Cardiovascular Systems to Webcast Fiscal 2010 First-Quarter Earnings Conference Call Wednesday, November 4

Cardiovascular Systems, Inc. (CSI) (Nasdaq:CSII) will host a live webcast of its fiscal 2010 first-quarter conference call on Wednesday, November 4, 2009, at 3:45 p.m. CT (4:45 p.m. ET). David L. Martin, president and chief executive officer, and Laurence L. Betterley, chief financial officer, will discuss the company’s results for the fiscal first quarter ended September 30, 2009, and its financial outlook. The company will issue a post-market earnings release on November 4.

To access the live webcast, go to the investor information section of the company’s Web site, www.csi360.com, on the day of the conference call and click on the webcast icon. A webcast replay will be available beginning at 7 p.m. CT the same day.

To participate in the conference call, dial (888) 713-4218 and enter 65900739. Please dial in at least 10 minutes prior to the call. To pre-register for the call, log on to the following Web site: https://www.theconferencingservice.com/prereg/key.process?key=PT4BJANPR. When joining the call, pre-registered participants can enter their PIN code and other participants can wait for operator assistance.

If you do not have access to the Internet and want to listen to an audio replay of the conference call, dial (888) 286-8010 and enter access number 72727881. The audio replay will be available beginning at 8 p.m. CT on Wednesday, November 4, 2009, through 6 p.m. CT on Friday, November 6, 2009.

Cardiovascular Systems, Inc., based in St. Paul, Minn., is a medical device company focused on developing and commercializing interventional treatment systems for vascular disease. The company’s Diamondback 360® PAD System is capable of treating a broad range of plaque types both above and below the knee, including calcified lesions, and addresses many of the limitations associated with other treatment alternatives. In August 2007, the U.S. FDA granted 510(k) clearance for the use of the Diamondback 360° as a therapy for peripheral arterial disease. Since then, the Diamondback 360° has been adopted by nearly 600 hospitals across the United States. For more information visit the company’s Web site at www.csi360.com.

About the Diamondback 360® PAD System

CSI’s primary product is the Diamondback 360® PAD System, a minimally invasive catheter system for treating PAD in leg arteries. The Diamondback 360° is highly effective in removing plaque in vessels both below the knee and above the knee in just a few minutes of treatment time. Between 8 million and 12 million Americans suffer from PAD, which is caused by the accumulation of plaque in peripheral arteries (commonly the pelvis or leg) reducing blood flow. Symptoms include leg pain when walking or at rest, and PAD can lead to tissue loss and eventually limb amputation.

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