Waters ACQUITY PREMIER Columns Set a New Standard of Performance for Chromatographic Analyses
October 14 2020 - 8:00AM
Business Wire
Novel Column Technology Designed to Put Disease
Research and Drug Development on More Productive and Efficient
Path
Waters Corporation (NYSE:WAT) today introduced ACQUITY™ PREMIER
Columns, a new family of premium sub-2-micron columns featuring
MaxPeak™ High Performance Surface (HPS) technology. The columns are
for use with any brand of UHPLC system and can measurably improve
data quality by mitigating the loss of sample analytes due to
analyte-to-surface interactions. Designed for the analytical
laboratory seeking to exercise greater control over their
chromatographic separations, the columns improve sample throughput,
assay-to-assay reproducibility and overall confidence in analytical
results.
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Waters ACQUITY PREMIER Columns are ideal
for both small molecule and biopharmaceutical applications. They
are available in various sizes and are manufactured with trusted
sub-2-micron particle technologies; Bridged/Ethyl Hybrid (BEH) for
maximum column stability, Charged Surface Hybrid (CSH) the best
choice for mass spectrometry analysis, and High Strength Silica
(HSS) for increased retention when analyzing challenging polar
compounds. (Photo: Business Wire)
“Analyte loss due to non-specific adsorption is a significant
problem that deserves more attention because of the cost of wasted
effort and lost productivity. Most of the time, scientists don’t
even know what they are missing. There are workarounds but they
come with their own problems,” said Erin Chambers, Vice President,
Chemistry, Waters Corporation. “So we challenged our engineers to
come up with an innovative solution that removes one of the biggest
impediments to getting quality results. Our ACQUITY PREMIER Columns
rectify a problem that has long-plagued chromatography analyses and
enable scientists to create the best quantitative and qualitative
analytical methods whether for discovery, development or quality
control applications.”
Rising to the Challenge
Waters™ ACQUITY PREMIER Columns feature MaxPeak HPS technology,
a hybrid organic/inorganic surface technology that forms a barrier
surface layer between the sample and the stainless steel column.
The benefits of this new technology are many, among them:
- increased sensitivity for low-level, metal-binding analytes
that would otherwise go undetected and unseen
- better all-around peak shapes and peak capacity for more
accurate analyte identification and data interpretation
- greater reproducibility for separations prone to adsorptive
losses meaning less re-work or troubleshooting, and more confidence
in results
Willy Verluyten and Irene Suarez with Janssen Pharmaceutica NV,
Belgium, evaluated the columns for their own methods development
work.
“The Waters ACQUITY PREMIER Peptide BEH C18 300Å Column shows an
excellent degree of specificity and selectivity in denaturing and
non-denaturing analysis of synthetic oligonucleotides, due to the
absence of non-specific binding properties of this new column
hardware in combination with great stationary phase performance,”
says Verluyten. “The Waters ACQUITY PREMIER Column is a
highly-valuable addition to our column test package for the future
development of synthetic oligonucleotides analytical methods.”
From Challenge to Opportunity
The introduction of ACQUITY PREMIER Columns sheds light onto a
well-known problem among scientists: the adsorption of sample
analytes to the interior wall of steel analytical columns. This is
a significant problem when analyzing metal-loving analytes ranging
from organic acids and organophosphates to oligonucleotides,
peptides, glycans and phospholipids. Organizations are known to
spend days and tens of thousands of dollars of precious product
(e.g. oligonucleotides), just to condition an LC column prior to
analysis in order to minimize adsorptive analyte losses.
Kerri Smith, Principal Scientist, at Waters Corporation has
studied organic acid metabolites that play a role in diabetes,
cancer and heritable diseases. “If you lose a low-level analyte
because of analyte-to-metal adsorption, and don’t detect it in its
correct concentration, you’ll never understand if it’s playing an
important role in the disease you are studying,” said Smith.
Waters ACQUITY PREMIER Columns are ideal for both small molecule
and biopharmaceutical applications and are manufactured with
trusted sub-2-micron particle technologies; Bridged/Ethyl Hybrid
(BEH) for maximum column stability, Charged Surface Hybrid (CSH)
the best choice for mass spectrometry analysis, and High Strength
Silica (HSS) for increased retention when analyzing challenging
polar compounds. The columns are now available worldwide from
Waters.
For more information about ACQUITY PREMIER Columns with MaxPeak
HPS, download a free copy of the Waters white paper titled Low
Adsorption UPLC Columns Based on MaxPeak High Performance
Surfaces.
Additional Resources
Learn more about ACQUITY PREMIER Columns from this blog post
Learn more about ACQUITY PREMIER Columns on our web site
Learn more about oligonucleotides analysis from this
applications note
Learn more about peptide analysis from this infographic
About Waters Corporation (www.waters.com)
Waters Corporation (NYSE:WAT), the world's leading specialty
measurement company, has pioneered chromatography, mass
spectrometry, and thermal analysis innovations serving the life,
materials, and food sciences for more than 60 years. With more than
7,000 employees worldwide, Waters operates directly in 35
countries, including 15 manufacturing facilities, and with products
available in more than 100 countries.
Waters, ACQUITY, and MaxPeak are trademarks of Waters
Corporation.
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Brian J. Murphy PR Manager, Corporate Communications Waters
Corporation brian_j_murphy@waters.com +1 508-482-2614
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