UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 6-K
REPORT OF
FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13A-16 OR
15D-16 UNDER THE
SECURITIES EXCHANGE ACT OF 1934
Dated November 25, 2015
Commission File Number 001-35428
PRIMA BIOMED LTD
(Exact Name as Specified in its Charter)
N/A
(Translation of Registrants Name)
Level 7, 151 Macquarie Street
Sydney, 2000 New South Wales, Australia
(Address of principal executive office)
Indicate by
check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.
Form
20-F x Form 40-F ¨
Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b) (1): ¨
Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by
Regulation S-T Rule 101(b) (7): ¨
Indicate by check mark whether by furnishing the information contained in this Form, the registrant is also thereby furnishing the information
to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
Yes ¨ No
x
If Yes is marked, indicate below the file number assigned to the
registrant in connection with Rule 12g3-2(b): Not applicable.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned, thereunto duly authorized.
Dated: November 25, 2015
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Prima BioMed Ltd |
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By: |
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/s/ Marc Voigt |
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Name: |
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Marc Voigt |
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Title: |
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Chief Executive Officer |
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EXHIBIT INDEX
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Exhibit |
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Description of Exhibit |
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99.1 |
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Prima BioMed Ltd 2015 Annual General Meeting Address by Russell Howard, Non-Executive Director |
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99.2 |
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Annual General Meeting CEO Presentation |
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Exhibit 99.1
Prima BioMed Ltd
2015 Annual General Meeting
Address by Russell Howard,
Non-Executive Director
Dear Fellow Shareholder,
On
behalf of our Board, I would like to welcome you to the Prima BioMed Annual General Meeting for 2015. Primas Chair, Lucy Turnbull and Deputy Chair, Albert Wong both send their apologies that they are unable to attend todays meeting. This
is due to unavoidable international travel commitments.
The Board is delighted that Lucy is standing for re-election. Despite her considerable new
responsibilities, she remains committed to development of Primas immunotherapy products for the benefit of cancer patients, as well as Prima shareholders. Lucy has made a highly valued contribution to the Board over the past 5 years. We have
her ongoing support and counsel going forward.
This past year embodies some of the most significant events in Primas history. Most notably, these
were the Immutep acquisition in December 2014 and the subsequent unveiling of the AIPAC clinical trial for our lead product IMP321 in metastatic breast cancer in conjunction with chemotherapy Paclitaxel.
We welcomed US healthcare investor Ridgeback Capitals A$15 million investment in our Company, as approved by shareholders at our July EGM. In parallel,
we raised A$10 million through a Share Purchase Plan for existing shareholders, for which there was overwhelming demand. On both counts, we appreciate your continued support, affirming our belief that shareholders appreciate the value embedded in
our portfolio of immunotherapy assets.
Along with the Ridgeback investment, these assets are attracting a lot of attention from other investors. We were
pleased to raise a further A$3.55 million through two separate placements to European and Australian funds. These follow the introduction by the ASX of new Listing Rule 7.1A, part of a package of amendments to strengthen Australias equity
capital markets.
The rule provides the ability to increase a companys placement capacity, recognizing the importance of equity placements as a
capital raising mechanism for small- and mid-cap companies. An ASX consultation paper released last month states that the rule has been well received by small and mid-cap companies and their investors, providing valuable assistance during a
period when uncertainty in equity markets made capital raising challenging.
Collectively, the funds raised will support Primas operations
into 2017 and leave us well positioned financially to commence two studies of IMP321 over the next few months. Firstly the AIPAC clinical trial, which I have mentioned and which recently received Scientific Advice from the European Medicines Agency;
and secondly a Phase I trial with IMP321 in combination with a checkpoint inhibitor in melanoma.
The Phase I trial will be started in Queensland.
Queensland has one of the highest instances of melanoma in the world. We are pleased once again to be running clinical trials in Australia, with the first patients expected to be enrolled early next year.
I would like to thank our CEO, Marc Voigt and his team for their extensive efforts in realizing the potential of
IMP321 and our other programs. Today, Prima is in a strong position clinically, commercially and financially. We look forward to reporting on further progress in the year ahead.
Yours sincerely,
Russell Howard
Non-Executive
Director
Prima BioMed
Exhibit 99.2
Prima BioMed
Annual General Meeting CEO
Presentation
November 25, 2015
ASX:PRR; NASDAQ:PBMD
Notice: Forward Looking Statements
The purpose of
the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or
clarification. Accordingly, these slides and the information they contain should be read in conjunction with past and future announcements made by Prima BioMed and should not be relied upon as an independent source of information. Please refer to
the Companys website and/or the
Companys filings to the ASX and SEC for further information.
The views expressed in this presentation contain information derived from publicly available sources that have
not been independently verified. No representation or warranty is made as to the accuracy, completeness or reliability of the information. Any forward looking statements in this presentation have been prepared on the basis of a number of assumptions
which may prove incorrect and the current intentions, plans, expectations and beliefs about future events are subject to risks, uncertainties and other factors, many of which are outside Prima BioMeds control. Important factors that could
cause actual results to differ materially from assumptions or expectations expressed or implied in this presentation include known and unknown risks. Because actual results could differ materially to assumptions made and Prima BioMeds current
intentions, plans, expectations and beliefs about the future, you are urged to view all forward looking statements contained in this presentation with caution. This presentation should not be relied on as a recommendation or forecast by Prima
BioMed. Nothing in this presentation should be construed as either an offer to sell or a solicitation of an offer to buy or sell shares in any jurisdiction.
2
2015 Highlights a Transformative
Year!
Planning of 2 new trials EMA scientific advice
Announcement of Final CVacTM OS data
Ridgeback $15M placement
SPP $10M placement
Partners beginning trials (GSK and Novartis)
New patent filings
New Collaborations NEC/Yamaguchi
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We have raised Primas market profile
Institutional and
Improved independent sell-side
market interest
standing
Active
marketing of
the new
Prima story
Our stock is now actively traded in the US
20
18
(million) 16
day 14
per 12 Nasdaq ASX
traded 10
8
shares 6
.
Ord 4
2
0
Jan-15 Oct-15
5
Prima attracting institutional grade
Market cap
now >US$70m Specialist healthcare funds now on register ~30% of stock now held in ADRs
% of Prima
shares held in ADRs
0% 5% 10% 15% 20% 25% 30% 35%
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Prima SP YTD benchmark
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Participation at Investor and Industry Events
Multiple Roadshows
Investor JP Morgan Jan 2015
Bioshares July 2015
Meetings Rodman & Renshaw Sep 2015
Leerink Sept 2015
Business AusBiotech Oct 2015
BioEurope Nov 2015
Development Multiple other contacts
Scientific ASCO May 2015
SITC Nov 2015
Conferences Checkpoint Conf Nov 2015
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Technology
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Immune Checkpoints
Checkpoints are hot
Prof Frédéric Triebel interviewed about LAG-3 in Nature Biotechnology interview published July 2015
(Volume 15pp673-675)
Immune checkpoints are
junctions in immune signalling mechanisms between cells where decisions are made make good targets for therapies
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IMP321
Soluble dimeric recombinant form of LAG-3
(fusion protein)
IMP321 binds to MHC class II on monocytes
DC/ monocyte activation induced
Leads to T cell expansion and proliferation
Highly efficacious in multiple animal models of cancer and infectious disease Shown to be safe, non-immunogenic and
efficacious in humans At low doses can be used as a T cell adjuvant for cancer vaccines
(Clin Cancer Res. 2008
Jun 1;14(11):3545-54)
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Chemo-Immunotherapy: IMP321
Treatment of cancer
cells with chemotherapy, radiotherapy or other drugs will kill off the cells causing tumour debris to be created and antigen release.
Adding an APC activator like IMP321 post cancer treatment enhances antigen uptake by APCs.
They then migrate to lymph nodes and present a wide range of cancer antigens to CD8 T cells which then actively seek and destroy tumours.
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Other Applications: IMP321
IMP321 can be combined
with other immune checkpoint treatments to help drive optimal immune responses to cancer (eg upcoming combo study)
IMP321 can be used as an adjuvant in vaccine combination studies where it helps to boost the magnitude of an antigen specific response (e.g. NEC/Yamaguchi collaboration)
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Upcoming trials
AIPAC
Ph I Combo pilot
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Planned Phase IIb Chemoimmunotherapy in MBC: AIPAC trial
Multicentre, randomised, double blind, placebo-controlled
15 + 196 patients: IMP321 + paclitaxel vs. paclitaxel + placebo
Primary objective: efficacy (as Progression-Free Survival)
Scientific advice from EMA received in July 2015
Trial initiation expected in Q4 2015
Belgium regulatory approval received in October 2015
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Planned Phase I Study in Immuno-Oncology Combination
Multicentre, open label, dose escalation
Up to 30
patients with unresectable or metastatic melanoma
IMP321 + Anti-PD-1 combination study
Primary objective: safety, tolerability
Trial initiation expected in Q1 2016
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Major Addressable Markets in MBC
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Metastatic Breast Cancer
Annual global incidence
of 1.67M new cases of all breast cancer
Standard of care is variable but includes hormone therapy,
chemotherapy and targeted therapies.
We are specifically targeting Her2- cancer; refractory to hormone
therapy.
Five year survival rate is 22% (American Cancer Society)
Sales of all breast cancer drugs are estimated to grow from $9.8Bn to $18.2Bn/year by 2023
(Pharmatimes, 2015)
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Partnership Updates
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IMP731
for Autoimmune Diseases
GSKs investigational product, GSK2831781, which is derived from IMP731 antibody, aims to kill the few activated LAG-
3+ T cells that are auto-reactive in autoimmune disease leading to long term disease control without
generalised immune suppression
GlaxoSmithKline holds exclusive WW rights to IMP731
Jan 2015: Prima announced a single-digit million US$ milestone
Up to ?64m in total upfront and milestones + royalties
GSK2831781 in Phase I trials with potential regulatory filing expected within 2021-2025 timeframe (See from slide 108 of
GSK investor presentation
Phase II expected to initiate in 2016
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IMP701: Antagonist mAb
IMP701 is an anti-LAG-3
antibody that blocks LAG-
3-mediated immune down-regulation
LAG-3 is a prime target for immune checkpoint blockade as it is readily expressed at a high level in many human tumours.
Novartis holds exclusive WW rights
Aug 2015: Start of Phase 1 study by Novartis (Novartis milestone payment to be received for IMP701 Phase 1 initiation)
LAG-525 to be used in combination with PD-1 in solid tumours before end of this year (See slide 10 of Novartis IR
presentation )
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Other Partnerships
Eddingpharm
NEC/
Yamaguchi
University
Neopharm for CVac
R&D to support new patent filings
CRO and
data managers for clinical trials
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Upcoming Milestones
Clinical
Q4 2015: Initiation of AIPAC (metastatic breast cancer) // First data in 2016 (e.g. safety/PK)
Q1 2016: Initiation of Anti-PD-1 combination Phase I study (melanoma) // First data in
2016(e.g. safety/PK)
Expected commencement of Phase II study with IMP731 (GSK)
Continued development of Phase I study IMP701 (Novartis)
Other
Ongoing discussions re CVac
Strategic partnering and collaboration discussions re IMP321
Progress in IP
Ongoing investor relations efforts
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A solid foundation
Hot
Space
Institutional Investment
First class partnerships
Experienced global team
Robust science
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NASDAQ: PBMD, ASX: PRR
Thank you!
25
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