the base prospectus dated as of June 5, 2019 contained in such registration statement.
The net proceeds to the Company from the
Registered Direct Offering, after deducting the Placement Agent’s fees and expenses and the Company’s estimated offering
expenses, and excluding the proceeds, if any, from the exercise of the Investor Warrants and the Placement Agent Warrants, are
expected to be approximately $7.3 million. The Registered Direct Offering is expected to close on or about November 25, 2019, subject
to the satisfaction of customary closing conditions. The Company currently intends to use these net proceeds for working capital
and general corporate purposes.
The legal opinion of Winstead PC relating
to the legality of the issuance and sale of the Shares, Investor Warrants, Placement Agent Warrants and the shares issuable upon
exercise of the Investor Warrants and Placement Agent Warrants in the Registered Direct Offering is attached as Exhibit 5.1 to
this Current Report on Form 8-K.
The description of terms and conditions
of the Engagement Letter, the form of Purchase Agreement, the form of Investor Warrant and the form of Placement Agent Warrant
set forth herein do not purport to be complete and are qualified in their entirety by the full text of the Engagement Letter,
the form of Purchase Agreement and the form of Placement Agent Warrant, which are attached hereto as Exhibits 99.1, 10.1, 4.1
and 4.2, respectively.