Cardiovascular Systems to Webcast Fiscal 2010 Third-Quarter Earnings Conference Call Wednesday, May 5

Cardiovascular Systems, Inc. (CSI) (Nasdaq: CSII) will host a live webcast of its fiscal 2010 third-quarter conference call on Wednesday, May 5, 2010, at 3:45 p.m. CT (4:45 p.m. ET). David L. Martin, president and chief executive officer, and Laurence L. Betterley, chief financial officer, will discuss the company’s results for its fiscal third quarter ended March 31, 2010, and its financial outlook. The company will issue a post-market earnings release on May 5.

To access the live webcast, go to the investor information section of the company’s website, www.csi360.com, on the day of the conference call and click on the webcast icon. A webcast replay will be available beginning at 7 p.m. CT the same day.

To participate in the conference call, dial (888) 713-4209 and enter 71236627. Please dial in at least 10 minutes prior to the call. To pre-register for the call, log on to the following website: https://www.theconferencingservice.com/prereg/key.process?key=P44YXDQ36. When joining the call, pre-registered participants can enter their PIN code, and other participants can wait for operator assistance.

If you do not have access to the Internet and want to listen to an audio replay of the conference call, dial (888) 286-8010 and enter access number 35324704. The audio replay will be available beginning at 8 p.m. CT on Wednesday, May 5, 2010, through 6 p.m. CT on Friday, May 7, 2010.

About Cardiovascular Systems, Inc.

Cardiovascular Systems Inc., (CSI) (Nasdaq: CSII) based in St. Paul, Minn., is a medical device company focused on providing clinically proven, safe and effective interventional solutions for vascular disease. The company’s Diamondback 360® PAD System removes calcified and fibrotic plaque in small and large peripheral vessels, and addresses many of the limitations associated with existing surgical, catheter and pharmacological treatment alternatives. In August 2007, the U.S. FDA granted 510(k) clearance for the use of the Diamondback 360° as a therapy for PAD, and CSI commenced a U.S. product launch in September 2007. Since then, more than 25,000 procedures have been performed using the system. For more information visit the company’s website at www.csi360.com.

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