Genoptix Inc - Initial Statement of Beneficial Ownership (3)

FORM 3	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0104 Expires: January 31, 2008 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^*

Buono Timothy

2. Date of Event Requiring Statement (MM/DD/YYYY) 10/29/2007

3. Issuer Name and Ticker or Trading Symbol

GENOPTIX INC [GXDX]

(Last) (First) (Middle)

TWO GREENWICH PLAZA, FOURTH FLOOR

4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director ___ X ___ 10% Owner
_____ Officer (give title below) _____ Other (specify below)

(Street)

GREENWICH, CT 06830

(City) (State) (Zip)

5. If Amendment, Date Original Filed (MM/DD/YYYY)

6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	8883	I	See Footnote ⁽¹⁾
Common Stock	4440	I	See Footnote ⁽²⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 4)	2. Date Exercisable and Expiration Date (MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivate Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Series 1-A Preferred Stock	⁽³⁾	⁽³⁾	Common Stock	356154	⁽³⁾	I	See Footnote ⁽⁴⁾
Series 1-B Preferred Stock	⁽⁵⁾	⁽⁵⁾	Common Stock	372348	⁽⁵⁾	I	See Footnote ⁽⁶⁾
Series 1-C Preferred Stock	⁽⁷⁾	⁽⁷⁾	Common Stock	194047	⁽⁷⁾	I	See Footnote ⁽⁸⁾
Series 1-D Preferred Stock	⁽⁹⁾	⁽⁹⁾	Common Stock	227765	⁽⁹⁾	I	See Footnote ⁽¹⁰⁾

Explanation of Responses:
( 1)	Represents shares held by Tullis-Dickerson Capital Focus II, L.P. The Reporting Person may be deemed to have shared voting and dispositive power over the shares beneficially owned by Tullis-Dickerson Capital Focus II, L.P. but disclaims such beneficial ownership, except to the extent of his pecuniary interest therein.
( 2)	Represents shares held by TD Javelin Capital Fund II, L.P. The Reporting Person may be deemed to have shared voting and dispositive power over the shares beneficially owned by TD Javelin Capital Fund II, L.P. but disclaims such beneficial ownership, except to the extent of his pecuniary interest therein.
( 3)	The Series 1-A Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of one share of Common Stock for every 4.75 shares of Series 1-A Preferred Stock, for no additional consideration.
( 4)	See Exhibit 99.
( 5)	The Series 1-B Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of one share of Common Stock for every 4.75 shares of Series 1-B Preferred Stock, for no additional consideration.
( 6)	See Exhibit 99.
( 7)	The Series 1-C Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of one share of Common Stock for every 4.75 shares of Series 1-C Preferred Stock, for no additional consideration.
( 8)	See Exhibit 99.
( 9)	The Series 1-D Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will automatically convert upon the closing of the Issuer's initial public offering, at a conversion ratio of one share of Common Stock for every 4.75 shares of Series 1-D Preferred Stock, for no additional consideration.
( 10)	See Exhibit 99.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Buono Timothy TWO GREENWICH PLAZA FOURTH FLOOR GREENWICH, CT 06830	X	X

Signatures
/s/ Christian V. Kuhlen, attorney-in-fact		10/29/2007
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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