Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* Mickle Travis C	2. Issuer Name and Ticker or Trading Symbol KEMPHARM, INC [ KMPH ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President & CEO
(Last) (First) (Middle) C/O KEMPHARM, INC., 1180 CELEBRATION BOULEVARD, SUITE 103	3. Date of Earliest Transaction (MM/DD/YYYY) 8/20/2021
(Street) CELEBRATION, FL 34747 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	8/24/2021		J		96153	D	$0	23354	D
Common Stock	8/24/2021		J		96153	A	$0	96153	I	By Mickle Holdings LLC ⁽¹⁾
Common Stock	8/24/2021		J⁽²⁾		7701	D	$0	0	I	By Travis C. Mickle & Christal M.M. Mickle TRS UA 4-30-09 Mickle Family Trust, co-trustee
Common Stock	8/24/2021		J⁽²⁾		7701	A	$0	31055	D
Common Stock	8/24/2021		J⁽²⁾		1341	D	$0	0	I	By Travis C. Mickle & Christal M.M. Mickle TRS UA 4-30-09 TCM Family Trust, co-trustee
Common Stock	8/24/2021		J⁽²⁾		1341	A	$0	32396	D
Common Stock	8/24/2021		J⁽³⁾		3125	D	$0	29271	D
Common Stock	8/24/2021		J⁽⁴⁾		6287	D	$0	0	D ⁽⁴⁾
Common Stock								15242	I	By Christal M.M. Mickle 2015 Gift Trust dtd 7/21/15, as trustee
Common Stock								9824	I	By Travis C. Mickle 2015 Dynasty Trust dtd 7/21/15, Christal M.M. Mickle as trustee
Common Stock								1034	I ⁽⁵⁾	By Mickle Investments LLC

*Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)*
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Stock Option (right to buy)	$9.06	8/20/2021		A		263743		⁽⁶⁾	8/19/2031	Common Stock	263743	$0	263743	D

Explanation of Responses:
(1)	The Reporting Person is the sole manager member of Mickle Holdings, LLC.
(2)	Transfer of shares held in dissolved trusts to the Reporting Person.
(3)	Transfer of shares to Christal M.M. Mickle.
(4)	Common stock that was previously held jointly by the Reporting Person and Christal M.M. Mickle, and is now held solely by Ms. Mickle.
(5)	The Reporting Person is the sole manager member of Mickle Investments, LLC.
(6)	Grant to the Reporting Person of a stock option under the Issuer's Amended and Restated 2014 Equity Incentive Plan (the "Plan"). 25% of the shares will vest on August 20, 2022 and the remaining 75% of the shares will vest in equal annual installments thereafter, provided that at the relevant vesting dates such optionee's employment relationship has not been terminated as defined in the Plan. All shares underlying the option will vest in full and become immediately exercisable upon a change of control of the Issuer or if the Reporting Person is terminated without cause or resigns for good reason. The option expires ten years after the date of grant.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Mickle Travis C C/O KEMPHARM, INC. 1180 CELEBRATION BOULEVARD, SUITE 103 CELEBRATION, FL 34747	X		President & CEO