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Cellectis SA

Cellectis SA (CLLS)

2.28
-0.06
(-2.56%)
At close: September 18 4:00PM
2.28
0.00
( 0.00% )
After Hours: 4:18PM

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Key stats and details

Current Price
2.28
Bid
2.15
Ask
2.42
Volume
20,173
2.23 Day's Range 2.40
0.962777 52 Week Range 3.7735
Market Cap
Previous Close
2.34
Open
2.35
Last Trade
1
@
2.3
Last Trade Time
16:00:07
Financial Volume
$ 47,067
VWAP
2.3332
Average Volume (3m)
45,653
Shares Outstanding
100,090,000
Dividend Yield
-
PE Ratio
-2.52
Earnings Per Share (EPS)
-1.01
Revenue
9.24M
Net Profit
-101.06M

About Cellectis SA

Cellectis SA is a biotechnology company focused on developing immunotherapies for cancer. The company engages in gene editing in an attempt to lead the body's immune system toward attacking cancer cells. Cellectis utilizes strategic corporate partnerships along with cooperation through various unive... Cellectis SA is a biotechnology company focused on developing immunotherapies for cancer. The company engages in gene editing in an attempt to lead the body's immune system toward attacking cancer cells. Cellectis utilizes strategic corporate partnerships along with cooperation through various university clinical centers. The company's gene-editing technologies allow for the creation of healthy cells derived from healthy donors rather than the patients themselves. It reports two segments: Therapeutics and Plants. Its Therapeutics segment focuses on novel cancer therapies, while its Plants segment focuses on agricultural biotechnology. Show more

Sector
Pharmaceutical Preparations
Industry
Pharmaceutical Preparations
Headquarters
Paris, Paris, Fra
Founded
-
Cellectis SA is listed in the Pharmaceutical Preparations sector of the NASDAQ with ticker CLLS. The last closing price for Cellectis was $2.34. Over the last year, Cellectis shares have traded in a share price range of $ 0.962777 to $ 3.7735.

Cellectis currently has 100,090,000 shares outstanding. The market capitalization of Cellectis is $234.21 million. Cellectis has a price to earnings ratio (PE ratio) of -2.52.

CLLS Latest News

Cellectis Presents Pre-Clinical Evidence of MUC1 CAR T-cells Reducing Triple-Negative Breast Cancer While Preserving Safety

NEW YORK, Sept. 03, 2024 (GLOBE NEWSWIRE) -- Cellectis (the โ€œCompanyโ€) (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform...

Cellectis Publishes a Molecular Therapy Article on a SMART DUAL CAR T-cell Approach for Treating Recalcitrant Solid Tumors

NEW YORK, Aug. 26, 2024 (GLOBE NEWSWIRE) -- Cellectis (the โ€œCompanyโ€) (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform...

Cellectis Appoints Dr. Adrian Kilcoyne as Chief Medical Officer

NEW YORK, Aug. 07, 2024 (GLOBE NEWSWIRE) -- Cellectis (the โ€œCompanyโ€) (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform...

Cellectis Provides Financial Resultsย for the Second Quarter 2024

ODD and RPDD granted by the FDA and ODD granted by the European Commission to UCART22 for the treatment of ALLODD granted by the FDA to CLLS52 (alemtuzumab) for ALL treatmentCash position of $273...

FDA Grants Orphan Drug Designation to Cellectisโ€™ CLLS52 (alemtuzumab)ย For ALL Treatment

NEW YORK, Aug. 01, 2024 (GLOBE NEWSWIRE) -- Cellectis (the โ€œCompanyโ€) (Euronext Growth: ALCLS - NASDAQ:ย  CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform...

PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
10.020.8849557522122.262.42.16188512.33267765CS
4-0.05-2.145922746782.332.4252.12230772.33591119CS
120.4222.58064516131.862.431.82456532.14500107CS
26-0.28-10.93752.563.381.82495832.46244322CS
520.5733.33333333331.713.77350.9627775177582.71190502CS
156-11.59-83.561643835613.8714.170.9627772696083.54705926CS
260-10.23-81.774580335712.5134.710.9627772506179.24724653CS

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CLLS Discussion

View Posts
Monksdream Monksdream 2 months ago
CLLS under $3
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tw0122 tw0122 2 months ago
FDA Grants Orphan Drug and Rare Pediatric Disease Designation Status to Cellectisโ€™ UCART22 product candidate for Acute Lymphoblastic Leukemia (ALL) Treatment

Source: GlobeNewswire Inc.

Cellectis (the โ€œCompanyโ€) (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug (ODD) and Rare Pediatric Disease Designation (RPDD) Status to UCART22 product candidate for the treatment of Acute Lymphoblastic Leukemia (ALL).
ALL represents about 10% of all leukemia cases in the United States, progresses rapidly, and is typically fatal within weeks or months if left untreated. It is estimated that 6,660 new cases of ALL and 1,560 deaths related to the disease occurred in the US in 20222.

Mark Frattini, M.D., Ph.D., Chief Medical Officer at Cellectis said: โ€œWe are excited that the FDA granted UCART22 both ODD and RPDD Status in the treatment of acute lymphoblastic leukemia. This decision represents additional evidence of the potential of UCART22 to bring a much-needed therapeutic option to these patients with ALL. There is an urgent need to develop new therapies for ALL for patients who are not candidates for HSCT or relapse after CD19 directed CAR T-cell therapies and/or HSCT.โ€

UCART22 is an allogeneic CAR T-cell product candidate targeting CD22 and evaluated in BALLI-01, a Phase 1/2 open-label dose-escalation and dose-expansion study, designed to evaluate the safety, expansion, persistence and clinical activity of UCART22 in patients with relapse/refractory ALL.

The last clinical data presented by Cellectis at the American Society of Hematology in December 2023 were encouraging and suggested that UCART22-P2 (fully manufactured at Cellectis) is more potent with a preliminary response rate of 67% at Dose Level 2, compared to a 50% response rate at Dose Level 3 with UCART22-P1 (manufactured by an external CDMO). Cellectis expects to provide updates on the progress of BALLI-01 by year-end 2024.

The FDA grants ODD status to medicines intended for the treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the US, an RPDD is granted for serious or life-threatening disease in which the serious or life-threatening manifestations, such as mortality with relapsed and/or refractory disease, primarily affect individuals aged from birth to 18 years. Receiving ODD may help to expedite and reduce the cost of development, approval, and commercialization of a therapeutic agent. Receiving RPDD may lead to receiving a rare pediatric disease priority review voucher at the time of marketing approval.

About Cellectis?
Cellectis is a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies. Cellectis utilizes an allogeneic approach for CAR-T immunotherapies in oncology, pioneering the concept of off-the-shelf and ready-to-use gene-edited CAR T-cells to treat cancer patients, and a platform to make therapeutic gene editing in hemopoietic stem cells for various diseases. As a clinical-stage biopharmaceutical company with over 24 years of experience and expertise in gene editing, Cellectis is developing life-changing product candidates utilizing TALEN®, its gene editing technology, and PulseAgile, its pioneering electroporation system to harness the power of the immune system in order to treat diseases with unmet medical needs. Cellectisโ€™ headquarters are in Paris, France, with locations in New York, New York and Raleigh, North Carolina. Cellectis is listed on the Nasdaq Global Market (ticker: CLLS) and on Euronext Growth (ticker: ALCLS).?

Forward-looking Statements????
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Monksdream Monksdream 2 months ago
CLLS under $3
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Monksdream Monksdream 2 months ago
CLLS under $2
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PonkenPlonken PonkenPlonken 4 months ago
Look who wants to be a part of this... Many many partners and very real biobucks.
AZN increasing their stake like this - validates their science.
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Monksdream Monksdream 4 months ago
CLLS under $3
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Monksdream Monksdream 5 months ago
CLLS under $3
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Monksdream Monksdream 10 months ago
Cellectis (Euronext Growth: ALCLS โ€“ NASDAQ: CLLS) today anounced that, following the consultation of its works council, it has now signed a binding Subsequent Investment Agreement with AstraZeneca (LSE/STO/Nasdaq: AZN) regarding the contemplated additional equity investment of $140M by AstraZeneca, which was previously announced on November 1, 2023. The additional investment will be made by way of subscription of 10,000,000 โ€œclass Aโ€ convertible preferred shares and 18,000,000 โ€œclass Bโ€ convertible preferred shares, in each case at a price of $5.00 per share (the โ€œAdditional Investmentโ€).
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Money hunt Money hunt 11 months ago
Still on fire 🔥 Big deal in the works
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Money hunt Money hunt 11 months ago
Popping pills and buying shares and flying everywhere dudes !!!
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TheFinalCD TheFinalCD 11 months ago
2.99 on sale
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TheFinalCD TheFinalCD 11 months ago
i did just buy 2k @ 2.48 then it had a nice pop

more green is good
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TheFinalCD TheFinalCD 11 months ago
yeah they had me cough my shares back up, for a small profit

they=algos


first off they gapped it up way too high in the 1st place, so its hard to go in with size when the previous close was .97

they do this BS all the time to retail

when news hits you have no chance of buying in low, they rail it up so fast, before you even get done reading the news

then they short it back until it finds support or they decide to change directions

as a day trader Im so sick of this routine
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Jess070283 Jess070283 11 months ago
Next stop $4+ IMOโ€ฆ
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MetaMonster MetaMonster 11 months ago
Not with FDA green light
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zj3001 zj3001 11 months ago
The $80m upfront for 22% equity suggest the market cap should be about $363m + other assets.
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jchords jchords 11 months ago
Think itโ€™ll be a while?
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MetaMonster MetaMonster 11 months ago
Huge news CLLS Rnaz is next
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Monksdream Monksdream 11 months ago
Long day ahead
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TheFinalCD TheFinalCD 11 months ago
NICE NEWS

https://www.globenewswire.com/news-release/2023/11/01/2770788/0/en/Cellectis-Announces-Strategic-Collaboration-and-Investment-Agreements-with-AstraZeneca.html

https://dilutiontracker.com/app/search/CLLS
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Monksdream Monksdream 11 months ago
Will it grow legs after 9:30
Will it trend north for days, weeks, months
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tw0122 tw0122 11 months ago
straZeneca to Invest $245 Million in Deal With Cellectis

Source: Dow Jones News
By Ben Otto


British drugmaker AstraZeneca plans to invest $245 million in a deal with biotechnology company Cellectis to develop next-generation therapeutics in oncology, immunology and rare diseases.

AstraZeneca said Wednesday that it will initially make a $105 million payment to Paris-based Cellectis in the fourth quarter, comprising an $80 million equity investment, for a 22% stake in the company, and $25 million in cash.

AstraZeneca plans to make a further $140 million equity investment, subject to regulatory and other approvals, with a closing in early 2024, taking its total stake in Cellectis to 44%.

AstraZeneca said it plans to leverage Cellectis's gene-editing technologies and manufacturing capabilities to design novel cell and gene therapy products.

Cellectis will be eligible to receive an investigational new drug option fee and various milestone payments ranging from $70 million to up to $220 million for each of 10 candidate products, plus tiered royalties, AstraZeneca said.

AstraZeneca will retain an option for an exclusive license for the products developed under the research collaboration agreement.

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Monksdream Monksdream 12 months ago
CLLS under $2
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Monksdream Monksdream 1 year ago
Cellectis SA NASDAQ: CLLS

GoSymbol lookup
Health Care : Biotechnology | Small Cap Value | Based in FranceCompany profile
Cellectis SA is a France-based company active in the field of genome engineering and genomic surgery. The Company specializes in the research, development, and commercialization of rational genome engineering technologies. The Company develops immunotherapies that aim to force the immune system to target and eradicate cancer cells. It has developed an expertise in combining meganucleases with engineered targeting Deoxyribonucleic Acid (DNA) matrices into Meganuclease Recombination Systems (MRS), used for gene excision, correction or replacement. Cellectis SA markets its technologies mainly for use in the research field, in pharmaceutical drug discovery programs, in the agronomics, bioproduction, and biotherapeutics fields. Cellectis SA operates several subsidiaries. The Company operates in France and the United States, among others.
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Frankestin Frankestin 1 year ago
https://www.cellectis.com/uploads/files/051123_PosterASGCT2023_BAOa.pdf
https://www.cellectis.com/uploads/files/UCART123_AMELI-01_Phase_1_Oral_Presentation_ASGCT_2023_Final_Upload.pdf
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Frankestin Frankestin 1 year ago
file:///C:/Users/bozh/Downloads/UCART123_AMELI-01_Phase_1_Oral_Presentation_ASGCT_2023_Final_Upload.pdf
file:///C:/Users/bozh/Downloads/051123_PosterASGCT2023_BAOa.pdf

Evidence of UCART123 anti-tumor activity was observed in four patients out of fifteen at DL2 or above with best overall responses in the FCA arm. Two out of eight patients (25%) at DL2 in the FCA arm achieved meaningful response: * A patient who failed five prior lines of therapy experienced a durable minimal residual disease (MRD) negative complete response (CR) with full count recovery at Day 56 that continues beyond one year.

* A patient with stable disease achieved greater than 90% bone marrow blast reduction (60% to 5%) at Day 28.

The preliminary data show that adding alemtuzumab to the FC LD regimen was associated with sustained lymphodepletion and significantly higher UCART123 cell expansion, which correlated with improved anti-tumor activity.

Patient Enrollment in a 2-Dose Regimen Arm

Overall, these preliminary data support the continued administration of UCART123 after FCA lymphodepletion in patients with r/r AML. Based on observed UCART123 expansion patterns and cytokine profiles, pursuant to an amended protocol, a second dose of UCART123 is given after 10-14 days to allow for additional UCART123 expansion and clinical activity without the use of additional lymphodepletion. The UCART123 cell expansion from the second dose of UCART123, in the setting of reduced disease burden, is expected to be safe and allow for clearance of residual disease.

โ€œThese clinically meaningful preliminary data from the AMELI-01 study are very encouraging for patients and for the future of allogeneic CART-cell therapy. AML is a disease with an urgent need for alternative treatment options for patients, and we are excited to be moving the study forward,โ€ said Dr. Mark Frattini, M.D., Ph.D., Chief Medical Officer at Cellectis. โ€œWe have now implemented a two-dose regimen arm for our AMELI-01 trial and we look forward to sharing future updates as they become available.โ€
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Frankestin Frankestin 1 year ago
grabbed a handful yesterday.
I wonder if tomorrow they surprise us a little?
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Frankestin Frankestin 2 years ago
https://ih.advfn.com/stock-market/NASDAQ/cellectis-CLLS/stock-news/83912184/cellectis-announces-withdrawal-of-follow-on-offeri
Seems like it's better now...
I hope they sell them to pfizer
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Frankestin Frankestin 2 years ago
Cellectis Announces Positive Preliminary Clinical Data for UCART22 in ALL and UCART123 in AML

* UCART22: ANTI-TUMOR ACTIVITY OBSERVED IN 60% (N=3) OF PATIENTS AT DL3 USING FCA LYMPHODEPLETION
* AMELI-01 STUDY (EVALUATING UCART123) NOW ENROLLING PATIENTS IN A TWO-DOSE REGIMEN ARM AT DL2
* UCART123: 25% (N=2) OF PATIENTS AT DL2 IN FCA ARM ACHIEVED MEANINGFUL RESPONSE
* NEXT DATA SET IS EXPECTED TO BE RELEASED IN 2023
* UCART123: ONE PATIENT EXPERIENCED A DURABLE MINIMAL RESIDUAL DISEASE (MRD)-NEGATIVE COMPLETE RESPONSE THAT CONTINUES BEYOND 12 MONTHS


dry hands still sell
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Frankestin Frankestin 2 years ago
will there be something interesting?

November 4(th), 2022, at 8:00 AM EDT / 2:00 PM CET. The call will include the Companyโ€™s third quarter results and an update on business activities.

he is quite slapped in the face and someone sees him for $ 2

in a while they will have to load money somehow ...
apparently they refused to bid when she was high
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Frankestin Frankestin 2 years ago
also interesting here!
Yes, yes
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whytestocks whytestocks 5 years ago
News: $CLLS Cellectis and Lonza Enter cGMP Manufacturing Service Agreement for Cellectis' Allogeneic UCART Product Candidates

Agreement covers manufacturing of clinical supply for Cellectis’ UCART pipeline Manufacturing to take place at Lonza’s GMP site in Geleen, Netherlands Regulatory News: Cellectis (Paris:ALCLS) (NASDAQ:CLLS) (Euronext Growth: ALCLS – Nasdaq: CLLS), a cl...

Read the whole news CLLS - Cellectis and Lonza Enter cGMP Manufacturing Service Agreement for Cellectis' Allogeneic UCART Product Candidates
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n4807g n4807g 7 years ago
J.P Morgan Healthcare conference presentation is worth listening to. At current valuation CLLS is undervalued.....very undervalued.
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n4807g n4807g 7 years ago
Not uncommon with new therapies. Much too early to draw any conclusions about UCART123. The trial will most likely resume with recommended adjustments.
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Avispa Avispa 7 years ago
https://seekingalpha.com/news/3293436-cellectis-29-percent-premarket-fda-hold-studies-ucart123-fatality
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north40000 north40000 7 years ago
FDA imposes clinical hold on CART-123.... patient death.
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n4807g n4807g 7 years ago
with the GILD acquisition of KITE the potential for CAR-T, and more specifically Alogeneic CAR-T increases dramatically. FWIW CLLS is one of the leaders (if not the leader) in this sphere. Additionally, their partnership with Pfizer opens tantalizing possibilities for the future if the technology, and their therapies prove valid.

Something worth reading:

http://www.pfizer.com/news/press-release/press-release-detail/pfizer_and_cellectis_enter_into_global_strategic_cancer_immunotherapy_collaboration

and of particular interest.....

Under the terms of the agreement, Pfizer has exclusive rights to pursue development and commercialization of CAR-T therapies, in the field of oncology, directed at a total of fifteen targets selected by Pfizer. Both companies will work together on preclinical research and Pfizer will be responsible for the development and potential commercialization of any CAR-T therapies for the Pfizer-selected targets. In addition, the agreement provides for a total of twelve targets selected by Cellectis. Both companies will work together on preclinical research on four Cellectis-selected targets and Cellectis will work independently on eight additional targets. Cellectis will be responsible for clinical development and commercialization of CAR-T therapeutics for the Cellectis-selected targets. Pfizer has right of first refusal to the four Cellectis-selected targets.

I am long CLLS and accumulating shares.
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u508 u508 8 years ago
Cellectisโ€™CAR-T cells act as โ€œuniversal donorโ€ cells.

Other CAR-T therapies must remove immune system cells from a patientโ€™s blood. Then these cells have to be worked on in a lab. They must be multiplied. Genes must be edited. Then the cells have to be reinfused into the patient to do their work.

Each patient is a one-off therapeutic product! Each dose will cost tens of thousands of dollars just to make.

Cellectis, however, has created a line of CAR-T cells that can work in anyone.
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Sixman Sixman 8 years ago
I read that too. The CART Space is interesting and I understand CLLS is developing a method that would allow more treatment of multiple types of cancer?

It's showing good signs of strength.
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u508 u508 8 years ago
interest due to successful treatment of little girl using their "universal" CAR-T cells. Wish I had cash to buy more shares but I'm a small investor - $20+ is expensive for me....
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Sixman Sixman 8 years ago
Lots of interest last few days. Anyone out there following CLLS?
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lucmariepierre lucmariepierre 8 years ago
Sincerely i have no idea
It was 45 dollars
Now it is 20 dollars

This stock is unbalanced i think

Why so high or so low ?
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murocman murocman 8 years ago
Anyone have any idea on when the first results from the Ph I trial at UCL might be published. All I can find is the the trial is open label and is non-comparative---no information on number of patients or time to completion.

GLTA,

Murocman
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biscotte biscotte 8 years ago
CNBC : CLLS ==> 100$ ! ???



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north40000 north40000 8 years ago
http://in.reuters.com/article/us-health-celltherapy-idINKCN0XX1F7?feedType=RSS&feedName=health&utm_source=Twitter&utm_medium=Social&utm_campaign=Feed%3A+reuters%2FINhealth+%28News+%2F+IN+%2F+Health%29

"A second baby with aggressive leukaemia has been treated in London with "designer immune cells" developed by Cellectis and, six months after treatment, remains in remission, the French biotech firm said.

Cellectis shares jumped 14 percent following Friday's news.

The first human use of the company's cell therapy made headlines worldwide in November when one-year-old Layla was cleared of previously incurable leukaemia at Britain's Great Ormond Street Hospital (GOSH).

Details of the latest compassionate care case, also treated at GOSH, were presented at the American Society of Gene & Cell Therapy annual meeting in Washington.

The so-called UCART19 injection works by adding new genes to healthy donated immune cells known as T-cells, which arm them against leukaemia.[more]
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venturecapp venturecapp 9 years ago
Post-Holiday Action: Movers and Shakers in Biotech - article mentions Cellectis

http://marketexclusive.com/post-holiday-action-movers-and-shakers-in-biotech/1207/
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MrPoppaGeorgeo MrPoppaGeorgeo 9 years ago
Et like da (I) not da (o)(o)
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~Angel~ ~Angel~ 9 years ago
vroom
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MrPoppaGeorgeo MrPoppaGeorgeo 9 years ago
CLLS has the V power (I)
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MrPoppaGeorgeo MrPoppaGeorgeo 9 years ago
Boooom CLLS was just at $24
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