By Dan Molinski 

Weatherford International, one of the biggest oil-field service companies in the world, will lay off 5,000 employees during the first quarter as it tries to cope with a sharp downturn in energy prices.

The company said late Wednesday that 85%, or 4,250 of the jobs lost, will come in the Western Hemisphere. The move is expected to save the company $350 million annually, Weatherford management said late Wednesday while announcing financial results for 2014.

"We are ready to react swiftly to a dramatically changing landscape," Chief Executive Bernard J. Duroc-Danner said.

In addition, the company is offering voluntary buyouts to certain eligible employees to further reduce its head count. Weatherford's extensive job cuts amount to 9% of its global workforce.

Oil prices have plunged more than 50% since June, putting Weatherford and its peers on the ropes. Oil-field service companies help energy companies drill new oil and gas wells, but falling prices have jeopardized much of the sector's plans for this year. That means Weatherford and rivals, including Schlumberger Ltd. and Halliburton Co., are experiencing a contraction in their business.

Mr. Duroc-Danner said the company's focus will be to ensure Weatherford is cash-flow positive in 2015.

"This means that for every dollar of revenue we lose due to reduced activity and pricing, we will make up for it in cost, capital expenditure and working capital reductions," he said. "Our team will be focused on swift market responsiveness."

Schlumberger, the biggest oil-field service company, said in January it would lay off 9,000 employees, or 7% of its workforce. Halliburton and Baker Hughes Inc. also have announced job cuts in the thousands.

Weatherford has been shedding noncore businesses, cutting costs and laying off workers as plunging oil prices have taken a toll on oil producers and oil-field services providers.

Last year, it raised about $1.8 billion in cash, the bulk of which, it said, it would use to pay down debt.

In the most recent period, Weatherford said it had lowered its net debt to $7.05 billion as of Dec. 31 from $8.14 billion at the end of the previous period.

Weatherford, meanwhile, said that its quarterly loss widened while its revenue declined slightly. The company's bottom line edged analysts' expectations, while the top line fell well short of them.

Overall, Weatherford, reported a loss of $475 million, or 61 cents a share, compared with a year-ago loss of $271 million, or 35 cents a share. Excluding certain items, per-share earnings remained flat at 32 cents.

Revenue slipped to $3.73 billion from $3.74 billion.

Analysts surveyed by Thomson Reuters were expecting 31 cents a share on $3.89 billion of revenue.

In the latest period, North American operations, which accounts for the bulk of the company's revenue, posted a 13% increase from the year-ago period.

Meanwhile, the Middle East, North Africa and Asia, reported a 8.4% drop in revenue; Europe saw a 24% decline; and Latin America a 3.5% increase, the company said.

Maria Armental and Michael Calia contributed to this article.

Write to Dan Molinski at dan.molinski@wsj.com

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