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This Schedule 13G is being jointly filed by Partner Fund Management, L.P. (“PFM”), Partner
Fund Management GP, LLC (“PFM-GP”), Partner Investment Management, L.P. (“PIM”), Partner Investment Management
GP, LLC (“PIM-GP”), Brian D. Grossman (“Grossman”) and Christopher M. James (“James” and, collectively
with PFM, PFM-GP, PIM, PIM-GP and Grossman, the “Reporting Persons”) with respect to shares of common stock (and
options to purchase and/or other securities convertible into common stock) of the above-named issuer owned by PFM Healthcare
Master Fund, L.P., a Cayman Islands limited partnership (“HCM”), PFM Healthcare Opportunities Master Fund, L.P., a
Cayman Islands limited partnership (“HCOPP”), PFM Healthcare Principals Fund, L.P., a Delaware limited partnership
(“HCP”), PFM Healthcare Emerging Growth Master Fund, L.P., a Cayman Islands limited partnership (“HEGM”),
PFM Global Long Alpha Master Fund, L.P., a Cayman Islands limited partnership (“GLAM”), PFM Diversified Principals
Fund, L.P., a Delaware limited partnership (“DP”), PFM Diversified Master Fund, L.P., a Cayman Islands limited partnership
(“DM”), and PFM Diversified Institutional Master Fund, L.P., a Cayman Islands limited partnership (“DI”and,
collectively with HCM, HCOPP, HCP, HEGM, GLAM, DP and DM, the “Funds”).
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PFM is the investment advisor for HCM, HCOPP, HEGM, GLAM, DM and DI. PIM is the investment
advisor for HCP and DP. PFM-GP and PIM-GP are, respectively, the general partners of PFM and PIM. Grossman is the
portfolio manager for the health care strategy for the Funds. James is the portfolio manager for the diversified strategy for
the Funds. Grossman and James are co-managing members of PFM-GP and PIM-GP.
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