vTv to Host Key Opinion Leader Event to Discuss the Type 1 Diabetes Treatment Landscape and Emerging Therapies as Adjuncts to...
October 03 2019 - 7:30AM
vTv Therapeutics Inc. (Nasdaq: VTVT), today announced that the
Company will host a key opinion leader (KOL) presentation and
webcast discussing the type 1 diabetes (T1D) treatment landscape
and emerging therapies in New York City on Tuesday,
October 8, 2019 from 8:30 am to 10:00 am ET.
The event will highlight the current treatment landscape in T1D
and unmet need for additional therapies, with a focus on treatment
adjuncts to insulin. vTv Therapeutics will also provide a
brief overview and update on the company's ongoing Phase 2 clinical
trial, the Simplici-T1 study, evaluating TTP399, a liver-selective
Glucokinase Activator, as an add-on to insulin therapy for patients
with T1D.
To register to attend the event, contact Mike
Biega, Trout Group: mbiega@troutgroup.com or register
here. Advanced registration is required, as space is limited.
A live webcast of the event will be available here and can also
be found on the Investor page of vTv’s website
at www.vtvtherapeutics.com. The archived version of the
webcast will be available for replay on the Webcasts section
of the Investors page of vTv Therapeutics’ website for 90 days
following the event.
Featured Speakers:
- John B. Buse, MD, PhDVerne S. Caviness Distinguished
ProfessorChief, Division of EndocrinologyDirector, Diabetes
CenterDirector, NC Translational and Clinical Sciences
InstituteExecutive Associate Dean, Clinical ResearchUniversity of
North Carolina School of Medicine
- Kevan C. Herold, MDProfessor of Immunobiology and Internal
MedicineDeputy Director, Yale Center for Clinical InvestigationYale
University
- Esther Latres, PhDDirector, Research, JDRF
About the Simplici-T1 Study:
Simplici-T1 is a multi-center, randomized, double-blind,
adaptive study assessing the pharmacokinetics, pharmacodynamics,
safety and tolerability of TTP399 as an adjunct to insulin therapy
in adult patients with T1D. The study is being conducted with
support from JDRF, the leading global organization funding research
in type 1 diabetes.
The Phase 2 learn-and-confirm study is being conducted in two
parts to evaluate the safety and efficacy of TTP399 in T1D patients
over twelve weeks of daily dosing. Part 1 enrolled 19 patients on
both insulin pumps and continuous glucose monitors (CGMs). The
topline results from Phase 2 - Part 1 were reported in June
2019:
- The study met its primary endpoint of change in A1c from
baseline after 12 weeks of treatment. Patients treated with TTP399
(n=8) showed a statistically significant mean reduction in HbA1c of
0.7% (p=0.03) at 12 weeks relative to the placebo group
(n=11).
- TTP399 was well tolerated with similar incidences of
treatment-emergent adverse events overall and by system organ
class. The study had neither a serious adverse event nor an
incident of diabetic ketoacidosis reported.
Part 2 is now fully-enrolled with patients utilizing a treatment
regimen that includes either insulin pumps or multiple daily
injection therapy, with CGMs optional. Topline results from the
study are expected in the first quarter of 2020.
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical
company focused on developing oral small molecule drug candidates.
vTv has a pipeline of clinical drug candidates led by programs for
the treatment of diabetes, Alzheimer’s disease, and inflammatory
disorders. vTv’s development partners are pursuing additional
indications in type 2 diabetes, chronic obstructive pulmonary
disease (COPD), and genetic mitochondrial diseases.
Forward-Looking Statements
This release contains forward-looking statements, which involve
risks and uncertainties. These forward-looking statements can be
identified by the use of forward-looking terminology, including the
terms “anticipate,” “believe,” “could,” “estimate,” “expect,”
“intend,” “may,” “plan,” “potential,” “predict,” “project,”
“should,” “target,” “will,” “would” and, in each case, their
negative or other various or comparable terminology. All statements
other than statements of historical facts contained in this
release, including statements regarding the timing of our clinical
trials, our strategy, future operations, future financial position,
future revenue, projected costs, prospects, plans, objectives of
management and expected market growth are forward-looking
statements. These statements involve known and unknown risks,
uncertainties and other important factors that may cause our actual
results, performance or achievements to be materially different
from any future results, performance or achievements expressed or
implied by the forward-looking statements. Important factors that
could cause our results to vary from expectations include those
described under the heading “Risk Factors” in our Annual Report on
Form 10-K and our other filings with the SEC. These forward-looking
statements reflect our views with respect to future events as of
the date of this release and are based on assumptions and subject
to risks and uncertainties. Given these uncertainties, you should
not place undue reliance on these forward-looking statements. These
forward-looking statements represent our estimates and assumptions
only as of the date of this release and, except as required by law,
we undertake no obligation to update or review publicly any
forward-looking statements, whether as a result of new information,
future events or otherwise after the date of this release. We
anticipate that subsequent events and developments will cause our
views to change. Our forward-looking statements do not reflect the
potential impact of any future acquisitions, merger, dispositions,
joint ventures or investments we may undertake. We qualify all of
our forward-looking statements by these cautionary statements.
ContactsInvestors: vTv Therapeutics Inc.
IR@vtvtherapeutics.com
or Media:Josh Vlasto212-572-5969PR@vtvtherapeutics.com
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