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Iovance Biotherapeutics Inc

Iovance Biotherapeutics Inc (IOVA)

1.98
-0.06
(-2.94%)
2.00
0.02
(1.01%)

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Key stats and details

Current Price
2.00
Bid
1.98
Ask
2.00
Volume
11,248,017
1.97 Day's Range 2.088
1.6385 52 Week Range 12.505
Market Cap
Previous Close
2.04
Open
2.07
Last Trade Time
Financial Volume
$ 22,769,131
VWAP
2.0243
Average Volume (3m)
17,101,042
Shares Outstanding
333,934,387
Dividend Yield
-
PE Ratio
-1.77
Earnings Per Share (EPS)
-1.11
Revenue
164.07M
Net Profit
-372.18M

About Iovance Biotherapeutics Inc

Iovance Biotherapeutics Inc is a clinical-stage biopharmaceutical company. The company focused on the development and commercialization of cell therapies as novel cancer immunotherapy products designed to harness the power of a patient's immune system to eradicate cancer cells. Its lead pipeline can... Iovance Biotherapeutics Inc is a clinical-stage biopharmaceutical company. The company focused on the development and commercialization of cell therapies as novel cancer immunotherapy products designed to harness the power of a patient's immune system to eradicate cancer cells. Its lead pipeline candidate, LN-145, is an adoptive cell therapy using tumor-infiltrating lymphocytes to treat patients with refractory metastatic melanoma. Show more

Sector
Biological Pds,ex Diagnstics
Industry
Biological Pds,ex Diagnstics
Website
Headquarters
Camden, Delaware, USA
Founded
-
Iovance Biotherapeutics Inc is listed in the Biological Pds,ex Diagnstics sector of the NASDAQ with ticker IOVA. The last closing price for Iovance Biotherapeutics was $2.04. Over the last year, Iovance Biotherapeutics shares have traded in a share price range of $ 1.6385 to $ 12.505.

Iovance Biotherapeutics currently has 333,934,387 shares outstanding. The market capitalization of Iovance Biotherapeutics is $681.23 million. Iovance Biotherapeutics has a price to earnings ratio (PE ratio) of -1.77.

Iovance Biotherapeutics (IOVA) Options Flow Summary

Overall Flow

Bearish

Net Premium

-48k

Calls / Puts

0.00%

Buys / Sells

0.00%

OTM / ITM

0.00%

Sweeps Ratio

0.00%

IOVA Latest News

PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
1-0.23-10.31390134532.232.311.9594082382.09597476CS
40.317.64705882351.72.471.67118385292.02696317CS
12-1.59-44.28969359333.593.731.6385171010422.2612592CS
26-5.17-72.10599721067.178.151.6385130951683.38811317CS
52-5.82-74.42455242977.8212.5051.638597020495.41897799CS
156-6.87-77.45208568218.8718.331.638569720297.21084362CS
260-28.13-93.362097577230.1354.20811.638550635569.89191924CS

IOVA - Frequently Asked Questions (FAQ)

What is the current Iovance Biotherapeutics share price?
The current share price of Iovance Biotherapeutics is $ 2.00
How many Iovance Biotherapeutics shares are in issue?
Iovance Biotherapeutics has 333,934,387 shares in issue
What is the market cap of Iovance Biotherapeutics?
The market capitalisation of Iovance Biotherapeutics is USD 681.23M
What is the 1 year trading range for Iovance Biotherapeutics share price?
Iovance Biotherapeutics has traded in the range of $ 1.6385 to $ 12.505 during the past year
What is the PE ratio of Iovance Biotherapeutics?
The price to earnings ratio of Iovance Biotherapeutics is -1.77
What is the cash to sales ratio of Iovance Biotherapeutics?
The cash to sales ratio of Iovance Biotherapeutics is 4.01
What is the reporting currency for Iovance Biotherapeutics?
Iovance Biotherapeutics reports financial results in USD
What is the latest annual turnover for Iovance Biotherapeutics?
The latest annual turnover of Iovance Biotherapeutics is USD 164.07M
What is the latest annual profit for Iovance Biotherapeutics?
The latest annual profit of Iovance Biotherapeutics is USD -372.18M
What is the registered address of Iovance Biotherapeutics?
The registered address for Iovance Biotherapeutics is 2140 S DUPONT HWY, CAMDEN, DELAWARE, 19934
What is the Iovance Biotherapeutics website address?
The website address for Iovance Biotherapeutics is www.iovance.com
Which industry sector does Iovance Biotherapeutics operate in?
Iovance Biotherapeutics operates in the BIOLOGICAL PDS,EX DIAGNSTICS sector

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IOVA Discussion

View Posts
Sunman88 Sunman88 5 hours ago
IOvA may be at $1 or lower before l its full approval. Only thing that matters here is IOVAs ability to cut costs drastically, increase revenue to exceed lowered target and NOT dilute shares at the lows. . This is asking a lot. Q2 will provide a nice glimpse. This stock has been played to the ground. Trust score is close to zero.
๐Ÿ‘๏ธ0
surfkast surfkast 6 hours ago
Cutting approval time by months can only be good for IOVA.
Let's see if the market agrees.
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badgerkid badgerkid 13 hours ago
Potentially very good news for Iovance and for nsclc and endo approvals:

https://stocktwits.com/bavariaron/message/618601149

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Sunman88 Sunman88 1 day ago
They analysts are a laughing stock. They are so behind the curve. If you bought based on their recommendation, you are screwed now. Itโ€™s at $2 for many good reasons. Repeated dilutions to ten time of $400M, lies about annual estimates, demand is low, burn rate is through the roof and additional dilutions are now a strong possibility. If they cannot ramp up sales and beat revised estimates hands down in Q2 and Q3, itโ€™s game
over. $1 is more likely.
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surfkast surfkast 1 day ago
Based on 12 Wall Street analysts offering 12 month price targets for Iovance Biotherapeutics in the last 3 months. The average price target is $10.00 with a high forecast of $25.00 and a low forecast of $2.00. The average price target represents a 405.05% change from the last price of $1.98.

7 buy 5 hold 0 sell

https://www.tipranks.com/stocks/iova/forecast
๐Ÿ‘๏ธ0
Sunman88 Sunman88 6 days ago
A year ago, post approval for Amtagvi, share price shot up from $9 to $18. Today it is struggling at $2 mostly due to missed revenue, dilution of shares and loss of trust with current management team. CFO leaving at this juncture is proof positive of chaos. Only hope and prayer is the COO delivers on beating revised forecasts for the next several quarters while burn rate is controlled in a manner to reach breakeven by 2026. This coupled with good news from ongoing studies has the potential to bring the stock back to $9 (market cap $3B) by end of this year or early 2026. However, if they miss revised targets, itโ€™s game over. This is my position and Iโ€™m sticking to it. Good luck to all of us. We need it to get out of this dire state.
👍️ 4
badgerkid badgerkid 7 days ago
From this point forward, what really matters is improving revenues each and every Q for the next several quarters. Despite what's happened in year one, the new CCO Mr. Kirby and his team have to be fully committed to improving the message of the need to have patients start TIL therapy far earlier in their disease progression. The KOL panel said that very same thing in the fireside chat the other day. There's plenty of catalysts for year two, but increasing revenues has to be at the top of the list by far.

Some have speculated that the CFO is leaving (or was asked to leave) due to the botched guidance (or the failure in messaging when it became obvious that guidance wasn't going to be met). It's important to remember that the CFO is only one piece in approving guidance before it goes out to the public. Likely the CEO and some BOD members were also part of that decision. If the CFO is being sacrificed, will there be others?

It's also possible that he's simply moving on as many execs do when they've been in a job for a certain number of years. If they wish to remain relevant, they make those customary job changes multiple times in their careers. Then again, he may simply be going to a job where they understand what he's saying, I always struggled with Jean-Marc's heavy accent on those conference calls.

In the meantime, IOVA is still a victim of the sector and the overall market until such time that they impress with increasing revenues. Q2 is looking like it'll suffice, but I suspect Q3 will finally show those improvements expected with the new CCO at the helm.

Many still want additional new leadership and I can't say that I blame them. Bottom line is the bottom line - revenues need to be increasing. Trusting this company's messaging again will take time.

GL to IOVA longs.
👍️ 2
Hicham007 Hicham007 7 days ago
I am not sure it is a big loss given how they totally missed their FY25 guidance, it might help to restore some confidence between management and shareholders...
👍️ 4
surfkast surfkast 1 week ago
Happens all the time when other opportunities call.
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jondoeuk jondoeuk 1 week ago
CFO resigned https://www.sec.gov/ix?doc=/Archives/edgar/data/0001425205/000110465925059464/tm2517988d1_8k.htm
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badgerkid badgerkid 1 week ago
"I was told I'd die from skin cancer - but my tumour disappeared with new therapy": https://inews.co.uk/news/health/skin-cancer-therapy-tumour-disappear-3726365

โ€œThe study demonstrates that for patients with few options left, a single infusion of lifileucel can provide a deep and lasting response and even complete remission in some cases. This marks a major advance in how we think about treating solid tumours.โ€

The next step is to help the onc docs to see TIL therapy as an earlier option, as a second line, not end of the line. This has shown to be even far more effective than these good results that we already see when used late in the disease progression.

Moving toward approval in foreign markets, numerous centers that did trials will become the first ATCs, centers that already have the experience necessary to hit the ground running.

GL
👍️ 2
badgerkid badgerkid 1 week ago
Jondoeuk, keeping with the goal of limiting off-topic, I chose to remove some posts that open the door to rebuttal. If I let one post stay up, I would need to allow responses which would then take us down that path again that we're trying to avoid.

Have a great day.
👍️ 2
Frankestin Frankestin 1 week ago
👍️ 1
badgerkid badgerkid 1 week ago
Spent a little time digesting the call and the transcript. Dr. Gastman was more conservative and obviously holding back a bit as is necessary when discussing trial data for lung. He can't definitively say without requiring an 8-K, but he most certainly implied that the numbers will be acceptable for the BLA which bodes well for us as shareholders.

Mr. Kirby was as expected, confident and focused. Exactly what I want from a CCO. Sales and marketing needed a lot more than they had previously and Kirby does seem like the real deal. It all depends on how effective they are at communicating with new docs, ATCs, and the entire medical teams necessary to start driving earlier referrals of patients. 3rd line+ is not going to cut it and they know that full well. Iovance needs more patients and earlier line patients to really impress and get that exponential growth that I believe is fully possible.

The big takeaway for me is the one we all know, lung is far bigger than the melanoma market, but melanoma is more than enough to be profitable. The slower start did reveal areas that needed attention but are fully correctible for the future success of Iovance. Melanoma was a great place to start and will make future indications pop much quicker upon their approvals now that many of those early bugs are worked out.

For me, the stock market just doesn't want to reward Iovance's past mistakes until some proof is given over the next couple Q's. Believability is still an issue.

End of the year should be bangin'.

GL to IOVA longs.
👍️ 3
surfkast surfkast 2 weeks ago
Bring back the institutional buyers!

https://www.tipranks.com/stocks/iova/forecast
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badgerkid badgerkid 2 weeks ago
Theorysuit, sorry, but I'm trying to keep off-topic pumping of other companies off this board so I requested removal of the full chain.

Here's hoping we can keep those types of posts to a minimum.
👍️ 4
ducruacuteo11 ducruacuteo11 2 weeks ago
This will get all the bulls excited for years to come.
https://acrobat.adobe.com/id/urn:aaid:sc:VA6C2:8ed05d38-f968-4cc6-a2d7-5db87accc20a
👍️ 3
theorysuit theorysuit 2 weeks ago
Yeah the shorts keep doubling down. 28%. The only thing is that this company has a lot of connections to hedge funds on their board. WR, PD are both connected. We will see.
👍️ 1
surfkast surfkast 2 weeks ago
Well I jumped in nearly today and am already happy. Caught today's low. If nothing else I see the institutions buying and then shorting when it hits say $8- $10
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badgerkid badgerkid 2 weeks ago
Looks like another 9 million added to the short interest as of 5/30/25. It's now up to 86 million shares short.

The recent rally with money returning to biotechs will only be helped by the shorts needing to cover some of their positions.

Shorts become the buyers as I continue to add shares. I guess we're competing for those shares.

GL to IOVA longs.
👍️ 2
badgerkid badgerkid 2 weeks ago
Fireside chat at Goldman Sachs, June 11th, 1:20 pm ET: https://ir.iovance.com/news-releases/news-release-details/iovance-biotherapeutics-present-upcoming-conference
👍️ 2
surfkast surfkast 2 weeks ago
Thanks for the reply!
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badgerkid badgerkid 2 weeks ago
surfkast, there is no perfect reloading zone. You always seemed to struggle with Iovance and have been nothing but frustrated. This may be one of those companies that you just avoid. It's still going to be bumpy for the coming months and years. Management hasn't demonstrated that they have full control of this process yet, so risk is real and I don't know if your heart can take it.

I'm excited about the science. I'm still adding shares. I believe the company is worth more to most any BP that wants to expand into TIL therapy, but I'm not convinced that the current management team is the best choice for shareholders. It may be time to just get the best offer from BP so that the science can fully flourish even though it would only be a minor gain for most of us who are long shares. I'm fairly confident that the minimum value right now is still in the $4-5 billion range ($12-15/share). Many of my friends and I have average cost of shares below $10. Iovance is certainly worth a lot more once they demonstrate control over the manufacturing process with higher success rates and increasing profit margins. I do believe that they're starting to understand the need to be far more aggressive in their selling and marketing due to the complexities of this process and the challenges in the logistics.

I hate saying this because if they could go it alone, meaning they have a handle on how to grow this company properly and efficiently, IOVA could be a major winner with sales exceeding $2 billion in just a few years, and assuming lung approval down the road, $3-4 billion in sales in maybe less than 5 years. IOVA could get to $40-50/share or more with those kinds of numbers.

But my point remains, IOVA may be a bit too much for you to play anymore. It's not going to be an easy ride even if you're cost per share is around $2.

My attitude, if you're going to trade it, then trade it, but if you're going to invest for the long haul, buy now and walk away for 1 year.

Good luck to the longs.
👍 1
surfkast surfkast 2 weeks ago
Did I miss the perfect reloading zone? Do I still jump back in?
๐Ÿ‘๏ธ0
Frankestin Frankestin 2 weeks ago
It's not that I wanted to sell but I had put some high and I didn't think it would get there and above all that it wouldn't come back! Oh well let's celebrate anyway! I still have some, but if it go down, I'll take back some more!
It's nice when insiders buy with their own money!
๐Ÿ‘๏ธ0
Sunman88 Sunman88 2 weeks ago
I agree with everything you have said. Very thoughtful. Hope you are right for our collective good. Letโ€™s enjoy this beautiful sunny weekend! Cheers Badger🥂
👍️ 2
badgerkid badgerkid 2 weeks ago
Friday saw a 5+ million share block of IOVA stock trade in the after hours. Any thoughts?

Kirby, the CCO, did buy 30k shares himself in the open market the day prior: https://ir.iovance.com/static-files/20026620-7f04-474c-a36a-f87af3132207

https://ir.iovance.com/sec-filings/sec-filing/4/0001104659-25-057310

Feel free to read the Insider Trading Policy for Iovance (but it still won't guarantee that you'll understand why insiders buy or don't buy): https://www.sec.gov/Archives/edgar/data/1425205/000155837025001834/iova-20241231xex19d1.htm
👍️ 1
badgerkid badgerkid 2 weeks ago
Sunman, I still don't see the game the same way as you, but we're both taking this ride. I do agree that there were too many missteps and credibility is a hard thing to regain. I'm of the belief that the company is doing the right things now to correct for some of their past mistakes. For both our sakes, I hope I'm right and the company is learning and improving, and that your wrong regarding a plan to take this company private on the cheap.

We're riding together regardless so here's hoping for getting their act together and treating and ultimately helping and healing a great number of patients going forward.

The one thing we share in common is a belief in the science of TIL therapy being a very good option for a vast number of cancer patients.

I certainly hope we're not being played, and fwiw, I don't think we are. I think much of the guidance snafu was due to overzealous expectations that the initial ramp would go close to perfect. Failing to adjust for that overstatement sooner (or not even guiding) is still going to be a tough loss of confidence to overcome. Increasing revenues, margins, and successful new applications can cure a lot of our current concerns most certainly.

GL to us.
👍️ 1
Sunman88 Sunman88 2 weeks ago
One year ago at this time it was at $18. Today, $2 makes you excited and you refer to it as a breakthrough!
The current interim CEO and his top line management team have lost credibility. Share price close to cash says it all. It remains under pressure and the ONLY way out of this mess is a blockbuster Q2 and Q3.
Firing of the CEO has a strong potential to add credibility.
A below par Q2 and Q3 means the end of IOVA for current common shareholders as the thugs wouldโ€™ve succeeded in handing over the company for a liquidation fire sale for cheap.
Disclosure: I initiated a position at $1.75 and will sell half at $3. Will ride out the rest. Will add a bunch if it breaks $5 on solid lung cancer news and positive news from Amtagvi plus Keytruda trial as it would point to growing demand from the product while the company is learning to reduce COGS.
๐Ÿ‘๏ธ0
StormanNTM StormanNTM 2 weeks ago
IOVA BREAKOUT!!
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Structural_Biologist Structural_Biologist 3 weeks ago
This is a brilliant response thank you! Yes youโ€™re absolutely right itโ€™s involved and time consuming.
👍️ 1
badgerkid badgerkid 3 weeks ago
jondoeuk, thanks for jumping in. There's just no helping this guy understand that this is an Iovance board. He posts his pretty pictures and graphs, he pumps his company of choice - a company on the verge of financial failure, he insults posters who don't fully agree with his interpretation of the science, and he simply has become a complete waste of time on this board. Some of his posts do get deleted for off-topic and for the equivalent of spam.

Any thoughts on how to educate someone who is so hell bent of causing confusion and spreading misinformation?

Thanks again for your info. Always appreciated.

Good luck to IOVA longs.
👍️ 3 💯 1
dstock07734 dstock07734 3 weeks ago
See what CYT107 can do?

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jondoeuk jondoeuk 3 weeks ago
The poster (click on it to reduce the compression)

👍️ 2
dstock07734 dstock07734 3 weeks ago
Can you show a figure like the following? You have to have a significant number of Tscm cells.

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jondoeuk jondoeuk 3 weeks ago
TIL therapy cannot stimulate Tscm cells vital for immune memory.

From one IOVA presentation: ''Our novel TIL expansion process improves multiple metrics that correlate with both TIL persistence and response, including enhanced polyfunctionality, reduced inhibitory receptor expression and a less differentiated and more stem-like phenotype, while increasing yield.'' https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.2542
👍️ 3
dstock07734 dstock07734 3 weeks ago
Can you show me a heatmap like the following from TIL therapy? If you can, I'll stop posting.

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dstock07734 dstock07734 3 weeks ago
Which part of my posts is misinformation? Let IOVA retailers have their own judgements. They can tell if something is BS. By deleting my posts, you deprive them of the opportunity.
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badgerkid badgerkid 3 weeks ago
I almost hate posting this, but due to continual misinformation and lack of understanding from a certain poster who continually pumps a failing company on this board (Northwest Bio), I share the following AI generated response for clarity (I did not vet all of the info in this brief summary):

"T-cell stem cell memory (TSCM) cells and tumor-infiltrating lymphocytes (TILs) play a crucial role in cancer immunotherapy, particularly in adoptive T-cell therapy. TSCM cells, with their self-renewal and long-term persistence, are valuable for long-lasting anti-tumor immunity, while TILs, which are T cells that have infiltrated a tumor, are a source of tumor-reactive T cells for therapy.
.
TSCM cells are a type of memory T cell with stem-like properties, meaning they can self-renew and generate new T cells. They are characterized by their ability to persist for long periods and maintain their ability to respond to antigens. In cancer immunotherapy, TSCM cells are being explored as a potential source of T cells with superior long-term persistence and anti-tumor efficacy.
.
TIL therapy involves isolating T cells from the tumor microenvironment (TILs), expanding them in the lab, and then reinfusing them into the patient to target cancer cells. TILs are a valuable source of tumor-reactive T cells, as they have already been exposed to the tumor and have developed a specific anti-tumor response.
Relationship between TSCM and TILs:
.
TSCM cells can be present within the tumor and contribute to the pool of TILs. Furthermore, TILs can differentiate into memory T cell subsets, including TSCM, over time. Understanding the relationship between TSCM and TILs is important for designing effective adoptive T-cell therapies, as it may be possible to leverage TSCM cells to enhance the persistence and efficacy of TIL therapy.
Potential Benefits of TSCM in TIL Therapy:
.
By incorporating TSCM cells into TIL therapy, it is possible to enhance the long-term persistence and anti-tumor activity of the infused T cells. This could lead to a more durable anti-tumor response and potentially a higher rate of complete remission.
.
While TSCM and TILs hold promise for cancer immunotherapy, there are challenges to overcome. These include ensuring the T cells persist and do not become exhausted, as well as optimizing the conditions for expansion and reinfusion. Future research will focus on better understanding the factors that influence the differentiation and function of TSCM cells and TILs, as well as developing strategies to enhance their persistence and efficacy in adoptive T-cell therapies."

The future of cancer treatment will be the continual refinements of multiple approaches and optimizing any and all combinations that match best with specific cancer types. It's not one or the other, it's all at the same time and perfecting the match of meds and/or therapies at the best moment in the progression of the disease.

Pumping companies that are on the verge of financial failure like Northwest Bio, even if their science has hope, does not belong on the Iovance board. I don't know why this remains a difficult concept for certain individuals.

GL IOVA longs.
👍️ 2
dstock07734 dstock07734 3 weeks ago
TIL therapy cannot stimulate Tscm cells vital for immune memory. It is not the incompetence of IOVA management that led the landslide of the sp. The true reason is the complete change of the landscape in cancer treatment. If Joseph Edelman is exiting, it doesn't bode well.
๐Ÿ‘๏ธ0
jondoeuk jondoeuk 3 weeks ago
It is time consuming and labour intensive, consisting of whole-exome sequencing of DNA, RNA sequencing, creating tandem minigenes, requiring patient-specific monocyte-derived dendritic cells, and selecting the TIL to co-culture with the dendritic cells, before expansion of the neoantigen-reactive TIL. The time from resection to treatment was up to six months, often requiring bridging therapy.

There were a number of correlations with response, including fewer prior lines of therapy, number of neoantigen-reactive CD4+ TIL infused, and the number of neoantigens targeted by the TIL.

A much simpler and quicker method for Iovance would be enriching and expanding PD-1hiCD39+ and/or PD-1+ICOS+ CD4+ T-cells, and building off of that https://insight.jci.org/articles/view/142513 https://www.jci.org/articles/view/156821
👍️ 1
badgerkid badgerkid 3 weeks ago
Dstock is consistant at bringing little value to this board. Again, resectable vs unresectable, do you honestly not understand what you're posting?

This is all old news, it's always been part of the Iovance story, and regardless the success of these other approaches, Iovance will never have a shortage of patients to treat.

Spend a little more time understanding the science, the differences, the addressable market, and then go post all of that info somewhere else because your constant attempt to mislead on this board has grown tiresome.

You are a time bandit for anyone reading your posts.

GL to IOVA longs.
👍️ 1
dstock07734 dstock07734 3 weeks ago
Another neoadjuvant checking point inhibitor treatment can reduce the number of lung cancer patients who otherwise come to IOVA for the 2nd line treatment.

Neoadjuvant Osimertinib for Resectable EGFR-Mutated Non-Small-Cell Lung Cancer
https://ascopubs.org/doi/pdf/10.1200/JCO-25-00883

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badgerkid badgerkid 3 weeks ago
Dstock, once again you're confused about the future of cancer treatment. It's a much bigger market that will continually be refined, where treatments will be far better matched to the specifics of each cancer, and where combination therapies will continue to become more commonplace, not less.

I'm glad to hear that you'll never be responding to me again - I feel free like I've never felt before.
👍️ 1 😆 1
dstock07734 dstock07734 3 weeks ago
This is just one type of neoadjuvant PD1 inhibitor treatment. More will come.

I didn't respond to you first. You replied to my post first.

Here I only talk about neoadjuvant PD1 inhibitor. Once DCVax-L has the approval, IOVA is going to have a hard time for its survival.

Exit this one while you can. This would be my last post to you.
๐Ÿ‘๏ธ0
badgerkid badgerkid 3 weeks ago
How many patients could potentially benefit from TIL therapy? Does Iovance have the means to support all of them?

There is no shortage of patients for TIL therapy. Iovance has no concerns about all the patients that they won't see, they're focused on all of the patients that will need TIL therapy - which is far more than they will ever be able to handle (sadly).

You post like there's some magic pill out there that will some how eliminate the need for TIL therapy.

The person that doesn't get it is you. You continue to imply that Iovance is somehow going to suffer because some patients (thank goodness) will never need TIL therapy.

You state things that simply aren't true, your conclusions are ludicrous, and frankly, you're nothing more than an obsessive poster with little value offered to the discussion of Iovance and cancer treatment for that matter.

Try thinking before posting next time - and then don't post.

And you told me that you would never respond to me anymore - another post of yours that just wasn't true.
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dstock07734 dstock07734 3 weeks ago
You simply cannot get it, can you?

Amtagvi is the 2nd line treatment, is it not? Neoadjuvant PD1 inhibitor treatment will significantly reduce the number of patients who have to seek the 2nd line treatment. Can you get it now?
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badgerkid badgerkid 3 weeks ago
Dstock once again doesn't understand what's he's posting. He actually hurts the knowledge base of investors with his incessant nonsense.

"Three cycles of neoadjuvant nivolumab plus chemotherapy significantly improved overall survival among patients with resectable NSCLC as compared with chemotherapy alone."

A resectable cancer by definition can be fully removed by surgery. If successfully removed, the likelihood of positive results following prophylactic treatment or any type of preconditioning with neoadjuvant treatment should be very high. Even without any other type of treatment, if you surgically remove the entire tumor and there's been no spread, the survival results will still be very good. The treatments are done to add a layer of protection just in case.

But here's the problem. What if the tumor is spreading, metastatic, unresectable? When you can show those results on unresectable cancers or metastatic cancers with additional metastases, you'll have something.

That's what TIL therapy can do that all these other treatments cannot do. Iovance is delivering on TIL therapy, and it will continue to be seen as a preferred choice for many types of solid tumor cancers where potential or known spread has occurred, or the tumor is not resectable due to location.

Amtagvi and all future TIL therapies will continue to be the preferred choice for metastatic or unresectable solid tumors. For the record, that's a huge market that we can only hope to catch a small percentage of currently.

GL to IOVA longs.

As a layman, I offer this with the understanding that my explanations may not be perfectly stated, but if anyone who is more skilled in the science wishes to add to this conversation, I'd greatly appreciate it.
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dstock07734 dstock07734 3 weeks ago
Did I remind this board about the competition from neoadjuvant PD1 inhibitor in treating melanoma?

Now the new paper on treating lung cancer with neoadjuvant Opdivo in combination with chemo was published. Read it yourself. Amtagvi is going to have tough competition.

Overall Survival with Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer
https://www.nejm.org/doi/full/10.1056/NEJMoa2502931








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badgerkid badgerkid 3 weeks ago
"The Journal of Clinical Oncology Publishes Five-year Analysis of Amtagvi® (lifileucel) in Patients with Advanced Melanoma"

https://ir.iovance.com/news-releases/news-release-details/journal-clinical-oncology-publishes-five-year-analysis-amtagvir
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