Study Featuring Cleveland Clinic Data
Underscores the Importance of Treating Obesity as a Chronic
Disease
ORLANDO,
Fla., June 21, 2024 /PRNewswire/ -- Today,
data from a retrospective observational study conducted using the
electronic health record at the Cleveland Clinic, shows that
real-world weight loss can be associated with a reduced risk of
obesity-related cancers. The findings were presented as a
Late-Breaking Poster at the 84th Scientific Sessions of
the American Diabetes Association® (ADA) in Orlando, FL.
Overall, 78% of people with diabetes have clinical obesity.
Obesity is linked to higher risks of at least 13 types of cancer
due to excess estrogen and elevated insulin, including breast,
kidney, ovary, liver, and pancreatic cancer. There is an increased
need to further understand the association between diabetes,
obesity, and cancer and corresponding treatments.
The study included a total of 172 patients including 100,143 in
the control arm and 5,329 cases. The median body mass index (BMI at
censoring (kg/m2.) was 34.2 for cases and 34.5 for
controls, which are considered to have obesity according to the
Centers for Disease Control and Prevention (CDC). The association
between the percentage change in body mass index (BMI) with three,
five, and 10-year intervals prior to cancer diagnosis (for cases)
versus controls for each cancer endpoint was assessed using
logistic regression models. The primary endpoint of this study
shows 13 obesity-related cancers found. The secondary endpoint of
this study was highlighted with the occurrence of 16 other types of
cancer including melanoma and other skin malignancies as well as
cancers related to the urinary tract, hematopoietic and
lymphoid tissues, respiratory and intrathoracic organs, male
genital organs, female genital organs, eye, brain and other parts
of the central nervous system, and digestive organs.
In this study, data shows that real-world weight loss is
associated with a reduced risk of obesity-related cancers. The
results show a reduced risk of developing obesity-related cancers
with weight loss at three years (OR 0.99, 95%CI [0.984, 0.996]) and
five years (OR 0.989,95% CI [0.983-0.995]), and for other types of
cancer for all time intervals (ORs<1, P <0.001). The risk was
reduced for renal cell carcinoma (three years), multiple myeloma
(10 years), and endometrial cancer (three and five years) among
primary cancer endpoints (P<0.05).
"This study reinforces how crucial it is to treat obesity as a
chronic disease," said Kenda Alkwatli, MD, Clinical Fellow at
Cleveland Clinic, and author of study. "We are hopeful that these
results can help us better understand how we can use weight loss to
address comorbidities including cancer in patients with
obesity."
This study is an example of why more research is needed to
determine whether cancer risk is influenced by the amount, rate,
and method of weight loss. Future studies will focus on and test to
see if specific anti-obesity medications can reduce cancer
risk.
Research presentation details:
Dr. Alkwatli will
present the findings at the following session:
- Late-Breaking Poster:
Reduced Risk of Obesity-Related Cancers with Real-World Weight
Loss
- Session: Saturday, June 22, 2024
from 12:30-1:00 PM EDT (Late Breaking
Poster Session)
About the American Diabetes Association's Scientific
Sessions
The ADA's 84th Scientific Sessions, the world's
largest scientific meeting focused on diabetes research,
prevention, and care, will be held in Orlando, FL on June
21-24. More than 11,000 leading physicians, scientists, and
health care professionals from around the world are expected to
convene both in person and virtually to unveil cutting-edge
research, treatment recommendations, and advances toward a cure for
diabetes. Attendees will receive exclusive access to thousands of
original research presentations and take part in provocative and
engaging exchanges with leading diabetes experts. Join the
Scientific Sessions conversation on social media using
#ADAScientificSessions.
About the American Diabetes Association
The American
Diabetes Association (ADA) is the nation's leading voluntary health
organization fighting to bend the curve on the diabetes epidemic
and help people living with diabetes thrive. For 83 years, the ADA
has driven discovery and research to treat, manage, and prevent
diabetes while working relentlessly for a cure. Through advocacy,
program development, and education we aim to improve the quality of
life for the over 136 million Americans living with diabetes or
prediabetes. Diabetes has brought us together. What we do next will
make us Connected for Life®. To learn more or to get involved,
visit us at diabetes.org or call 1-800-DIABETES
(1-800-342-2383). Join the fight with us on Facebook (American
Diabetes Association), Spanish Facebook (Asociación Americana de la
Diabetes), LinkedIn (American Diabetes Association), Twitter
(@AmDiabetesAssn), and Instagram
(@AmDiabetesAssn).
Amy Robinson
arobinson@brgcommunications.com
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SOURCE American Diabetes Association