Safety and Immunological data from both
cohorts of the recently completed Phase 1/2 trial will be presented
on May 5th
PLYMOUTH
MEETING, Pa., April 27,
2023 /PRNewswire/ -- INOVIO (NASDAQ: INO), a
biotechnology company focused on developing and commercializing DNA
medicines to help treat and protect people from HPV-associated
diseases, cancer, and infectious diseases, today announced that an
abstract has been accepted for oral presentation on INO-3107 for
the treatment of Recurrent Respiratory Papillomatosis (RRP) at this
year's American Broncho-Esophagological Association (ABEA) program
at the Combined Otolaryngology Spring Meetings (COSM) in
Boston, Massachusetts.
"We are pleased that lead investigator Dr. Ted Mau will have the opportunity to share
additional encouraging insights on the safety and immunogenicity of
INO-3107 from both cohorts of our recently completed study," said
Dr. Mike Sumner, INOVIO's Chief
Medical Officer.
Details of the ABEA at COSM presentation are as follows:
Title: Phase 1/2 Open-label, Multicenter Trial Of
INO-3107 With Electroporation In Adult Patients With HPV-6 And/or
HPV-11-associated Recurrent Respiratory Papillomatosis: Interim
Analysis
Session: ABEA Scientific Session III: Voice
Session Date and Time: Friday, May 5, 2023,
9:00 am EDT
Location: 304/306 (Hynes)
The presentation will include new safety, immunological, and
demographic data from both cohorts of a Phase 1/2 trial evaluating
the safety, tolerability, immunogenicity, and efficacy of INO-3107
in 32 patients with HPV-6 and/or HPV-11-associated RRP.
About RRP
RRP is a debilitating and rare disease caused primarily by HPV-6
and/or HPV-11. RRP is characterized by the development of small,
wart-like growths, or papillomas, in the respiratory tract. While
papillomas are generally benign, they can cause severe,
life-threatening airway obstruction and respiratory complications.
RRP can also significantly affect quality of life for patients by
affecting the voice box, limiting the ability to speak effectively.
Surgery to remove papillomas is the standard of care for RRP;
however, the papillomas often grow back because the underlying HPV
infection has not been eradicated.
The most widely cited U.S. epidemiology data from 1995 cites
14,000 active cases and about 1.8 per 100,000 new cases in adults
each year. More recent pediatric epidemiology data cites a range of
0.5 - 0.7 per 100,000 new cases in children in the US each
year.
About INO-3107
INO-3107 is INOVIO's clinical-stage DNA medicine product
candidate being developed as a potential treatment for RRP.
INO-3107 is designed to elicit a targeted T cell response against
HPV-6 and HPV-11, the HPV types responsible for causing RRP among
other HPV-related diseases. These targeted T cells are designed to
seek out and kill infected cells, with the aim of potentially
preventing or slowing the growth of new papillomas.
INO-3107 received Orphan Drug Designation from the U.S.
Food and Drug Administration (FDA) in July
2020. For more information about our HPV franchise, please
visit https://ir.inovio.com/events-and-presentations/default.aspx
About INOVIO
INOVIO is a biotechnology company focused on developing and
commercializing DNA medicines to help treat and protect people from
HPV-associated diseases, cancer, and infectious diseases. INOVIO's
DNA medicines in development are delivered using its
investigational proprietary smart device, CELLECTRA®, to
produce immune responses against targeted pathogens and cancers.
For more information, visit www.inovio.com.
Contacts
Media: Jennie
Willson (267) 429-8567 jennie.willson@inovio.com
Investors: Thomas Hong (267)
440-4298 thomas.hong@inovio.com
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SOURCE INOVIO Pharmaceuticals, Inc.