Ciphergen Reports Novel Approach to Detect Cancer by Using SELDI-TOF-MS to Measure Fragments of Host Response Proteins
June 14 2005 - 10:00AM
PR Newswire (US)
Ciphergen Reports Novel Approach to Detect Cancer by Using
SELDI-TOF-MS to Measure Fragments of Host Response Proteins
Findings Published in International Journal of Cancer FREMONT,
Calif., June 14 /PRNewswire-FirstCall/ -- Ciphergen Diagnostics, a
division of Ciphergen Biosystems, Inc. (NASDAQ:CIPH) announced
today a publication in the International Journal of Cancer (115,
783-789) of findings suggesting that Surface Enhanced Laser
Desorption/Ionization Time of Flight Mass Spectrometry
(SELDI-TOF-MS) based immunologic and chromatographic assays can be
used to detect and quantitatively assay for post-translationally
modified forms of host response proteins, which may aid in the
classification of cancer. Although all cancer types generate a host
response, this paper demonstrated that different cancers activate
different subsets of host response proteins. By using Ciphergen's
proprietary SELDI-based Pattern Track(TM) biomarker discovery to
assay process with multivariate bioinformatics tools, multi-marker
assays were generated that could help classify four different types
of cancers, including breast, ovarian, colon, and prostate. This
study was performed in collaboration with scientists at the Johns
Hopkins University School of Medicine. Ciphergen and the Johns
Hopkins University School of Medicine published in Cancer Research
in August 2004 a 503-patient study which revealed 3 novel
biomarkers that could distinguish patients with early stage ovarian
cancer from control individuals (benign disease and healthy women).
The three biomarkers were apolipoprotein A1, a modified form of
transthyretin, and a fragment of ITIH4. The parent forms of these
proteins are each host response proteins. This new publication
demonstrates that the relative abundance of the modified forms of
these host response proteins is tumor type specific. Multivariate
analysis can be applied to these variable modifications as detected
by SELDI-TOF-MS, permitting better classification of cancer. This
approach may be particularly suited to improving the detection of
early stage cancer because it utilizes the body's host response as
an amplified signal elicited by very small tumors. Ciphergen has
termed this process host response protein amplification cascade
(HRPAC), since the process of synthesis, posttranslational
modification and metabolism of host response proteins amplifies the
signal of potentially low-abundant biologically active disease
markers such as enzymes. "We believe that the host response protein
amplification cascade may be a viable alternative to searching for
the elusive highly-specific classical tumor marker. While classical
tumor markers depend on adequate tumor bulk to be detected, HRPAC
amplifies signals generated by even the smallest tumors," stated
Dr. Eric Fung, Vice President of Clinical Affairs. "Because most
other diseases also elicit a host response, we are studying whether
this phenomenon can be used to detect other conditions such as
Alzheimer's disease, infectious disease and cardiovascular disease
in their earliest stages." "The HRPAC mechanism highlights the
potential importance of protein fragments in biomarker discovery
and development of high predictivity biomarker assays for early
diagnosis of disease," commented Gail Page, President of
Ciphergen's Diagnostics Division. About Ciphergen Ciphergen's
Diagnostics Division is dedicated to the discovery of protein
biomarkers and panels of biomarkers and their development into
protein molecular diagnostic tests that improve patient care; and
to providing collaborative R&D services through its Biomarker
Discovery Centers(R) for biomarker discovery for new diagnostic
tests as well as pharmacoproteomic services for improved drug
toxicology, efficacy and theranostic assays. Ciphergen's Biosystems
Division develops, manufactures and markets a family of
ProteinChip(R) Systems and services for clinical, research, and
process proteomics applications. ProteinChip Systems enable protein
discovery, characterization, identification and assay development
to provide researchers with predictive, multi-marker assay
capabilities and a better understanding of biological function at
the protein level. Additional information about Ciphergen can be
found at http://www.ciphergen.com/. Safe Harbor Statement Note
Regarding Forward-Looking Statements: For purposes of the Private
Securities Litigation Reform Act of 1995 (the "Act"), Ciphergen
disclaims any intent or obligation to update these forward-looking
statements, and claims the protection of the Safe Harbor for
forward-looking statements contained in the Act. Examples of such
forward-looking statements include statements regarding the
potential use of host response proteins to aid in the
classification of cancer, the diagnostic tests that Ciphergen
Diagnostics is developing, the predictive diagnostic value of
protein biomarkers, and the expectation that protein multi-marker
tests will improve patient care. Actual results may differ
materially from those projected in such forward-looking statements
due to various factors, including ProteinChip technology's ability
to successfully discover, validate and assay biomarkers and
patterns of biomarkers have diagnostic utility, and our ability to
protect and promote our proprietary technologies. Investors should
consult Ciphergen's filings with the Securities and Exchange
Commission, including its Form 10-Q dated May 10, 2005, for further
information regarding these and other risks of the Company's
business. NOTE: Ciphergen, ProteinChip and Biomarker Discovery
Center are registered trademarks of Ciphergen Biosystems, Inc.
DATASOURCE: Ciphergen Biosystems, Inc. CONTACT: Sue Carruthers,
Investor Relations of Ciphergen Biosystems, Inc., +1-510-505 2233
Web site: http://www.ciphergen.com/
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